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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39340

FusionGeneSummary for TRAF3_MYO16

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3_MYO16
Fusion gene ID: 39340
HgeneTgene
Gene symbol

TRAF3

MYO16

Gene ID

7187

23026

Gene nameTNF receptor associated factor 3myosin XVI
SynonymsCAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118MYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Cytomap

14q32.32

13q33.3

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
Modification date2018052720180519
UniProtAcc

Q13114

Q9Y6X6

Ensembl transtripts involved in fusion geneENST00000560371, ENST00000347662, 
ENST00000392745, ENST00000539721, 
ENST00000351691, 
ENST00000356711, 
ENST00000251041, ENST00000357550, 
ENST00000457511, ENST00000467639, 
Fusion gene scores* DoF score12 X 6 X 10=72010 X 8 X 9=720
# samples 1310
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRAF3 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A400-01ATRAF3chr14

103352606

+MYO16chr13

109318234

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000560371ENST00000356711TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000560371ENST00000251041TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000560371ENST00000357550TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000560371ENST00000457511TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000560371ENST00000467639TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000347662ENST00000356711TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000347662ENST00000251041TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000347662ENST00000357550TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000347662ENST00000457511TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000347662ENST00000467639TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000392745ENST00000356711TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000392745ENST00000251041TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000392745ENST00000357550TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000392745ENST00000457511TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000392745ENST00000467639TRAF3chr14

103352606

+MYO16chr13

109318234

+
intron-5UTRENST00000539721ENST00000356711TRAF3chr14

103352606

+MYO16chr13

109318234

+
intron-5UTRENST00000539721ENST00000251041TRAF3chr14

103352606

+MYO16chr13

109318234

+
intron-5UTRENST00000539721ENST00000357550TRAF3chr14

103352606

+MYO16chr13

109318234

+
intron-intronENST00000539721ENST00000457511TRAF3chr14

103352606

+MYO16chr13

109318234

+
intron-intronENST00000539721ENST00000467639TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000351691ENST00000356711TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000351691ENST00000251041TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-5UTRENST00000351691ENST00000357550TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000351691ENST00000457511TRAF3chr14

103352606

+MYO16chr13

109318234

+
5CDS-intronENST00000351691ENST00000467639TRAF3chr14

103352606

+MYO16chr13

109318234

+

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FusionProtFeatures for TRAF3_MYO16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3

Q13114

MYO16

Q9Y6X6

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAF3_MYO16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAF3_MYO16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAF3TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPCMYO16NRXN1, NCKAP1, CYFIP2, CYFIP1, PIK3R1, ARHGAP26, ACOT9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAF3_MYO16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAF3_MYO16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRAF3C3553868HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 31UNIPROT
TgeneMYO16C0036341Schizophrenia1PSYGENET