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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39272

FusionGeneSummary for TPT1_MME

check button Fusion gene summary
Fusion gene informationFusion gene name: TPT1_MME
Fusion gene ID: 39272
HgeneTgene
Gene symbol

TPT1

MME

Gene ID

7178

4321

Gene nametumor protein, translationally-controlled 1matrix metallopeptidase 12
SynonymsHRF|TCTP|p02|p23HME|ME|MME|MMP-12
Cytomap

13q14.13

11q22.2

Type of geneprotein-codingprotein-coding
Descriptiontranslationally-controlled tumor proteinfortilinhistamine-releasing factormacrophage metalloelastasematrix metallopeptidase 12 (macrophage elastase)matrix metalloproteinase 12 (macrophage elastase)
Modification date2018052320180522
UniProtAcc

P13693

P08473

Ensembl transtripts involved in fusion geneENST00000379056, ENST00000529421, 
ENST00000530705, ENST00000379060, 
ENST00000379055, ENST00000309246, 
ENST00000492661, ENST00000460393, 
ENST00000382989, ENST00000462745, 
ENST00000493237, ENST00000360490, 
ENST00000477669, 
Fusion gene scores* DoF score13 X 6 X 11=8583 X 3 X 2=18
# samples 173
** MAII scorelog2(17/858*10)=-2.33544290136184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPT1 [Title/Abstract] AND MME [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMME

GO:0006508

proteolysis

24784232

TgeneMME

GO:0035313

wound healing, spreading of epidermal cells

15802269

TgeneMME

GO:0060054

positive regulation of epithelial cell proliferation involved in wound healing

15802269


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-DY-A1DD-01ATPT1chr13

45911008

-MMEchr3

154801733

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379056ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
5CDS-intronENST00000379056ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000529421ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000530705ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379060ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000379055ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000492661TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000460393TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000382989TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000462745TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000493237TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000360490TPT1chr13

45911008

-MMEchr3

154801733

+
intron-intronENST00000309246ENST00000477669TPT1chr13

45911008

-MMEchr3

154801733

+

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FusionProtFeatures for TPT1_MME


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPT1

P13693

MME

P08473

Involved in calcium binding and microtubulestabilization. Thermolysin-like specificity, but is almost confined onacting on polypeptides of up to 30 amino acids (PubMed:15283675,PubMed:8168535). Biologically important in the destruction ofopioid peptides such as Met- and Leu-enkephalins by cleavage of aGly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1,angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved inthe degradation of atrial natriuretic factor (ANF)(PubMed:2531377, PubMed:2972276). Displays UV-inducible elastaseactivity toward skin preelastic and elastic fibers(PubMed:20876573). {ECO:0000269|PubMed:15283675,ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573,ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448,ECO:0000269|PubMed:2972276}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPT1_MME


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPT1_MME


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPT1VHL, FANCA, IKBKG, CALM1, RBBP6, DBN1, RPLP1, TP53, SPP1, CDK2, MDM2, APP, TBCB, LIG4, NKX3-1, BAG3, PER2, BCL2L1, MCL1, TUBB2A, EEF1D, TRIP13, NOTCH3, HSPB1, CALR, NPEPL1, SAMD9, MSH2, MYCBP, LACC1, CST7, EEF1A2, EEF1B2, FOXA1, MCPH1MMECSNK2A1, LYN, CD4, SLC9A3R1, NDUFA9, UBAC2, ATP12A, RPS10, RUVBL2, UTRN, MRPL44, SDF4, FAHD1, FAAH, ITFG3, CPSF6, MRPS25, SRSF11, DNAJB12, LAMTOR1, RAP2B, SSR4, RUVBL1, LMNA, PCNA, NUCKS1, METTL7A, VDAC2, TNPO1, SLC16A1, HSPB1, ZMPSTE24, FECH, FOLH1, FLOT2, PDIA5, HSPA1A, HSPA8, TM9SF1, NDUFA10, RBM39, NDUFB4, KBTBD3, MTHFD1, RPS23, RPL30, ATP5J2, ARL1, XRCC5, IMPDH2, HIST1H2AG, NOLC1, TUBB8, ARMC10, MRVI1, CDK5RAP3, IRAK2, MTDH, MYH9, ALDH3A2, LONP1, FAM83F, POTEI, OPA1, CLEC4M, EEF1A1, KRT10, NNT, INPP5D, RGPD6, HSPA4, NDRG1, HDAC8, AGT, NPPA, MME, GLT8D2, LEMD3, PXMP2, POMGNT1, SLC10A7, STARD3, MANEAL, TENM3, TMEM223, ACSL4, B4GALT1, EPHB4, LEMD2, SLC22A18, PLD6, PAM16, MANEA, FAM213A, GALNT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPT1_MME


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTPT1P13693DB11093Calcium CitrateTranslationally-controlled tumor proteinsmall moleculeapproved
HgeneTPT1P13693DB11348Calcium PhosphateTranslationally-controlled tumor proteinsmall moleculeapproved
TgeneMMEP08473DB09292SacubitrilNeprilysinsmall moleculeapproved

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RelatedDiseases for TPT1_MME


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPT1C0033578Prostatic Neoplasms1CTD_human
HgeneTPT1C0036341Schizophrenia1PSYGENET
TgeneMMEC0011882Diabetic Neuropathies1CTD_human
TgeneMMEC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMMEC0033578Prostatic Neoplasms1CTD_human
TgeneMMEC0273115Lung Injury1CTD_human
TgeneMMEC1458155Mammary Neoplasms1CTD_human
TgeneMMEC1565489Renal Insufficiency1CTD_human
TgeneMMEC2316212Cryopyrin-Associated Periodic Syndromes1CTD_human