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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39531

FusionGeneSummary for TRIM37_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM37_FAU
Fusion gene ID: 39531
HgeneTgene
Gene symbol

TRIM37

FAU

Gene ID

4591

2197

Gene nametripartite motif containing 37FAU, ubiquitin like and ribosomal protein S30 fusion
SynonymsMUL|POB1|TEF3FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

17q22

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism proteinubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052220180522
UniProtAcc

O94972

P62861

Ensembl transtripts involved in fusion geneENST00000393066, ENST00000262294, 
ENST00000376149, ENST00000393065, 
ENST00000584889, 
ENST00000529639, 
ENST00000531743, ENST00000525297, 
ENST00000527548, ENST00000279259, 
ENST00000529259, ENST00000434372, 
Fusion gene scores* DoF score8 X 7 X 6=3367 X 6 X 2=84
# samples 87
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM37 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM37

GO:0000122

negative regulation of transcription by RNA polymerase II

25470042

HgeneTRIM37

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

HgeneTRIM37

GO:0035518

histone H2A monoubiquitination

25470042

HgeneTRIM37

GO:0036353

histone H2A-K119 monoubiquitination

25470042

HgeneTRIM37

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

HgeneTRIM37

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300

HgeneTRIM37

GO:0051865

protein autoubiquitination

15885686

HgeneTRIM37

GO:0070842

aggresome assembly

15885686


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU566095TRIM37chr17

57189470

-FAUchr11

64888260

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393066ENST00000529639TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393066ENST00000531743TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393066ENST00000525297TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393066ENST00000527548TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393066ENST00000279259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3UTRENST00000393066ENST00000529259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-intronENST00000393066ENST00000434372TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000262294ENST00000529639TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000262294ENST00000531743TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000262294ENST00000525297TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000262294ENST00000527548TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000262294ENST00000279259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3UTRENST00000262294ENST00000529259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-intronENST00000262294ENST00000434372TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000376149ENST00000529639TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000376149ENST00000531743TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000376149ENST00000525297TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000376149ENST00000527548TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000376149ENST00000279259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3UTRENST00000376149ENST00000529259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-intronENST00000376149ENST00000434372TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393065ENST00000529639TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393065ENST00000531743TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393065ENST00000525297TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393065ENST00000527548TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000393065ENST00000279259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3UTRENST00000393065ENST00000529259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-intronENST00000393065ENST00000434372TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000584889ENST00000529639TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000584889ENST00000531743TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000584889ENST00000525297TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000584889ENST00000527548TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3CDSENST00000584889ENST00000279259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-3UTRENST00000584889ENST00000529259TRIM37chr17

57189470

-FAUchr11

64888260

-
intron-intronENST00000584889ENST00000434372TRIM37chr17

57189470

-FAUchr11

64888260

-

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FusionProtFeatures for TRIM37_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM37

O94972

FAU

P62861


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIM37_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM37_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM37_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM37_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM37C0524582Mulibrey Nanism4CTD_human;ORPHANET;UNIPROT
HgeneTRIM37C0016063Osteitis Fibrosa Disseminata1CTD_human
HgeneTRIM37C0019209Hepatomegaly1CTD_human;HPO
HgeneTRIM37C0376634Craniofacial Abnormalities1CTD_human