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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39416

FusionGeneSummary for TRAPPC9_PLEKHA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAPPC9_PLEKHA2
Fusion gene ID: 39416
HgeneTgene
Gene symbol

TRAPPC9

PLEKHA2

Gene ID

83696

59339

Gene nametrafficking protein particle complex 9pleckstrin homology domain containing A2
SynonymsIBP|IKBKBBP|MRT13|NIBP|T1|TRS120TAPP2
Cytomap

8q24.3

8p11.22

Type of geneprotein-codingprotein-coding
Descriptiontrafficking protein particle complex subunit 9IKK2 binding proteinNIK and IKK-beta binding proteinNIK- and IKBKB-binding proteinTRAPP 120 kDa subunittularik gene 1 proteinpleckstrin homology domain-containing family A member 2PH domain-containing family A member 2TAPP-2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2tandem PH Domain containing protein-2tandem PH domain-conta
Modification date2018052320180523
UniProtAcc

Q96Q05

Q9HB19

Ensembl transtripts involved in fusion geneENST00000389327, ENST00000389328, 
ENST00000438773, ENST00000522504, 
ENST00000521746, ENST00000420274, 
ENST00000388745, 
Fusion gene scores* DoF score16 X 11 X 9=15847 X 7 X 3=147
# samples 177
** MAII scorelog2(17/1584*10)=-3.21996568394191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAPPC9 [Title/Abstract] AND PLEKHA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A3MO-06ATRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000389327ENST00000521746TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
Frame-shiftENST00000389327ENST00000420274TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
5CDS-3UTRENST00000389327ENST00000388745TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
Frame-shiftENST00000389328ENST00000521746TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
Frame-shiftENST00000389328ENST00000420274TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
5CDS-3UTRENST00000389328ENST00000388745TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
Frame-shiftENST00000438773ENST00000521746TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
Frame-shiftENST00000438773ENST00000420274TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
5CDS-3UTRENST00000438773ENST00000388745TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
intron-3CDSENST00000522504ENST00000521746TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
intron-3CDSENST00000522504ENST00000420274TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+
intron-3UTRENST00000522504ENST00000388745TRAPPC9chr8

141034034

-PLEKHA2chr8

38793512

+

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FusionProtFeatures for TRAPPC9_PLEKHA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAPPC9

Q96Q05

PLEKHA2

Q9HB19

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. Mayrecruit other proteins to the plasma membrane (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAPPC9_PLEKHA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAPPC9_PLEKHA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAPPC9IKBKB, TRAPPC2, TRAPPC2L, TRAPPC3L, TRAPPC4, TRAPPC8, TRAPPC10, TRAPPC12, NOTCH1, AMOTL2, MOV10, NXF1, ODF3L2, SULT1A2, CNN2, BCL2L14, RUFY4, CABS1, ACAA1, CRYAB, NTRK1, APP, TRAPPC5, KANK4, TRAPPC1, STMN4, GATA2, GLB1, GRAMD1B, RAB30, BTBD1, KCTD3, LGALS3BP, TBC1D14, FAM19A3, CRTAC1, TRAPPC3, RAB3IP, TMEM102, MB21D2, PDLIM7, RAB3IL1PLEKHA2PLEKHA1, MPDZ, CDH1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAPPC9_PLEKHA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAPPC9_PLEKHA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource