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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3928

FusionGeneSummary for BCAR3_BCAR3

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAR3_BCAR3
Fusion gene ID: 3928
HgeneTgene
Gene symbol

BCAR3

BCAR3

Gene ID

8412

8412

Gene nameBCAR3, NSP family adaptor proteinBCAR3, NSP family adaptor protein
SynonymsAND-34|NSP2|SH2D3BAND-34|NSP2|SH2D3B
Cytomap

1p22.1

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer anti-estrogen resistance protein 3SH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistance 3)novel SH2-containing protein breast cancer anti-estrogen resistance protein 3SH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistance 3)novel SH2-containing protein
Modification date2018051920180519
UniProtAcc

O75815

O75815

Ensembl transtripts involved in fusion geneENST00000260502, ENST00000370244, 
ENST00000370243, ENST00000370247, 
ENST00000539242, ENST00000466632, 
ENST00000260502, ENST00000370244, 
ENST00000370243, ENST00000370247, 
ENST00000539242, ENST00000466632, 
Fusion gene scores* DoF score7 X 8 X 6=3365 X 4 X 3=60
# samples 85
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCAR3 [Title/Abstract] AND BCAR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA311930BCAR3chr1

94027583

+BCAR3chr1

94027783

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000260502ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000260502ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000260502ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000260502ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000260502ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000260502ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370244ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370244ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370244ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370244ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370244ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000370244ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370243ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370243ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370243ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370243ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370243ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000370243ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370247ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370247ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370247ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370247ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000370247ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000370247ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000539242ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000539242ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000539242ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000539242ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000539242ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000539242ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000466632ENST00000260502BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000466632ENST00000370244BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000466632ENST00000370243BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000466632ENST00000370247BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-3UTRENST00000466632ENST00000539242BCAR3chr1

94027583

+BCAR3chr1

94027783

-
intron-intronENST00000466632ENST00000466632BCAR3chr1

94027583

+BCAR3chr1

94027783

-

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FusionProtFeatures for BCAR3_BCAR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAR3

O75815

BCAR3

O75815

May act as an adapter protein and couple activatedgrowth factor receptors to a signaling pathway that regulates theproliferation in breast cancer cells. When overexpressed, itconfers anti-estrogen resistance in breast cancer cell lines. Mayalso be regulated by cellular adhesion to extracellular matrixproteins. {ECO:0000269|PubMed:9582273}. May act as an adapter protein and couple activatedgrowth factor receptors to a signaling pathway that regulates theproliferation in breast cancer cells. When overexpressed, itconfers anti-estrogen resistance in breast cancer cell lines. Mayalso be regulated by cellular adhesion to extracellular matrixproteins. {ECO:0000269|PubMed:9582273}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCAR3_BCAR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCAR3_BCAR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCAR3_BCAR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCAR3_BCAR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAR3C0236969Substance-Related Disorders1CTD_human
HgeneBCAR3C1458155Mammary Neoplasms1CTD_human
TgeneBCAR3C0236969Substance-Related Disorders1CTD_human
TgeneBCAR3C1458155Mammary Neoplasms1CTD_human