FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39476

FusionGeneSummary for TRIM24_SVOPL

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM24_SVOPL
Fusion gene ID: 39476
HgeneTgene
Gene symbol

TRIM24

SVOPL

Gene ID

8805

136306

Gene nametripartite motif containing 24SVOP like
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1-
Cytomap

7q33-q34

7q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1putative transporter SVOPLSV2 related protein homolog-like
Modification date2018051920180522
UniProtAcc

O15164

Q8N434

Ensembl transtripts involved in fusion geneENST00000343526, ENST00000415680, 
ENST00000497516, 
ENST00000288513, 
ENST00000436657, ENST00000421622, 
ENST00000463557, ENST00000419765, 
Fusion gene scores* DoF score6 X 6 X 5=1801 X 1 X 1=1
# samples 71
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: TRIM24 [Title/Abstract] AND SVOPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A1HM-01ATRIM24chr7

138258387

+SVOPLchr7

138281275

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000343526ENST00000288513TRIM24chr7

138258387

+SVOPLchr7

138281275

-
Frame-shiftENST00000343526ENST00000436657TRIM24chr7

138258387

+SVOPLchr7

138281275

-
Frame-shiftENST00000343526ENST00000421622TRIM24chr7

138258387

+SVOPLchr7

138281275

-
5CDS-5UTRENST00000343526ENST00000463557TRIM24chr7

138258387

+SVOPLchr7

138281275

-
5CDS-5UTRENST00000343526ENST00000419765TRIM24chr7

138258387

+SVOPLchr7

138281275

-
Frame-shiftENST00000415680ENST00000288513TRIM24chr7

138258387

+SVOPLchr7

138281275

-
Frame-shiftENST00000415680ENST00000436657TRIM24chr7

138258387

+SVOPLchr7

138281275

-
Frame-shiftENST00000415680ENST00000421622TRIM24chr7

138258387

+SVOPLchr7

138281275

-
5CDS-5UTRENST00000415680ENST00000463557TRIM24chr7

138258387

+SVOPLchr7

138281275

-
5CDS-5UTRENST00000415680ENST00000419765TRIM24chr7

138258387

+SVOPLchr7

138281275

-
intron-3CDSENST00000497516ENST00000288513TRIM24chr7

138258387

+SVOPLchr7

138281275

-
intron-3CDSENST00000497516ENST00000436657TRIM24chr7

138258387

+SVOPLchr7

138281275

-
intron-3CDSENST00000497516ENST00000421622TRIM24chr7

138258387

+SVOPLchr7

138281275

-
intron-5UTRENST00000497516ENST00000463557TRIM24chr7

138258387

+SVOPLchr7

138281275

-
intron-5UTRENST00000497516ENST00000419765TRIM24chr7

138258387

+SVOPLchr7

138281275

-

Top

FusionProtFeatures for TRIM24_SVOPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM24

O15164

SVOPL

Q8N434

Transcriptional coactivator that interacts with numerousnuclear receptors and coactivators and modulates the transcriptionof target genes. Interacts with chromatin depending on histone H3modifications, having the highest affinity for histone H3 that isboth unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotesubiquitination and proteasomal degradation of p53/TP53. Plays arole in the regulation of cell proliferation and apoptosis, atleast in part via its effects on p53/TP53 levels. Up-regulatesligand-dependent transcription activation by AR, GCR/NR3C1,thyroid hormone receptor (TR) and ESR1. Modulates transcriptionactivation by retinoic acid (RA) receptors, including RARA. Playsa role in regulating retinoic acid-dependent proliferation ofhepatocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538,ECO:0000269|PubMed:21164480}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TRIM24_SVOPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TRIM24_SVOPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM24ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1BSVOPLIQCB1, UBE2S


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRIM24_SVOPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TRIM24_SVOPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTRIM24C2239176Liver carcinoma1CTD_human