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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3947

FusionGeneSummary for BCAS3_CYTH1

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAS3_CYTH1
Fusion gene ID: 3947
HgeneTgene
Gene symbol

BCAS3

CYTH1

Gene ID

54828

9267

Gene nameBCAS3, microtubule associated cell migration factorcytohesin 1
SynonymsGAOB1|MAABB2-1|CYTOHESIN-1|D17S811E|PSCD1|SEC7
Cytomap

17q23.2

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1cytohesin-1PH, SEC7 and coiled-coil domain-containing protein 1SEC7 homolog B2-1cytoadhesin 1homolog of secretory protein SEC7pleckstrin homology, Sec7 and coiled-coil domains 1
Modification date2018052320180519
UniProtAcc

Q9H6U6

Q15438

Ensembl transtripts involved in fusion geneENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
ENST00000585509, ENST00000589297, 
ENST00000591455, ENST00000446868, 
ENST00000361101, ENST00000589296, 
ENST00000586175, 
Fusion gene scores* DoF score40 X 23 X 15=138005 X 5 X 2=50
# samples 477
** MAII scorelog2(47/13800*10)=-4.87586369998789
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCAS3 [Title/Abstract] AND CYTH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

HgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

HgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058

TgeneCYTH1

GO:0030155

regulation of cell adhesion

12606567


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A0TQ-01ABCAS3chr17

59001861

+CYTH1chr17

76705814

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000589222ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000589222ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000589222ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000589222ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000589222ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000589222ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000589222ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000407086ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000407086ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000390652ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000390652ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000408905ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000408905ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588462ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000588462ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000585744ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000585744ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-5UTRENST00000588874ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
5CDS-intronENST00000588874ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000585509BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000589297BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000591455BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000446868BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000361101BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-5UTRENST00000585812ENST00000589296BCAS3chr17

59001861

+CYTH1chr17

76705814

-
intron-intronENST00000585812ENST00000586175BCAS3chr17

59001861

+CYTH1chr17

76705814

-

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FusionProtFeatures for BCAS3_CYTH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAS3

Q9H6U6

CYTH1

Q15438

Promotes guanine-nucleotide exchange on ARF1, ARF5 andARF6. Promotes the activation of ARF factors through replacementof GDP with GTP. Plays an important role in membrane trafficking,during junctional remodeling and epithelial polarization, throughregulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11,ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262,ECO:0000269|PubMed:9653114}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCAS3_CYTH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCAS3_CYTH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2BCYTH1ARFRP1, IPCEF1, ITGB2, CYTIP, TRIM23, ITSN1, GNAQ, ARRB2, ARF6, ARRB1, UBA5, CNKSR1, CCDC120, C1orf106, CCDC40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BCAS3_CYTH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCAS3_CYTH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource