	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 39276

FusionGeneSummary for TPT1_PLEKHB2

Fusion gene summary

Fusion gene information	Fusion gene name: TPT1_PLEKHB2
	Fusion gene ID: 39276
		Hgene	Tgene
	Gene symbol	TPT1	PLEKHB2
	Gene ID	7178	55041
	Gene name	tumor protein, translationally-controlled 1	pleckstrin homology domain containing B2
	Synonyms	HRF\|TCTP\|p02\|p23	EVT2
	Cytomap	13q14.13	2q21.1
	Type of gene	protein-coding	protein-coding
	Description	translationally-controlled tumor proteinfortilinhistamine-releasing factor	pleckstrin homology domain-containing family B member 2PH domain-containing family B member 2evectin-2pleckstrin homology domain containing, family B (evectins) member 2
	Modification date	20180523	20180523
	UniProtAcc	P13693	Q96CS7
	Ensembl transtripts involved in fusion gene	ENST00000379056, ENST00000529421, ENST00000530705, ENST00000379060, ENST00000379055, ENST00000309246,	ENST00000404460, ENST00000303908, ENST00000409158, ENST00000403716, ENST00000234115, ENST00000439822, ENST00000487980, ENST00000438882, ENST00000538982, ENST00000409612, ENST00000409279,
Fusion gene scores	* DoF score	13 X 6 X 11=858	13 X 3 X 10=390
	# samples	17	15
	** MAII score	log2(17/858*10)=-2.33544290136184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/390*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TPT1 [Title/Abstract] AND PLEKHB2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-HC-A6HY-01A	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000379056	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
5CDS-intron	ENST00000379056	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000529421	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000530705	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379060	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000379055	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000404460	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000303908	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000409158	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000403716	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000234115	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000439822	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000487980	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000438882	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000538982	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000409612	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+
intron-intron	ENST00000309246	ENST00000409279	TPT1	chr13	45911008	-	PLEKHB2	chr2	131876464	+

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FusionProtFeatures for TPT1_PLEKHB2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TPT1 P13693	PLEKHB2 Q96CS7
Involved in calcium binding and microtubulestabilization.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TPT1_PLEKHB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPT1_PLEKHB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
TPT1	VHL, FANCA, IKBKG, CALM1, RBBP6, DBN1, RPLP1, TP53, SPP1, CDK2, MDM2, APP, TBCB, LIG4, NKX3-1, BAG3, PER2, BCL2L1, MCL1, TUBB2A, EEF1D, TRIP13, NOTCH3, HSPB1, CALR, NPEPL1, SAMD9, MSH2, MYCBP, LACC1, CST7, EEF1A2, EEF1B2, FOXA1, MCPH1	PLEKHB2	KRT85, KRT31, KRT82, KRT34, UPF1, CDA, BHLHE40, DAZAP2, STAM2, EPN1, C1orf94, MAP3K1, TMEM231, CST6, ITCH, NCCRP1, ALOXE3, CGRRF1, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TPT1_PLEKHB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	TPT1	P13693	DB11093	Calcium Citrate	Translationally-controlled tumor protein	small molecule	approved
Hgene	TPT1	P13693	DB11348	Calcium Phosphate	Translationally-controlled tumor protein	small molecule	approved

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RelatedDiseases for TPT1_PLEKHB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TPT1	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	TPT1	C0036341	Schizophrenia	1	PSYGENET

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Fusion gene ID: 39276

FusionGeneSummary for TPT1_PLEKHB2

FusionProtFeatures for TPT1_PLEKHB2

FusionGeneSequence for TPT1_PLEKHB2

FusionGenePPI for TPT1_PLEKHB2

RelatedDrugs for TPT1_PLEKHB2

RelatedDiseases for TPT1_PLEKHB2