FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3955

FusionGeneSummary for BCAS3_KAT7

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAS3_KAT7
Fusion gene ID: 3955
HgeneTgene
Gene symbol

BCAS3

KAT7

Gene ID

54828

11143

Gene nameBCAS3, microtubule associated cell migration factorlysine acetyltransferase 7
SynonymsGAOB1|MAABHBO1|HBOA|MYST2|ZC2HC7
Cytomap

17q23.2

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1histone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1
Modification date2018052320180523
UniProtAcc

Q9H6U6

O95251

Ensembl transtripts involved in fusion geneENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
ENST00000259021, ENST00000454930, 
ENST00000509773, ENST00000510819, 
ENST00000424009, ENST00000503935, 
ENST00000435742, ENST00000513980, 
Fusion gene scores* DoF score40 X 23 X 15=138003 X 2 X 2=12
# samples 473
** MAII scorelog2(47/13800*10)=-4.87586369998789
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCAS3 [Title/Abstract] AND KAT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

HgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

HgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058

TgeneKAT7

GO:0006260

DNA replication

16387653

TgeneKAT7

GO:0031098

stress-activated protein kinase signaling cascade

21856198

TgeneKAT7

GO:0043966

histone H3 acetylation

16387653

TgeneKAT7

GO:0043981

histone H4-K5 acetylation

16387653

TgeneKAT7

GO:0043982

histone H4-K8 acetylation

16387653

TgeneKAT7

GO:0043983

histone H4-K12 acetylation

16387653

TgeneKAT7

GO:0043984

histone H4-K16 acetylation

16387653

TgeneKAT7

GO:1900182

positive regulation of protein localization to nucleus

24739512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A250-01ABCAS3chr17

59161925

+KAT7chr17

47893165

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000589222ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000589222ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000589222ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000407086ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000407086ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000390652ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000390652ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000408905ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000408905ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588462ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000588462ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000585744ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000585744ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
Frame-shitENST00000588874ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
5CDS-3UTRENST00000588874ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000259021BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000454930BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000509773BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000510819BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000424009BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000503935BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3CDSENST00000585812ENST00000435742BCAS3chr17

59161925

+KAT7chr17

47893165

+
intron-3UTRENST00000585812ENST00000513980BCAS3chr17

59161925

+KAT7chr17

47893165

+

Top

FusionProtFeatures for BCAS3_KAT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAS3

Q9H6U6

KAT7

O95251

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity towardhistone H3 and is responsible for the bulk of histone H4acetylation in vivo. Involved in H3K14 (histone H3 lysine 14)acetylation and cell proliferation (By similarity). Throughchromatin acetylation it may regulate DNA replication and act as acoactivator of TP53-dependent transcription. Acts as a coactivatorof the licensing factor CDT1 (PubMed:18832067). Specificallyrepresses AR-mediated transcription.{ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470,ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932,ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18832067}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BCAS3_KAT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BCAS3_KAT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2BKAT7VIM, CEP70, ZNF165, HOOK2, DVL3, CALCOCO2, NINL, KCTD13, ZBTB8A, AR, ORC1, KATNBL1, PACSIN1, CAAP1, SEPT5, PPID, RGL2, RPS10, WDR33, CBX8, DDX11, ATN1, POLB, SAT1, SNAPIN, ING4, ING5, JADE1, JADE2, JADE3, MEAF6, TP53, HIST1H4A, CDT1, JUN, GMNN, CDC6, ORC2, MCM2, CDK11B, HIST1H3A, HIST2H2AC, CSNK1E, DYNC1I1, HAP1, BARD1, LRIF1, APP, EZH2, RNF2, IFI16, HIST1H2BG, XPO1, DAXX, S100A4, TMPO, ING3, DDB2, POU5F1, BRPF3, BRD1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BCAS3_KAT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BCAS3_KAT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource