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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39254

FusionGeneSummary for TPP2_MYO5B

check button Fusion gene summary
Fusion gene informationFusion gene name: TPP2_MYO5B
Fusion gene ID: 39254
HgeneTgene
Gene symbol

TPP2

MYO5B

Gene ID

7174

4645

Gene nametripeptidyl peptidase 2myosin VB
SynonymsTPP-2|TPP-II|TPPII-
Cytomap

13q33.1

18q21.1

Type of geneprotein-codingprotein-coding
Descriptiontripeptidyl-peptidase 2tripeptidyl aminopeptidasetripeptidyl-peptidase IIunconventional myosin-VbMYO5B variant proteinmyosin-Vb
Modification date2018051920180519
UniProtAcc

P29144

Q9ULV0

Ensembl transtripts involved in fusion geneENST00000376065, ENST00000376052, 
ENST00000466153, 
ENST00000285039, 
ENST00000324581, ENST00000592688, 
ENST00000587895, 
Fusion gene scores* DoF score2 X 2 X 1=49 X 9 X 7=567
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/567*10)=-2.36584521141757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPP2 [Title/Abstract] AND MYO5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF996738TPP2chr13

103278434

+MYO5Bchr18

47519516

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000376065ENST00000285039TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376065ENST00000324581TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376065ENST00000592688TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376065ENST00000587895TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376052ENST00000285039TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376052ENST00000324581TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376052ENST00000592688TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000376052ENST00000587895TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000466153ENST00000285039TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000466153ENST00000324581TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000466153ENST00000592688TPP2chr13

103278434

+MYO5Bchr18

47519516

+
intron-intronENST00000466153ENST00000587895TPP2chr13

103278434

+MYO5Bchr18

47519516

+

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FusionProtFeatures for TPP2_MYO5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPP2

P29144

MYO5B

Q9ULV0

Component of the proteolytic cascade acting downstreamof the 26S proteasome in the ubiquitin-proteasome pathway. May beable to complement the 26S proteasome function to some extentunder conditions in which the latter is inhibited. Stimulatesadipogenesis (By similarity). {ECO:0000250}. May be involved in vesicular trafficking via itsassociation with the CART complex. The CART complex is necessaryfor efficient transferrin receptor recycling but not for EGFRdegradation. Required in a complex with RAB11A and RAB11FIP2 forthe transport of NPC1L1 to the plasma membrane. Together withRAB11A participates in CFTR trafficking to the plasma membrane andTF (transferrin) recycling in nonpolarized cells. Together withRAB11A and RAB8A participates in epithelial cell polarization.Together with RAB25 regulates transcytosis.{ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPP2_MYO5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPP2_MYO5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPP2_MYO5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPP2_MYO5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYO5BC0341306Microvillus inclusion disease5CTD_human;ORPHANET;UNIPROT
TgeneMYO5BC0011991Diarrhea1CTD_human
TgeneMYO5BC0021831Intestinal Diseases1CTD_human
TgeneMYO5BC0023903Liver neoplasms1CTD_human
TgeneMYO5BC0025521Inborn Errors of Metabolism1CTD_human
TgeneMYO5BC0036341Schizophrenia1PSYGENET
TgeneMYO5BC0236733Amphetamine-Related Disorders1CTD_human
TgeneMYO5BC0525045Mood Disorders1PSYGENET