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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39464

FusionGeneSummary for TRIM14_CORO2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM14_CORO2A
Fusion gene ID: 39464
HgeneTgene
Gene symbol

TRIM14

CORO2A

Gene ID

9830

7464

Gene nametripartite motif containing 14coronin 2A
Synonyms-CLIPINB|IR10|WDR2
Cytomap

9q22.33

9q22.33

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 14tripartite motif protein TRIM14coronin-2AWD protein IR10WD repeat-containing protein 2WD-repeat protein 2coronin, actin binding protein, 2Acoronin-like protein B
Modification date2018052720180519
UniProtAcc

Q14142

Q92828

Ensembl transtripts involved in fusion geneENST00000375098, ENST00000478530, 
ENST00000342043, ENST00000341469, 
ENST00000538344, 
ENST00000343933, 
ENST00000375077, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 3=48
# samples 44
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM14 [Title/Abstract] AND CORO2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM14

GO:0032897

negative regulation of viral transcription

18248090

HgeneTRIM14

GO:0045087

innate immune response

18248090

HgeneTRIM14

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

HgeneTRIM14

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A8NI-01ATRIM14chr9

100881264

-CORO2Achr9

100899970

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375098ENST00000343933TRIM14chr9

100881264

-CORO2Achr9

100899970

-
In-frameENST00000375098ENST00000375077TRIM14chr9

100881264

-CORO2Achr9

100899970

-
intron-3CDSENST00000478530ENST00000343933TRIM14chr9

100881264

-CORO2Achr9

100899970

-
intron-3CDSENST00000478530ENST00000375077TRIM14chr9

100881264

-CORO2Achr9

100899970

-
In-frameENST00000342043ENST00000343933TRIM14chr9

100881264

-CORO2Achr9

100899970

-
In-frameENST00000342043ENST00000375077TRIM14chr9

100881264

-CORO2Achr9

100899970

-
In-frameENST00000341469ENST00000343933TRIM14chr9

100881264

-CORO2Achr9

100899970

-
In-frameENST00000341469ENST00000375077TRIM14chr9

100881264

-CORO2Achr9

100899970

-
intron-3CDSENST00000538344ENST00000343933TRIM14chr9

100881264

-CORO2Achr9

100899970

-
intron-3CDSENST00000538344ENST00000375077TRIM14chr9

100881264

-CORO2Achr9

100899970

-

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FusionProtFeatures for TRIM14_CORO2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM14

Q14142

CORO2A

Q92828


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM14chr9:100881264chr9:100899970ENST00000341469-1619_6169443Zinc fingerB box-type
HgeneTRIM14chr9:100881264chr9:100899970ENST00000342043-1719_6169564Zinc fingerB box-type
HgeneTRIM14chr9:100881264chr9:100899970ENST00000375098-1719_6169660Zinc fingerB box-type
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112485_52467526Coiled coilOntology_term=ECO:0000255
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112485_52467526Coiled coilOntology_term=ECO:0000255
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112123_17067526RepeatNote=WD 3
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112171_21467526RepeatNote=WD 4
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112215_25967526RepeatNote=WD 5
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112260_30567526RepeatNote=WD 6
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-112306_34267526RepeatNote=WD 7
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-11272_12267526RepeatNote=WD 2
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112123_17067526RepeatNote=WD 3
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112171_21467526RepeatNote=WD 4
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112215_25967526RepeatNote=WD 5
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112260_30567526RepeatNote=WD 6
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-112306_34267526RepeatNote=WD 7
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-11272_12267526RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM14chr9:100881264chr9:100899970ENST00000341469-16135_15669443Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000341469-1676_10969443Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000342043-17135_15669564Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000342043-1776_10969564Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000375098-17135_15669660Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000375098-1776_10969660Coiled coilOntology_term=ECO:0000255
HgeneTRIM14chr9:100881264chr9:100899970ENST00000341469-16249_44269443DomainB30.2/SPRY
HgeneTRIM14chr9:100881264chr9:100899970ENST00000342043-17249_44269564DomainB30.2/SPRY
HgeneTRIM14chr9:100881264chr9:100899970ENST00000375098-17249_44269660DomainB30.2/SPRY
TgeneCORO2Achr9:100881264chr9:100899970ENST00000343933-11224_7167526RepeatNote=WD 1
TgeneCORO2Achr9:100881264chr9:100899970ENST00000375077-11224_7167526RepeatNote=WD 1


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FusionGeneSequence for TRIM14_CORO2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIM14_CORO2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIM14RNF2, NCK1, SAMD1, MAVS, TRAF3, IKBKG, TBK1, RNF125CORO2ANCOR1, NR1H2, UBE2I, THAP4, CORO1A, TMEM52B, CAPZA2, DBN1, FLNA, MYH9, MYO1C, IQGAP1, SYNPO, LIMA1, ANLN, SDHAF2, MYO19, MYO18A, CORO2B, RGS3, CSN2, SLC5A8, FERD3L, BCLAF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIM14_CORO2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM14_CORO2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource