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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39235

FusionGeneSummary for TPM3_KCNN3

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM3_KCNN3
Fusion gene ID: 39235
HgeneTgene
Gene symbol

TPM3

KCNN3

Gene ID

7170

3782

Gene nametropomyosin 3potassium calcium-activated channel subfamily N member 3
SynonymsCAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30KCa2.3|SK3|SKCA3|hSK3
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosismall conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member
Modification date2018052320180523
UniProtAcc

P06753

Q9UGI6

Ensembl transtripts involved in fusion geneENST00000368533, ENST00000469717, 
ENST00000330188, ENST00000341485, 
ENST00000341372, ENST00000328159, 
ENST00000271850, ENST00000302206, 
ENST00000368531, ENST00000323144, 
ENST00000368530, 
ENST00000271915, 
ENST00000361147, ENST00000358505, 
ENST00000515643, 
Fusion gene scores* DoF score7 X 6 X 6=2524 X 4 X 3=48
# samples 145
** MAII scorelog2(14/252*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPM3 [Title/Abstract] AND KCNN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-IS-A3K6-01ATPM3chr1

154141781

-KCNN3chr1

154794660

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368533ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000368533ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000368533ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000368533ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000469717ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000469717ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000469717ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000469717ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000330188ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000330188ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000330188ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000330188ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000341485ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000341485ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000341485ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000341485ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000341372ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000341372ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000341372ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000341372ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
Frame-shitENST00000328159ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
Frame-shitENST00000328159ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
5CDS-5UTRENST00000328159ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
5CDS-intronENST00000328159ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000271850ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000271850ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000271850ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000271850ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000302206ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000302206ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000302206ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000302206ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000368531ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000368531ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000368531ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000368531ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000323144ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-3CDSENST00000323144ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-5UTRENST00000323144ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
intron-intronENST00000323144ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-
Frame-shitENST00000368530ENST00000271915TPM3chr1

154141781

-KCNN3chr1

154794660

-
Frame-shitENST00000368530ENST00000361147TPM3chr1

154141781

-KCNN3chr1

154794660

-
5CDS-5UTRENST00000368530ENST00000358505TPM3chr1

154141781

-KCNN3chr1

154794660

-
5CDS-intronENST00000368530ENST00000515643TPM3chr1

154141781

-KCNN3chr1

154794660

-

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FusionProtFeatures for TPM3_KCNN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPM3

P06753

KCNN3

Q9UGI6

Forms a voltage-independent potassium channel activatedby intracellular calcium. Activation is followed by membranehyperpolarization. Thought to regulate neuronal excitability bycontributing to the slow component of synapticafterhyperpolarization. The channel is blocked by apamin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TPM3_KCNN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TPM3_KCNN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TPM3KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1KCNN3CALM1, APP, CAV1, DNM2, RAB5A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TPM3_KCNN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKCNN3Q9UGI6DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 3small moleculeapproved|investigational|vet_approved

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RelatedDiseases for TPM3_KCNN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM3C1836448Nemaline myopathy 19CTD_human;ORPHANET;UNIPROT
HgeneTPM3C0546264Congenital Fiber Type Disproportion5ORPHANET;UNIPROT
HgeneTPM3C0024667Animal Mammary Neoplasms2CTD_human
HgeneTPM3C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneTPM3C0001418Adenocarcinoma1CTD_human
HgeneTPM3C0009375Colonic Neoplasms1CTD_human
HgeneTPM3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM3C0038356Stomach Neoplasms1CTD_human
HgeneTPM3C0040136Thyroid Neoplasm1CTD_human
TgeneKCNN3C0005586Bipolar Disorder5PSYGENET
TgeneKCNN3C0036341Schizophrenia3PSYGENET
TgeneKCNN3C0004238Atrial Fibrillation1CTD_human