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Fusion gene ID: 39489

FusionGeneSummary for TRIM27_MDM2

Fusion gene summary

Fusion gene information	Fusion gene name: TRIM27_MDM2
	Fusion gene ID: 39489
		Hgene	Tgene
	Gene symbol	TRIM27	MDM2
	Gene ID	5987	4193
	Gene name	tripartite motif containing 27	MDM2 proto-oncogene
	Synonyms	RFP\|RNF76	ACTFS\|HDMX\|hdm2
	Cytomap	6p22.1	12q15
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
	Modification date	20180522	20180527
	UniProtAcc	P14373	Q00987
	Ensembl transtripts involved in fusion gene	ENST00000377194, ENST00000377199, ENST00000498117, ENST00000459807, ENST00000412687, ENST00000437160, ENST00000427689, ENST00000435528, ENST00000485666, ENST00000468364, ENST00000455861, ENST00000417660, ENST00000400720, ENST00000495323, ENST00000491158, ENST00000437415, ENST00000468047, ENST00000431123, ENST00000452265,	ENST00000462284, ENST00000356290, ENST00000540827, ENST00000258149, ENST00000428863, ENST00000393412, ENST00000258148, ENST00000544561, ENST00000393410, ENST00000393413, ENST00000517852, ENST00000545204, ENST00000350057, ENST00000360430, ENST00000299252, ENST00000348801, ENST00000478070, ENST00000544125,
Fusion gene scores	* DoF score	3 X 4 X 3=36	10 X 7 X 6=420
	# samples	4	9
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/420*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRIM27 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRIM27	GO:0000122	negative regulation of transcription by RNA polymerase II	10976108
Hgene	TRIM27	GO:0006469	negative regulation of protein kinase activity	22128329
Hgene	TRIM27	GO:0032897	negative regulation of viral transcription	18248090
Hgene	TRIM27	GO:0034314	Arp2/3 complex-mediated actin nucleation	23452853
Hgene	TRIM27	GO:0042147	retrograde transport, endosome to Golgi	23452853
Hgene	TRIM27	GO:0045087	innate immune response	18248090
Hgene	TRIM27	GO:0045814	negative regulation of gene expression, epigenetic	10976108
Hgene	TRIM27	GO:0051091	positive regulation of DNA binding transcription factor activity	23077300
Hgene	TRIM27	GO:0070206	protein trimerization	17156811
Tgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Tgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Tgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Tgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Tgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Tgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Tgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Tgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Tgene	MDM2	GO:0045184	establishment of protein localization	10360174
Tgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Tgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Tgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Tgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Tgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Tgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BX485283	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000377194	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377194	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377194	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377194	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377194	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377194	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377199	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377199	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377199	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377199	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000377199	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000377199	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000498117	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000498117	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000498117	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000498117	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000498117	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000498117	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000459807	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000459807	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000459807	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000459807	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000459807	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000459807	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000412687	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000412687	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000412687	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000412687	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000412687	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000412687	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437160	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437160	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437160	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437160	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437160	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437160	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000427689	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000427689	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000427689	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000427689	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000427689	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000427689	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000435528	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000435528	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000435528	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000435528	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000435528	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000435528	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000485666	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000485666	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000485666	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000485666	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000485666	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000485666	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468364	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468364	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468364	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468364	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468364	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468364	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000455861	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000455861	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000455861	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000455861	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000455861	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000455861	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000417660	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000417660	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000417660	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000417660	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000417660	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000417660	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000400720	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000400720	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000400720	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000400720	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000400720	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000400720	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000495323	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000495323	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000495323	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000495323	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000495323	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000495323	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000491158	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000491158	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000491158	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000491158	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000491158	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000491158	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437415	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437415	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437415	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437415	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000437415	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000437415	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468047	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468047	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468047	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468047	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000468047	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000468047	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000431123	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000431123	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000431123	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000431123	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000431123	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000431123	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000452265	ENST00000462284	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000452265	ENST00000356290	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000452265	ENST00000540827	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000452265	ENST00000258149	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-3UTR	ENST00000452265	ENST00000428863	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000393412	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000258148	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000544561	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000393410	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000393413	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000517852	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000545204	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000350057	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000360430	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000299252	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000348801	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000478070	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+
intron-intron	ENST00000452265	ENST00000544125	TRIM27	chr6	214414	-	MDM2	chr12	69234138	+

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FusionProtFeatures for TRIM27_MDM2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TRIM27 P14373	MDM2 Q00987
E3 ubiquitin-protein ligase that mediates ubiquitinationof PIK3C2B and inhibits its activity; mediates the formation of'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport:together with MAGEL2, mediates the formation of 'Lys-63'-linkedpolyubiquitin chains at 'Lys-220' of WASHC1, leading to promoteendosomal F-actin assembly (PubMed:23452853). Has atranscriptional repressor activity by cooperating with EPC1.Induces apoptosis by activating Jun N-terminal kinase and p38kinase and also increases caspase-3-like activity independently ofmitochondrial events. May function in male germ cell development.Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269\|PubMed:10976108,ECO:0000269\|PubMed:12807881, ECO:0000269\|PubMed:22128329,ECO:0000269\|PubMed:23452853}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TRIM27_MDM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM27_MDM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TRIM27_MDM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	MDM2	Q00987	DB01593	Zinc	E3 ubiquitin-protein ligase Mdm2	small molecule	approved\|investigational

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RelatedDiseases for TRIM27_MDM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	MDM2	C0007131	Non-Small Cell Lung Carcinoma	2	CTD_human
Tgene	MDM2	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	MDM2	C0019693	HIV Infections	1	CTD_human
Tgene	MDM2	C0021364	Male infertility	1	CTD_human
Tgene	MDM2	C0025202	melanoma	1	CTD_human
Tgene	MDM2	C0032927	Precancerous Conditions	1	CTD_human
Tgene	MDM2	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	MDM2	C1458155	Mammary Neoplasms	1	CTD_human

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Fusion gene ID: 39489

FusionGeneSummary for TRIM27_MDM2

FusionProtFeatures for TRIM27_MDM2

FusionGeneSequence for TRIM27_MDM2

FusionGenePPI for TRIM27_MDM2

RelatedDrugs for TRIM27_MDM2

RelatedDiseases for TRIM27_MDM2