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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39336

FusionGeneSummary for TRAF3_IFNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRAF3_IFNL1
Fusion gene ID: 39336
HgeneTgene
Gene symbol

TRAF3

IFNL1

Gene ID

7187

282618

Gene nameTNF receptor associated factor 3interferon lambda 1
SynonymsCAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118IL-29|IL29
Cytomap

14q32.32

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3interferon lambda-1IFN-lambda-1cytokine Zcyto21interleukin 29 (interferon, lambda 1)interleukin-29
Modification date2018052720180523
UniProtAcc

Q13114

Q8IU54

Ensembl transtripts involved in fusion geneENST00000560371, ENST00000347662, 
ENST00000392745, ENST00000539721, 
ENST00000351691, 
ENST00000333625, 
Fusion gene scores* DoF score12 X 6 X 10=7204 X 1 X 3=12
# samples 134
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TRAF3 [Title/Abstract] AND IFNL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFNL1

GO:0002829

negative regulation of type 2 immune response

19346497

TgeneIFNL1

GO:0008285

negative regulation of cell proliferation

15166220|15899585

TgeneIFNL1

GO:0032696

negative regulation of interleukin-13 production

19346497

TgeneIFNL1

GO:0032714

negative regulation of interleukin-5 production

19346497

TgeneIFNL1

GO:0032729

positive regulation of interferon-gamma production

19346497

TgeneIFNL1

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

15166220

TgeneIFNL1

GO:0043381

negative regulation of memory T cell differentiation

19346497

TgeneIFNL1

GO:0045345

positive regulation of MHC class I biosynthetic process

12483210

TgeneIFNL1

GO:0045581

negative regulation of T cell differentiation

19346497

TgeneIFNL1

GO:0045892

negative regulation of transcription, DNA-templated

19346497

TgeneIFNL1

GO:0045893

positive regulation of transcription, DNA-templated

12483210

TgeneIFNL1

GO:0046427

positive regulation of JAK-STAT cascade

12483210

TgeneIFNL1

GO:0051607

defense response to virus

12469119


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0724-01ATRAF3chr14

103244012

+IFNL1chr19

39787445

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000560371ENST00000333625TRAF3chr14

103244012

+IFNL1chr19

39787445

+
5UTR-3CDSENST00000347662ENST00000333625TRAF3chr14

103244012

+IFNL1chr19

39787445

+
5UTR-3CDSENST00000392745ENST00000333625TRAF3chr14

103244012

+IFNL1chr19

39787445

+
5UTR-3CDSENST00000539721ENST00000333625TRAF3chr14

103244012

+IFNL1chr19

39787445

+
intron-3CDSENST00000351691ENST00000333625TRAF3chr14

103244012

+IFNL1chr19

39787445

+

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FusionProtFeatures for TRAF3_IFNL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3

Q13114

IFNL1

Q8IU54

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}. Cytokine with antiviral, antitumour and immunomodulatoryactivities. Plays a critical role in the antiviral host defense,predominantly in the epithelial tissues. Acts as a ligand for theheterodimeric class II cytokine receptor composed of IL10RB andIFNLR1, and receptor engagement leads to the activation of theJAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has arestricted receptor distribution and therefore restricted targets:is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specificexpression of its receptor IFNLR1. Exerts an immunomodulatoryeffect by up-regulating MHC class I antigen expression.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRAF3_IFNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRAF3_IFNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRAF3TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPCIFNL1IFNL2, ATP2B2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRAF3_IFNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRAF3_IFNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRAF3C3553868HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 31UNIPROT