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Fusion gene ID: 39264 |
FusionGeneSummary for TPST1_TRIM24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPST1_TRIM24 | Fusion gene ID: 39264 | Hgene | Tgene | Gene symbol | TPST1 | TRIM24 | Gene ID | 8460 | 8805 |
| Gene name | tyrosylprotein sulfotransferase 1 | tripartite motif containing 24 | |
| Synonyms | TANGO13A | PTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1 | |
| Cytomap | 7q11.21 | 7q33-q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein-tyrosine sulfotransferase 1TPST-1transport and golgi organization 13 homolog A | transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O60507 | O15164 | |
| Ensembl transtripts involved in fusion gene | ENST00000304842, ENST00000480281, | ENST00000343526, ENST00000415680, ENST00000497516, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TPST1 [Title/Abstract] AND TRIM24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TPST1 | GO:0006478 | peptidyl-tyrosine sulfation | 9501187 |
| Tgene | TRIM24 | GO:0016567 | protein ubiquitination | 19556538 |
| Tgene | TRIM24 | GO:0071391 | cellular response to estrogen stimulus | 21164480 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-KD-A5QS-01A | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000304842 | ENST00000343526 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| Frame-shift | ENST00000304842 | ENST00000415680 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| 5CDS-3UTR | ENST00000304842 | ENST00000497516 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| 3UTR-3CDS | ENST00000480281 | ENST00000343526 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| 3UTR-3CDS | ENST00000480281 | ENST00000415680 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
| 3UTR-3UTR | ENST00000480281 | ENST00000497516 | TPST1 | chr7 | 65751696 | + | TRIM24 | chr7 | 138189035 | + |
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FusionProtFeatures for TPST1_TRIM24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TPST1 | TRIM24 |
| Catalyzes the O-sulfation of tyrosine residues withinacidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate(PAPS) as cosubstrate. {ECO:0000269|PubMed:28821720,ECO:0000269|PubMed:9501187, ECO:0000269|PubMed:9733778}. | Transcriptional coactivator that interacts with numerousnuclear receptors and coactivators and modulates the transcriptionof target genes. Interacts with chromatin depending on histone H3modifications, having the highest affinity for histone H3 that isboth unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotesubiquitination and proteasomal degradation of p53/TP53. Plays arole in the regulation of cell proliferation and apoptosis, atleast in part via its effects on p53/TP53 levels. Up-regulatesligand-dependent transcription activation by AR, GCR/NR3C1,thyroid hormone receptor (TR) and ESR1. Modulates transcriptionactivation by retinoic acid (RA) receptors, including RARA. Playsa role in regulating retinoic acid-dependent proliferation ofhepatocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538,ECO:0000269|PubMed:21164480}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TPST1_TRIM24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TPST1_TRIM24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TPST1 | ACTB, GINM1, CD97, SCGB2A2, B2M | TRIM24 | ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TPST1_TRIM24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPST1_TRIM24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TRIM24 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | TRIM24 | C2239176 | Liver carcinoma | 1 | CTD_human |
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