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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39574

FusionGeneSummary for TRIO_ADAMTS12

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO_ADAMTS12
Fusion gene ID: 39574
HgeneTgene
Gene symbol

TRIO

ADAMTS12

Gene ID

7204

81792

Gene nametrio Rho guanine nucleotide exchange factorADAM metallopeptidase with thrombospondin type 1 motif 12
SynonymsARHGEF23|MEBAS|MRD44|tgatPRO4389
Cytomap

5p15.2

5p13.3-p13.2

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
Modification date2018052720180519
UniProtAcc

O75962

P58397

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000509967, ENST00000515710, 
ENST00000344135, 		ENST00000504830, 
ENST00000352040, ENST00000504582, 
ENST00000515401, 
Fusion gene scores* DoF score26 X 18 X 10=46807 X 4 X 5=140
# samples 277
** MAII scorelog2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND ADAMTS12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

TgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

TgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

TgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

TgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

TgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

TgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

TgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

TgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A44Q-06ATRIOchr5

14381361

+ADAMTS12chr5

33881585

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000344204ENST00000504830TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
Frame-shiftENST00000344204ENST00000352040TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000344204ENST00000504582TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000344204ENST00000515401TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
Frame-shiftENST00000537187ENST00000504830TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
Frame-shiftENST00000537187ENST00000352040TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000537187ENST00000504582TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000537187ENST00000515401TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
Frame-shiftENST00000509967ENST00000504830TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
Frame-shiftENST00000509967ENST00000352040TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000509967ENST00000504582TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
5CDS-intronENST00000509967ENST00000515401TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-3CDSENST00000515710ENST00000504830TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-3CDSENST00000515710ENST00000352040TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-intronENST00000515710ENST00000504582TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-intronENST00000515710ENST00000515401TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-3CDSENST00000344135ENST00000504830TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-3CDSENST00000344135ENST00000352040TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-intronENST00000344135ENST00000504582TRIOchr5

14381361

+ADAMTS12chr5

33881585

-
intron-intronENST00000344135ENST00000515401TRIOchr5

14381361

+ADAMTS12chr5

33881585

-

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FusionProtFeatures for TRIO_ADAMTS12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

O75962

ADAMTS12

P58397

Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}. Metalloprotease that may play a role in the degradationof COMP. Cleaves also alpha-2 macroglobulin and aggregan. Hasanti-tumorigenic properties. {ECO:0000269|PubMed:16611630,ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIO_ADAMTS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIO_ADAMTS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIOFLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25ADAMTS12CALM2, MEOX2, MYL6, UBR1, FKBP9, SP3, PPM1A, SNRK, USF2, USF1, RUFY3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIO_ADAMTS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIO_ADAMTS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIOC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneTRIOC0023903Liver neoplasms1CTD_human
HgeneTRIOC0032927Precancerous Conditions1CTD_human
TgeneADAMTS12C0036341Schizophrenia1PSYGENET