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Fusion gene ID: 39324 |
FusionGeneSummary for TRAF2_DENND1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRAF2_DENND1C | Fusion gene ID: 39324 | Hgene | Tgene | Gene symbol | TRAF2 | DENND1C | Gene ID | 10010 | 79958 |
| Gene name | TRAF family member associated NFKB activator | DENN domain containing 1C | |
| Synonyms | I-TRAF|ITRAF|TRAF2 | FAM31C | |
| Cytomap | 2q24.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TRAF family member-associated NF-kappa-B activatorTRAF-interacting protein | DENN domain-containing protein 1CDENN/MADD domain containing 1Cconnecdenn 3family with sequence similarity 31, member C | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q12933 | Q8IV53 | |
| Ensembl transtripts involved in fusion gene | ENST00000536468, ENST00000247668, ENST00000359662, ENST00000482854, | ENST00000381480, ENST00000543576, ENST00000591030, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 1=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: TRAF2 [Title/Abstract] AND DENND1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI031313 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000536468 | ENST00000381480 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| In-frame | ENST00000536468 | ENST00000543576 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| 5CDS-intron | ENST00000536468 | ENST00000591030 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| In-frame | ENST00000247668 | ENST00000381480 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| In-frame | ENST00000247668 | ENST00000543576 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| 5CDS-intron | ENST00000247668 | ENST00000591030 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| In-frame | ENST00000359662 | ENST00000381480 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| In-frame | ENST00000359662 | ENST00000543576 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| 5CDS-intron | ENST00000359662 | ENST00000591030 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| intron-3CDS | ENST00000482854 | ENST00000381480 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| intron-3CDS | ENST00000482854 | ENST00000543576 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
| intron-intron | ENST00000482854 | ENST00000591030 | TRAF2 | chr9 | 139818424 | - | DENND1C | chr19 | 6475907 | + |
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FusionProtFeatures for TRAF2_DENND1C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRAF2 | DENND1C |
| Regulates activation of NF-kappa-B and JNK and plays acentral role in the regulation of cell survival and apoptosis.Required for normal antibody isotype switching from IgM to IgG.Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 andTICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination oftarget proteins by bringing them into contact with other E3ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels byinhibiting their autoubiquitination and subsequent degradation;this does not depend on the TRAF2 RING-type zinc finger domain.Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.{ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851,ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689,ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425,ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754,ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526,ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214,ECO:0000269|PubMed:23453969}. | Guanine nucleotide exchange factor (GEF) which mayactivate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP toGTP, converting inactive GDP-bound Rab proteins into their activeGTP-bound form. {ECO:0000269|PubMed:20154091,ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRAF2_DENND1C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRAF2_DENND1C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRAF2_DENND1C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAF2_DENND1C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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