|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39265 |
FusionGeneSummary for TPST2_CRYBB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPST2_CRYBB1 | Fusion gene ID: 39265 | Hgene | Tgene | Gene symbol | TPST2 | CRYBB1 | Gene ID | 8459 | 1414 |
| Gene name | tyrosylprotein sulfotransferase 2 | crystallin beta B1 | |
| Synonyms | TANGO13B|TPST-2 | CATCN3|CTRCT17 | |
| Cytomap | 22q12.1 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein-tyrosine sulfotransferase 2transport and golgi organization 13 homolog Btyrosylprotein phosphotransferase 2 | beta-crystallin B1beta-B1 crystallineye lens structural protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | O60704 | P53674 | |
| Ensembl transtripts involved in fusion gene | ENST00000338754, ENST00000398110, ENST00000403880, | ENST00000215939, | |
| Fusion gene scores | * DoF score | 1 X 2 X 2=4 | 4 X 3 X 4=48 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/4*10)=2.90689059560852 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TPST2 [Title/Abstract] AND CRYBB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TPST2 | GO:0006478 | peptidyl-tyrosine sulfation | 9733778|23481380 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-ZS-A9CF-02A | TPST2 | chr22 | 26932254 | - | CRYBB1 | chr22 | 26997985 | - |
| TCGA | RV | LIHC | TCGA-ZS-A9CF-01A | TPST2 | chr22 | 26932254 | - | CRYBB1 | chr22 | 26997985 | - |
| TCGA | RV | UCEC | TCGA-EO-A3KW-01A | TPST2 | chr22 | 26986017 | - | CRYBB1 | chr22 | 27012302 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000338754 | ENST00000215939 | TPST2 | chr22 | 26932254 | - | CRYBB1 | chr22 | 26997985 | - |
| Frame-shift | ENST00000398110 | ENST00000215939 | TPST2 | chr22 | 26932254 | - | CRYBB1 | chr22 | 26997985 | - |
| Frame-shift | ENST00000403880 | ENST00000215939 | TPST2 | chr22 | 26932254 | - | CRYBB1 | chr22 | 26997985 | - |
| 5UTR-5UTR | ENST00000338754 | ENST00000215939 | TPST2 | chr22 | 26986017 | - | CRYBB1 | chr22 | 27012302 | - |
| intron-5UTR | ENST00000398110 | ENST00000215939 | TPST2 | chr22 | 26986017 | - | CRYBB1 | chr22 | 27012302 | - |
| intron-5UTR | ENST00000403880 | ENST00000215939 | TPST2 | chr22 | 26986017 | - | CRYBB1 | chr22 | 27012302 | - |
Top |
FusionProtFeatures for TPST2_CRYBB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TPST2 | CRYBB1 |
| Catalyzes the O-sulfation of tyrosine residues withinacidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate(PAPS) as cosubstrate. {ECO:0000269|PubMed:9733778}. | Crystallins are the dominant structural components ofthe vertebrate eye lens. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 285_294 | 347 | 592 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 78_82 | 347 | 592 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 285_294 | 347 | 496 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 78_82 | 347 | 496 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 285_294 | 347 | 514 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 78_82 | 347 | 514 | Region | PAPS binding |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 1_8 | 347 | 592 | Topological domain | Cytoplasmic |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 1_8 | 347 | 496 | Topological domain | Cytoplasmic |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 1_8 | 347 | 514 | Topological domain | Cytoplasmic |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 9_25 | 347 | 592 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 9_25 | 347 | 496 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 9_25 | 347 | 514 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 149_190 | 144 | 253 | Domain | Beta/gamma crystallin 'Greek key' 3 |
| Tgene | >CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 191_233 | 144 | 253 | Domain | Beta/gamma crystallin 'Greek key' 4 |
| Tgene | >CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 144_148 | 144 | 253 | Region | Note=Connecting peptide |
| Tgene | >CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 235_252 | 144 | 253 | Region | Note=C-terminal arm |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 26_377 | 347 | 592 | Topological domain | Lumenal |
| Hgene | >TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 26_377 | 347 | 496 | Topological domain | Lumenal |
| Hgene | >TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 26_377 | 347 | 514 | Topological domain | Lumenal |
| Tgene | CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 59_98 | 144 | 253 | Domain | Beta/gamma crystallin 'Greek key' 1 |
| Tgene | CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 99_143 | 144 | 253 | Domain | Beta/gamma crystallin 'Greek key' 2 |
| Tgene | CRYBB1 | chr22:26932254 | chr22:26997985 | ENST00000215939 | - | 3 | 6 | 2_58 | 144 | 253 | Region | Note=N-terminal arm |
Top |
FusionGeneSequence for TPST2_CRYBB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TPST2_CRYBB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TPST2 | SLC39A4, PTCH1, HTR3C, CSGALNACT2, SLC39A9, TCTN2, CHRND, HTR3A, CHRNA3, MRAP2 | CRYBB1 | TERF1, TERF2IP, CRYBA1, PCBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000338754 | - | 4 | 7 | 101_105 | 347 | 592 | peptide substrate |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000398110 | - | 4 | 7 | 101_105 | 347 | 496 | peptide substrate |
| Hgene | TPST2 | chr22:26932254 | chr22:26997985 | ENST00000403880 | - | 5 | 8 | 101_105 | 347 | 514 | peptide substrate |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TPST2_CRYBB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TPST2_CRYBB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CRYBB1 | C0086543 | Cataract | 1 | CTD_human;HPO |
| Tgene | CRYBB1 | C3888124 | CATARACT 17, MULTIPLE TYPES | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|