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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39384

FusionGeneSummary for TRAPPC10_MDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAPPC10_MDS2
Fusion gene ID: 39384
HgeneTgene
Gene symbol

TRAPPC10

MDS2

Gene ID

7109

259283

Gene nametrafficking protein particle complex 10myelodysplastic syndrome 2 translocation associated
SynonymsEHOC-1|EHOC1|GT334|TMEM1|TRS130|TRS30-
Cytomap

21q22.3

1p36.11

Type of geneprotein-codingprotein-coding
Descriptiontrafficking protein particle complex subunit 10TRAPP 130 kDa subunitTRAPP subunit TMEM1epilepsy holoprosencephaly candidate-1 proteintrafficking protein particle complex subunit 130trafficking protein particle complex subunit TMEM1transmembrane protmyelodysplastic syndrome 2 translocation-associated protein
Modification date2018052320180425
UniProtAcc

P48553

Q8NDY4

Ensembl transtripts involved in fusion geneENST00000291574, ENST00000380221, 
ENST00000483973, 
ENST00000477916, 
ENST00000374555, 
Fusion gene scores* DoF score11 X 8 X 9=7922 X 2 X 2=8
# samples 142
** MAII scorelog2(14/792*10)=-2.50007360313464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TRAPPC10 [Title/Abstract] AND MDS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRAPPC10

GO:0051259

protein complex oligomerization

21525244


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CQ-A4CH-01ATRAPPC10chr21

45432441

+MDS2chr1

23966170

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000291574ENST00000477916TRAPPC10chr21

45432441

+MDS2chr1

23966170

+
5CDS-3UTRENST00000291574ENST00000374555TRAPPC10chr21

45432441

+MDS2chr1

23966170

+
5CDS-3UTRENST00000380221ENST00000477916TRAPPC10chr21

45432441

+MDS2chr1

23966170

+
5CDS-3UTRENST00000380221ENST00000374555TRAPPC10chr21

45432441

+MDS2chr1

23966170

+
intron-3UTRENST00000483973ENST00000477916TRAPPC10chr21

45432441

+MDS2chr1

23966170

+
intron-3UTRENST00000483973ENST00000374555TRAPPC10chr21

45432441

+MDS2chr1

23966170

+

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FusionProtFeatures for TRAPPC10_MDS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAPPC10

P48553

MDS2

Q8NDY4

May play a role in vesicular transport from endoplasmicreticulum to Golgi.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAPPC10_MDS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAPPC10_MDS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAPPC10TRAPPC2, TRAPPC2L, TRAPPC8, TRAPPC1, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC6A, TRAPPC6B, TRAPPC9, TRAPPC12, TRAPPC10, RDX, NOTCH1, AMOTL2, GPD2, BCL2L14, CABS1, DMTN, STMN4, KANK4, GLB1, GATA2, GRAMD1B, RAB30, BTBD1, CRTAC1, ZADH2, LGALS3BP, TBC1D14, CCDC102B, TRAPPC3, RAB3IP, TMEM102, MB21D2, PDLIM7, RAB3IL1, TRIM25MDS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAPPC10_MDS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAPPC10_MDS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRAPPC10C0037274Dermatologic disorders1CTD_human
HgeneTRAPPC10C0311375Arsenic Poisoning1CTD_human