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Fusion gene ID: 39351 |
FusionGeneSummary for TRAF7_EIF4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRAF7_EIF4A1 | Fusion gene ID: 39351 | Hgene | Tgene | Gene symbol | TRAF7 | EIF4A1 | Gene ID | 84231 | 1973 |
| Gene name | TNF receptor associated factor 7 | eukaryotic translation initiation factor 4A1 | |
| Synonyms | RFWD1|RNF119 | DDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I | |
| Cytomap | 16p13.3 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRAF7RING finger and WD repeat-containing protein 1RING finger protein 119RING-type E3 ubiquitin transferase TRAF7TNF receptor-associated factor 7, E3 ubiquitin protein ligasering finger and WD repeat domain 1 | eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q6Q0C0 | P60842 | |
| Ensembl transtripts involved in fusion gene | ENST00000326181, | ENST00000380512, ENST00000293831, ENST00000577269, ENST00000582746, ENST00000581808, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 7 X 7 X 2=98 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TRAF7 [Title/Abstract] AND EIF4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRAF7 | GO:0000185 | activation of MAPKKK activity | 14743216 |
| Hgene | TRAF7 | GO:0006915 | apoptotic process | 15001576 |
| Hgene | TRAF7 | GO:0016567 | protein ubiquitination | 14743216 |
| Hgene | TRAF7 | GO:0043410 | positive regulation of MAPK cascade | 15001576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB119692 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000326181 | ENST00000380512 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
| 3UTR-3UTR | ENST00000326181 | ENST00000293831 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
| 3UTR-intron | ENST00000326181 | ENST00000577269 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
| 3UTR-3UTR | ENST00000326181 | ENST00000582746 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
| 3UTR-intron | ENST00000326181 | ENST00000581808 | TRAF7 | chr16 | 2227838 | - | EIF4A1 | chr17 | 7482008 | + |
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FusionProtFeatures for TRAF7_EIF4A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRAF7 | EIF4A1 |
| E3 ubiquitin ligase capable of auto-ubiquitination,following phosphorylation by MAP3K3. Potentiates MEKK3-mediatedactivation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptionalregulators. Induces apoptosis when overexpressed.{ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576}. | ATP-dependent RNA helicase which is a subunit of theeIF4F complex involved in cap recognition and is required for mRNAbinding to ribosome. In the current model of translationinitiation, eIF4A unwinds RNA secondary structures in the 5'-UTRof mRNAs which is necessary to allow efficient binding of thesmall ribosomal subunit, and subsequent scanning for the initiatorcodon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAF7_EIF4A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAF7_EIF4A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAF7_EIF4A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAF7_EIF4A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRAF7 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | EIF4A1 | C0019693 | HIV Infections | 1 | CTD_human |
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