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Fusion gene ID: 39372 |
FusionGeneSummary for TRAM1_CLVS1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TRAM1_CLVS1 | Fusion gene ID: 39372 | Hgene | Tgene | Gene symbol | TRAM1 | CLVS1 | Gene ID | 23471 | 157807 |
Gene name | translocation associated membrane protein 1 | clavesin 1 | |
Synonyms | PNAS8|TRAM|TRAMP | C6orf212L|CRALBPL|RLBP1L1 | |
Cytomap | 8q13.3 | 8q12.2-q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | translocating chain-associated membrane protein 1translocating chain-associating membrane proteintranslocation-associating membrane protein 1 | clavesin-1clathrin vesicle-associated Sec14 protein 1retinaldehyde-binding protein 1-like 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15629 | Q8IUQ0 | |
Ensembl transtripts involved in fusion gene | ENST00000521425, ENST00000262213, ENST00000536748, ENST00000521049, | ENST00000519846, ENST00000518592, ENST00000325897, ENST00000518858, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 9 X 7 X 8=504 |
# samples | 3 | 9 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/504*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TRAM1 [Title/Abstract] AND CLVS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-C8-A138-01A | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000521425 | ENST00000519846 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-5UTR | ENST00000521425 | ENST00000518592 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-5UTR | ENST00000521425 | ENST00000325897 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-intron | ENST00000521425 | ENST00000518858 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
Frame-shift | ENST00000262213 | ENST00000519846 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-5UTR | ENST00000262213 | ENST00000518592 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-5UTR | ENST00000262213 | ENST00000325897 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-intron | ENST00000262213 | ENST00000518858 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
In-frame | ENST00000536748 | ENST00000519846 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-5UTR | ENST00000536748 | ENST00000518592 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-5UTR | ENST00000536748 | ENST00000325897 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5CDS-intron | ENST00000536748 | ENST00000518858 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-3CDS | ENST00000521049 | ENST00000519846 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-5UTR | ENST00000521049 | ENST00000518592 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-5UTR | ENST00000521049 | ENST00000325897 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
5UTR-intron | ENST00000521049 | ENST00000518858 | TRAM1 | chr8 | 71512254 | - | CLVS1 | chr8 | 62289164 | + |
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FusionProtFeatures for TRAM1_CLVS1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TRAM1 | CLVS1 |
Stimulatory or required for the translocation ofsecretory proteins across the ER membrane. | Required for normal morphology of late endosomes and/orlysosomes in neurons (By similarity). Binds phosphatidylinositol3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250,ECO:0000269|PubMed:19651769}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAM1_CLVS1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TRAM1_ENST00000536748_chr8_71512254_-_CLVS1_ENST00000519846_chr8_62289164_+_234aa MVFLLGLMFEITAKASIIFVTLQYNVTLPATGTPSQTSFVPSCCHWKSXSKIRSFRXMASFXLXTGVIFPSNKPPNXHLQSLNWPLKGCR TAFLPALEESTLSTSPGTFMPSTHSSSHFLKTRPGNGFSCMETIXTAFTSXYTLNFCPLNLEELFLLMTWELGPGRYSVPTTAMKMTILT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TRAM1_ENST00000536748_chr8_71512254_-_CLVS1_ENST00000519846_chr8_62289164_+_704nt ATGGTCTTCCTGCTGGGGCTCATGTTTGAGATAACGGCAAAAGCTTCTATCATTTTTGTTACTCTTCAGTACAATGTCACCCTCCCAGCA ACAGGAACTCCTTCACAGACATCCTTCGTGCCATCCTGCTGTCATTGGAAGTCCTAATCGAAGATCCGGAGCTTCAGATAAATGGCTTCA TTTTAATTATAGACTGGAGTAATTTTTCCTTCAAACAAGCCTCCAAACTGACACCTTCAATCCTTAAACTGGCCATTGAAGGGTTGCAGG ACAGCTTTCCTGCCCGCTTTGGAGGAGTCCACTTTGTCAACCAGCCCTGGTACATTCATGCCCTCTACACACTCATCAAGCCATTTCTTA AAGACAAGACCAGGAAACGGATTTTCCTGCATGGAAACAATTTAAACAGCCTTCACCAGCTAATACACCCTGAATTTTTGCCCTCTGAAT TTGGAGGAACTCTTCCTCCTTATGACATGGGAACTTGGGCCCGGACGTTACTCGGTCCCGACTACAGCGATGAAAATGACTATACTCACA CATCCTATAATGCAATGCACGTGAAGCATACGTCCTCGAATCTGGAGAGAGAATGCTCACCCAAGCTGATGAAAAGATCTCAGTCTGTGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TRAM1_ENST00000536748_chr8_71512254_-_CLVS1_ENST00000519846_chr8_62289164_+_2973nt CCCCCGGGCGGCCCGGCGGCTGCGTACTGGCTGTGGGATGGGAAGTGAAGCCCCAGCGAGCGGCTGCAGCGGGGCCGTGAGGAGCAGCCA GCGGGAGGCGGCGGCGAGTCGGTGAGCAGCTGGGAAGAGCAGAACCGGGGCGGAGCACCTGCAGAATCACGCGGACATCGTCTCCTGTGT GGCGATGGTCTTCCTGCTGGGGCTCATGTTTGAGATAACGGCAAAAGCTTCTATCATTTTTGTTACTCTTCAGTACAATGTCACCCTCCC AGCAACAGGAACTCCTTCACAGACATCCTTCGTGCCATCCTGCTGTCATTGGAAGTCCTAATCGAAGATCCGGAGCTTCAGATAAATGGC TTCATTTTAATTATAGACTGGAGTAATTTTTCCTTCAAACAAGCCTCCAAACTGACACCTTCAATCCTTAAACTGGCCATTGAAGGGTTG CAGGACAGCTTTCCTGCCCGCTTTGGAGGAGTCCACTTTGTCAACCAGCCCTGGTACATTCATGCCCTCTACACACTCATCAAGCCATTT CTTAAAGACAAGACCAGGAAACGGATTTTCCTGCATGGAAACAATTTAAACAGCCTTCACCAGCTAATACACCCTGAATTTTTGCCCTCT GAATTTGGAGGAACTCTTCCTCCTTATGACATGGGAACTTGGGCCCGGACGTTACTCGGTCCCGACTACAGCGATGAAAATGACTATACT CACACATCCTATAATGCAATGCACGTGAAGCATACGTCCTCGAATCTGGAGAGAGAATGCTCACCCAAGCTGATGAAAAGATCTCAGTCT GTGGTAGAAGCTGGGACCCTGAAACATGAGGAGAAGGGAGAGAATGAGAACACCCAGCCACTCCTGGCTCTGGACTGAACCCTGAGTCAC CCCAATGCTCCTGCACACTGGCCTTCAGTGGTATCAGCCACCCAGGAAGCACATGCACAACTGACCCATGCAGACACGTGTGTTCTGCTT GACACAAGGTCCTCCACTCCTGAACCCCTGCAGTGACTGTCACCAGCCATCGGTCTGAGCAGCCAAAGTTGGACAAAGACTTGAGAGATG CTTTTTTTTTCCCCCAGTGAGGGGACTGGAGGATGATGCAAGGCATTTATGTAAAAAAGATTCTCCCTCCTTTCATATTTATTGTAGTAA ATTGAAAAAATAAAGACTAAATTTGATGGACACACTGCATTAGGACAAGAATTTTTCTGAGGTATCACACAGGGACCCTCTCCAGTTTTT GAAAATTAAGTGCATTTCCAAGTAAATGTATCAGAGTTAAACTGTACAGACACCACTGTCAAGTTTCATGTAGTACAAAGCCCTGAGACA ATAGTATCTCCAGTAATTTCCATTCTTACTGAATTATTTCCTTTGACCTCATCACCAGCATCGAATTGTTCAGCCTAAGAGCATGTTCTC ATAGGTCTGGGTATTTGCAAAGTTTGCTTATTTTGATGATATCCTGCAAAAAATTATTTTGATGTCACATCTCTTGTCAGGTCACTAGCT GACTGTCATGAGCTGACGTTAAAGGAAGACACATGGACGTGAAATACGATTATTTCATCTGAGCAATGTGAGTTACCACAGGCAGCTCAA AAGCCCATTAGTGCAGCATGTGTCTGCAGAGGAGATGTCTCATGAAAATCACATGTCAGTGATTAATGAATCCATTCCAGTTGCCTCAAC TGGGTCACTACAGCAAAGAAAAGTGCTATCAAACCATTTACCCTTGCCCCCACAACCCTCCTGCAACCATTAAAGATGTGGAGAAAGACC ATGGTTGTTGCTGAGAGGGTAAATATTCAATCATGGAGCATGACCCATATGGATGGCTAAATATGCAAGTACTGAAGTAAGAGAAGACTA GAAATGCAGGATGAAATGTCAAAGGTCATTTTATTTACCTAGTCTCCTTAGAAATGGAGTCCCCAACTACTCATTCAAAAGAAATCAGAC ATAAAATAAACAGACATCATATATGATATCCTTACTTGTGCCATGTTTTCCAAGACCAGTGCATATTTTTAGACATCTCTTATTCGCCCA GCCATCTGCATGACATGGGTATTTATTAGTATTACCAGTTGGTGCTCAAAGTCAAACAAAAATATTTTAGTTAATAATGGGCAGTAAAAT ATGATTTTACATTATTTTAAATATTTGGGAGAGTTAATTTGTTAGCTAAATAATTCAAGGGAAAGAGATTATTCAACTGGTCATAATCAC CCCTGATAATATTATTACTAATCTTAATTATTTATTACATCATCTCTTTCTCAATGGATCTAATGTTTTAATTTTTTCCCCTATTGGTAG AGAACAATAACAGAAGTAATTTTTATATTATACACTTGGAGAAATAAAGTTGAAACAGAATTAAAAATATTTCTCAAACAACTGTATCAC AATATAAATTAAACTAATTCATTTTTGTGTAGACATACGAAATCACAAAAATAATAACACTGAAATAATTCTACCAATGCAGTGATGGAA ACACTTTTCTTATGTACCAAGACATAGATAGGTAAGAGAAATAAAGAATTGAAGTGAATTAGAAAATCCATTTTATTGCTTGGGTTTAAA ATAGTTGTGGGATACAAGTATTTACAATGCTATTGGAGTCAATTATTGACAACACTTTGCAACAGTAATACCATTTCTAGCTTTTCAATT GGCAATACTTAGAACCTTACTGTAGTGACCTGATTTTAAATACCATATTATATTTACTAAGTTAAGAGCTAGTTTTTACTCTCTTCCATA ATTTCATTACATGAATGTAAGATGATGGCTCAAAAATGACGACTTATAGTTTGAATTTATGTGTATGCAATATACATATGAGAACCAAAT TCAACAAGTGACATGAATGTTACTACATGAACATTGAATTGTATTGCCCTTGTCAGTTATTTCCTCTGTTCAATAAATACTGAAGGTCAC |
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FusionGenePPI for TRAM1_CLVS1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TRAM1 | ESR1, ESR2, ELAVL1, DERL1, HM13, HLA-A, BCAP31, APP, VKORC1, TCTN3, CREB3, PKN2, MBOAT1, FAF2, TPTE, UBC | CLVS1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAM1_CLVS1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAM1_CLVS1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |