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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39256

FusionGeneSummary for TPPP3_ANKRD30A

check button Fusion gene summary
Fusion gene informationFusion gene name: TPPP3_ANKRD30A
Fusion gene ID: 39256
HgeneTgene
Gene symbol

TPPP3

ANKRD30A

Gene ID

51673

91074

Gene nametubulin polymerization promoting protein family member 3ankyrin repeat domain 30A
SynonymsCGI-38|TPPP/p20|p20|p25gammaNY-BR-1
Cytomap

16q22.1

10p11.21

Type of geneprotein-codingprotein-coding
Descriptiontubulin polymerization-promoting protein family member 3brain specific proteinankyrin repeat domain-containing protein 30Aserologically defined breast cancer antigen NY-BR-1
Modification date2018052320180519
UniProtAcc

Q9BW30

Q9BXX3

Ensembl transtripts involved in fusion geneENST00000393957, ENST00000564104, 
ENST00000290942, ENST00000562206, 
ENST00000374660, ENST00000361713, 
ENST00000602533, ENST00000475522, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: TPPP3 [Title/Abstract] AND ANKRD30A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPPP3

GO:0001578

microtubule bundle formation

17105200


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF995465TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000393957ENST00000374660TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000393957ENST00000361713TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000393957ENST00000602533TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000393957ENST00000475522TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000564104ENST00000374660TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000564104ENST00000361713TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000564104ENST00000602533TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000564104ENST00000475522TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000290942ENST00000374660TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000290942ENST00000361713TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000290942ENST00000602533TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000290942ENST00000475522TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000562206ENST00000374660TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000562206ENST00000361713TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000562206ENST00000602533TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+
intron-intronENST00000562206ENST00000475522TPPP3chr16

67424491

-ANKRD30Achr10

37436663

+

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FusionProtFeatures for TPPP3_ANKRD30A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPPP3

Q9BW30

ANKRD30A

Q9BXX3

Binds tubulin and has microtubule bundling activity. Mayplay a role in cell proliferation and mitosis.{ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPPP3_ANKRD30A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPPP3_ANKRD30A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPPP3_ANKRD30A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPPP3_ANKRD30A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource