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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39567

FusionGeneSummary for TRIM9_DNAJA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM9_DNAJA2
Fusion gene ID: 39567
HgeneTgene
Gene symbol

TRIM9

DNAJA2

Gene ID

114088

10294

Gene nametripartite motif containing 9DnaJ heat shock protein family (Hsp40) member A2
SynonymsRNF91|SPRINGCPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2
Cytomap

14q22.1

16q11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM9RING finger protein 91RING-type E3 ubiquitin transferase TRIM9homolog of rat RING finger Springtripartite motif-containing protein 9dnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14
Modification date2018052220180523
UniProtAcc

Q9C026

O60884

Ensembl transtripts involved in fusion geneENST00000298355, ENST00000338969, 
ENST00000360392, ENST00000557456, 
ENST00000317089, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM9 [Title/Abstract] AND DNAJA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM9

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20085810

TgeneDNAJA2

GO:0042026

protein refolding

21231916


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ340966TRIM9chr14

51443336

+DNAJA2chr16

46990804

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000298355ENST00000317089TRIM9chr14

51443336

+DNAJA2chr16

46990804

+
intron-3UTRENST00000338969ENST00000317089TRIM9chr14

51443336

+DNAJA2chr16

46990804

+
intron-3UTRENST00000360392ENST00000317089TRIM9chr14

51443336

+DNAJA2chr16

46990804

+
intron-3UTRENST00000557456ENST00000317089TRIM9chr14

51443336

+DNAJA2chr16

46990804

+

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FusionProtFeatures for TRIM9_DNAJA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM9

Q9C026

DNAJA2

O60884

E3 ubiquitin-protein ligase which ubiquitinates itselfin cooperation with an E2 enzyme UBE2D2/UBC4 and serves as atargeting signal for proteasomal degradation. May play a role inregulation of neuronal functions and may also participate in theformation or breakdown of abnormal inclusions in neurodegenerativedisorders. May act as a regulator of synaptic vesicle exocytosisby controlling the availability of SNAP25 for the SNARE complexformation. {ECO:0000269|PubMed:20085810}. Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM9_DNAJA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM9_DNAJA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM9_DNAJA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM9_DNAJA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource