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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39241

FusionGeneSummary for TPM4_INTS2

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM4_INTS2
Fusion gene ID: 39241
HgeneTgene
Gene symbol

TPM4

INTS2

Gene ID

7171

57508

Gene nametropomyosin 4integrator complex subunit 2
SynonymsHEL-S-108INT2|KIAA1287
Cytomap

19p13.12-p13.11

17q23.2

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108integrator complex subunit 2
Modification date2018052320180523
UniProtAcc

P67936

Q9H0H0

Ensembl transtripts involved in fusion geneENST00000344824, ENST00000538887, 
ENST00000300933, ENST00000591645, 
ENST00000444766, ENST00000251334, 
Fusion gene scores* DoF score10 X 9 X 4=3603 X 3 X 2=18
# samples 113
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPM4 [Title/Abstract] AND INTS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS2

GO:0016180

snRNA processing

16239144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FD-01ATPM4chr19

16187940

+INTS2chr17

59952399

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344824ENST00000444766TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000344824ENST00000251334TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000538887ENST00000444766TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000538887ENST00000251334TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000300933ENST00000444766TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000300933ENST00000251334TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000591645ENST00000444766TPM4chr19

16187940

+INTS2chr17

59952399

-
intron-3CDSENST00000591645ENST00000251334TPM4chr19

16187940

+INTS2chr17

59952399

-

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FusionProtFeatures for TPM4_INTS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPM4

P67936

INTS2

Q9H0H0

Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPM4_INTS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPM4_INTS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPM4TCERG1, TRIP6, PACSIN1, ARRB1, SP1, CDK2, AKT1, TPM3, TPM2, TPM1, SRXN1, HNRNPK, DBN1, ZYX, PCMT1, G3BP1, PSMD2, PSMA6, CDH2, SULT1A1, SERPINH1, ILF3, ILF2, TELO2, MYH9, PSMD1, SNRNP70, TXN2, SRSF2, PRKCDBP, CORO1C, TPM3P4, DCTN2, PSMC2, ATF2, PAN2, HDAC8, PARK2, CAP1, FASN, KIAA1598, SIRT1, TP53, LNX1, PYCARD, EGFR, ACTN1, ACTN2, COX5A, OSTF1, ACTN4, ATP1A1, ATP5F1, CENPE, CKB, COX4I1, MYH7B, NDUFB10, PSMA1, TBCD, NTRK1, ADD1, CAPZA2, FLNA, PPP1CB, PPP1CC, IQGAP1, SLC33A1, PDLIM7, MAPRE1, ANLN, MYO19, MYO18A, CFAP97, MCM2, SMURF1, ZNF131, DLST, UBE2AINTS2INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, CPSF3L, INTS7, INTS8, SNX4, ATP6V1B2, ATP6V1B1, SOX2, KDM1A, SUV39H1, CD274, FAS, SLAMF1, TGOLN2, SCN2B, ABCF3, C7orf26, ASUN, CKAP5, RPP30, PPP2CA, PPP2CB, PPP2R1A, VWA9, CD70, DKKL1, VSIG1, DPEP1, FAM174A, SLC15A1, APLNR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPM4_INTS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TPM4_INTS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM4C0003949Asbestosis1CTD_human
HgeneTPM4C0014859Esophageal Neoplasms1CTD_human
HgeneTPM4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM4C0027627Neoplasm Metastasis1CTD_human
HgeneTPM4C0029456Osteoporosis1CTD_human
HgeneTPM4C0032927Precancerous Conditions1CTD_human
HgeneTPM4C0043094Weight Gain1CTD_human
HgeneTPM4C0948089Acute Coronary Syndrome1CTD_human