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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39346

FusionGeneSummary for TRAF4_FASN

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF4_FASN
Fusion gene ID: 39346
HgeneTgene
Gene symbol

TRAF4

FASN

Gene ID

9618

2194

Gene nameTNF receptor associated factor 4fatty acid synthase
SynonymsCART1|MLN62|RNF83FAS|OA-519|SDR27X1
Cytomap

17q11.2

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 4MLN 62RING finger protein 83TRAF4 variant 6cysteine-rich domain associated with RING and Traf domains protein 1cysteine-rich domain associated with ring and TRAF domainmalignant 62metastatic lymph node gene 62 proteifatty acid synthaseshort chain dehydrogenase/reductase family 27X, member 1
Modification date2018052220180522
UniProtAcc

Q9BUZ4

P49327

Ensembl transtripts involved in fusion geneENST00000262395, ENST00000444415, 
ENST00000262396, 
ENST00000306749, 
ENST00000579758, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 5=245
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF4 [Title/Abstract] AND FASN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRAF4

GO:0045860

positive regulation of protein kinase activity

16157600

HgeneTRAF4

GO:0046330

positive regulation of JNK cascade

16157600

HgeneTRAF4

GO:0090073

positive regulation of protein homodimerization activity

16157600


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-QH-A6CV-01ATRAF4chr17

27071273

+FASNchr17

80038798

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262395ENST00000306749TRAF4chr17

27071273

+FASNchr17

80038798

-
5CDS-intronENST00000262395ENST00000579758TRAF4chr17

27071273

+FASNchr17

80038798

-
Frame-shiftENST00000444415ENST00000306749TRAF4chr17

27071273

+FASNchr17

80038798

-
5CDS-intronENST00000444415ENST00000579758TRAF4chr17

27071273

+FASNchr17

80038798

-
Frame-shiftENST00000262396ENST00000306749TRAF4chr17

27071273

+FASNchr17

80038798

-
5CDS-intronENST00000262396ENST00000579758TRAF4chr17

27071273

+FASNchr17

80038798

-

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FusionProtFeatures for TRAF4_FASN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF4

Q9BUZ4

FASN

P49327

Adapter protein and signal transducer that links membersof the tumor necrosis factor receptor (TNFR) family to differentsignaling pathways. Plays a role in the activation of NF-kappa-Band JNK, and in the regulation of cell survival and apoptosis.Regulates activation of NF-kappa-B in response to signalingthrough Toll-like receptors. Required for normal skeletondevelopment, and for normal development of the respiratory tract(By similarity). Required for activation of RPS6KB1 in response toTNF signaling. Modulates TRAF6 functions. {ECO:0000250,ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526,ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600,ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAF4_FASN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAF4_FASN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAF4RPS6KB1, NCF1, NGFR, LTBR, TRIM37, USP7, SMURF1, CENPE, PRMT5, MYH9, KIF11, PSMC3, CALCOCO2, NPAS2, PDE4DIP, GPRASP1, FTH1, NCF2, TRAF6, TICAM1, IRAK1, MAP3K4, TRAF4, CD40, RIPK2, NOD1, NOD2, TNFRSF9, TNFRSF4, GP1BB, GP6, TGFB1I1, PTK2B, UBE2O, ZNF512B, SMURF2, CHUK, CBL, RNF114, CBLC, DTX3, KDM1A, TGFBR1, TGFBR2, USP15, MAP3K7, ARNT2, TRAF2, BYSL, KRT31, QARS, TP53BP2, TYK2, SUMO1, ZNF3, UBL4A, NOS1AP, MRPL28, WWP1, WWP2, BAHD1, EXOC7, GORASP2, TBC1D7, ISYNA1, ZNF581, WBP11, ALKBH4, SPDL1, BANP, HOMEZ, FBXL18, KRT40, UBL4B, BCL6B, KANSL1, PKD1P1, REXO1L6P, SUZ12, BMI1, RPL14, CATSPER4, HIP1R, FAM90A1, FAM214B, AKT1, CTNNB1, MAGEC2, FAT1, CTAGE5FASNFASN, EWSR1, USP2, HDAC5, PCK1, RAD21, NDRG1, MAPK3, ARRB1, ARRB2, SIRT7, TSG101, ISG15, CUL3, CDK2, DCUN1D1, SHC1, AP2M1, EMD, TP53BP1, EIF4A3, MAGOH, PTPN11, SMURF1, HSP90AB1, HSP90AA1, FN1, VCAM1, NOS2, NPM1, LMNA, PRR12, YWHAQ, FBXO6, CAP1, KIAA1598, SIRT1, TPM3, TPM4, LGR4, PHKG2, ILK, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, PTGR2, KIF3A, IMPDH1, HAUS4, TEAD3, YAP1, ABCC1, AHSA1, ASNS, CARM1, CCT6A, CCT6B, CYP27A1, HSD17B12, PC, PEF1, PIK3C2B, GFPT1, GFPT2, HSPBP1, MTCH1, TARBP1, NTRK1, AKT1, PTEN, HSPA5, KIF11, DNAJC7, IRF3, FOXI1, FOXI2, CRY1, CRY2, FOXL1, MCM2, SNW1, CDC5L, ZNF746, CDH1, USP22, CYLD, COX15, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, VHL, CAD, HIF1A, BRCA1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAF4_FASN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFASNP49327DB01083OrlistatFatty acid synthasesmall moleculeapproved|investigational

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RelatedDiseases for TRAF4_FASN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFASNC0025202melanoma3CTD_human
TgeneFASNC2239176Liver carcinoma3CTD_human
TgeneFASNC1458155Mammary Neoplasms2CTD_human
TgeneFASNC0007193Cardiomyopathy, Dilated1CTD_human
TgeneFASNC0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneFASNC0018801Heart failure1CTD_human
TgeneFASNC0022661Kidney Failure, Chronic1CTD_human
TgeneFASNC0023827liposarcoma1CTD_human
TgeneFASNC0028754Obesity1CTD_human
TgeneFASNC0086132Depressive Symptoms1PSYGENET
TgeneFASNC0919267ovarian neoplasm1CTD_human
TgeneFASNC0948089Acute Coronary Syndrome1CTD_human
TgeneFASNC3714756Intellectual Disability1CTD_human
TgeneFASNC4277682Chemical and Drug Induced Liver Injury1CTD_human