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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39448

FusionGeneSummary for TREX2_NRXN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TREX2_NRXN1
Fusion gene ID: 39448
HgeneTgene
Gene symbol

TREX2

NRXN1

Gene ID

11219

9378

Gene namethree prime repair exonuclease 2neurexin 1
Synonyms-Hs.22998|PTHSL2|SCZD17
Cytomap

Xq28

2p16.3

Type of geneprotein-codingprotein-coding
Descriptionthree prime repair exonuclease 23'-5' exonuclease TREX2 long formneurexin-1neurexin I
Modification date2018052320180519
UniProtAcc

Q9BQ50

Q9ULB1

Ensembl transtripts involved in fusion geneENST00000370231, ENST00000393862, 
ENST00000402951, ENST00000414588, 
ENST00000334497, ENST00000370232, 
ENST00000330912, ENST00000338525, 
ENST00000342183, ENST00000401710, 
ENST00000404971, ENST00000406316, 
ENST00000405472, ENST00000401669, 
ENST00000406859, ENST00000402717, 
ENST00000331040, ENST00000405581, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 4=144
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TREX2 [Title/Abstract] AND NRXN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTREX2

GO:0006259

DNA metabolic process

11279105


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X99270TREX2chrX

152713126

-NRXN1chr2

51083187

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370231ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370231ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000393862ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000402951ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000414588ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000334497ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000370232ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000330912ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000342183TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000401710TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000404971TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000406316TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000405472TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000401669TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000406859TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000402717TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000331040TREX2chrX

152713126

-NRXN1chr2

51083187

+
intron-intronENST00000338525ENST00000405581TREX2chrX

152713126

-NRXN1chr2

51083187

+

Top

FusionProtFeatures for TREX2_NRXN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TREX2

Q9BQ50

NRXN1

Q9ULB1

Exonuclease with a preference for double-stranded DNAwith mismatched 3' termini. May play a role in DNA repair.{ECO:0000269|PubMed:11279105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TREX2_NRXN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TREX2_NRXN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TREX2_NRXN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNRXN1Q9ULB1DB11093Calcium CitrateNeurexin-1small moleculeapproved
TgeneNRXN1Q9ULB1DB11348Calcium PhosphateNeurexin-1small moleculeapproved

Top

RelatedDiseases for TREX2_NRXN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRXN1C0004352Autistic Disorder4CTD_human
TgeneNRXN1C0036341Schizophrenia3CTD_human
TgeneNRXN1C0005586Bipolar Disorder2PSYGENET
TgeneNRXN1C0011570Mental Depression1PSYGENET
TgeneNRXN1C0011581Depressive disorder1PSYGENET
TgeneNRXN1C0023014Language Development Disorders1CTD_human
TgeneNRXN1C0376634Craniofacial Abnormalities1CTD_human
TgeneNRXN1C1510586Autism Spectrum Disorders1CTD_human
TgeneNRXN1C1970431PITT-HOPKINS SYNDROME1CTD_human
TgeneNRXN1C3714756Intellectual Disability1CTD_human