FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39174

FusionGeneSummary for TP63_CYTH3

check button Fusion gene summary
Fusion gene informationFusion gene name: TP63_CYTH3
Fusion gene ID: 39174
HgeneTgene
Gene symbol

TP63

CYTH3

Gene ID

8626

9265

Gene nametumor protein p63cytohesin 3
SynonymsAIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73LARNO3|GRP1|PSCD3|cytohesin-3
Cytomap

3q28

7p22.1

Type of geneprotein-codingprotein-coding
Descriptiontumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing proteincytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3
Modification date2018052120180519
UniProtAcc

Q9H3D4

O43739

Ensembl transtripts involved in fusion geneENST00000264731, ENST00000382063, 
ENST00000418709, ENST00000320472, 
ENST00000392460, ENST00000440651, 
ENST00000354600, ENST00000437221, 
ENST00000392463, ENST00000392461, 
ENST00000456148, ENST00000449992, 
ENST00000350796, ENST00000396741, 
ENST00000488964, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 2 X 3=18
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TP63 [Title/Abstract] AND CYTH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

HgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

HgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

HgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

HgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CV-6941-01ATP63chr3

189526315

+CYTH3chr7

6230162

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264731ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000264731ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000264731ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-3CDSENST00000382063ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-intronENST00000382063ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-intronENST00000382063ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000418709ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000418709ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000418709ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000320472ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000320472ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000320472ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000392460ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392460ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392460ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000440651ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000440651ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000440651ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000354600ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000354600ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000354600ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000437221ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000437221ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000437221ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000392463ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392463ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392463ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000392461ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392461ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000392461ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
Frame-shiftENST00000456148ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000456148ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
5CDS-intronENST00000456148ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-3CDSENST00000449992ENST00000350796TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-intronENST00000449992ENST00000396741TP63chr3

189526315

+CYTH3chr7

6230162

-
intron-intronENST00000449992ENST00000488964TP63chr3

189526315

+CYTH3chr7

6230162

-

Top

FusionProtFeatures for TP63_CYTH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TP63

Q9H3D4

CYTH3

O43739

Promotes guanine-nucleotide exchange on ARF1 and ARF6.Promotes the activation of ARF factors through replacement of GDPwith GTP. Play a role in the epithelial polarization (Bysimilarity). {ECO:0000250|UniProtKB:O08967,ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TP63_CYTH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TP63_CYTH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TP63HNRNPAB, GNB2L1, SCAF4, YAP1, HIPK2, BTRC, ADH5, AGBL2, ASPM, BRD8, NPRL3, TRAPPC11, CDT1, DAB2IP, DDX23, DNAJB6, DPH1, AGO1, AGO2, GAS8, IGF2BP1, LOC613037, JPH1, MTHFSD, MYL9, N4BP2, PIWIL1, RNF38, SMARCD2, TRMT11, EMX1, ITCH, MDM2, MDM4, WWP1, RELA, BRCA1, CHUK, IKBKB, FBXW7, CDKN2A, CDKN1A, TP53, RBL2, SFN, UBE2I, SUMO1, UBE4B, DAXX, PML, RCHY1, WWOX, FAS, CAD, FLNC, DHX9, SEC24C, VCP, SACS, PSMD2, HNRNPR, GOLGA4, HSPA5, FUS, A2M, SYNCRIP, ZNF676, TP63, CPSF6, PLS3, KRT5, CARM1, HNRNPL, CCT8, NONO, HNRNPK, KRT6C, TUBA1C, ATP5A1, RPL3, EEF1A1, RPSA, ZBTB4, HNRNPCL1, HNRNPA3, MAP1A, RPLP0, HIST1H1D, UACA, SNRPA, UPF2, CENPE, SAFB, S1PR5, RPL24, RPL13A, RPL12, MYLPF, HSP90AB1, ETV4, CEBPB, NFYA, NFKB1, STK11, NIPSNAP3A, ORM1, CCNC, ITIH4, BAG6, GCGR, HP, HPX, COPS6, SLC35A3, PINX1, SMAD3, RNF144B, EP300, KAT2B, CEP83, CHEK2, TP73, SH3KBP1, RPH3A, FOXK1, FOXK2, PEX14, ATF3CYTH3CNKSR1, CALCOCO1, IPCEF1, GNAQ, CCDC120, SYCE1, OIP5, WDR83, GPS2, CYTIP, FOSL2, PIK3CA, MTMR7, C1orf106, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TP63_CYTH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TP63_CYTH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTP63C1785148RAPP-HODGKIN SYNDROME6CTD_human;ORPHANET;UNIPROT
HgeneTP63C1858562ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 35CTD_human;UNIPROT
HgeneTP63C0406709Hay-Wells syndrome3CTD_human;UNIPROT
HgeneTP63C0024121Lung Neoplasms2CTD_human
HgeneTP63C1854442SPLIT-HAND/FOOT MALFORMATION 42CTD_human;UNIPROT
HgeneTP63C0001418Adenocarcinoma1CTD_human
HgeneTP63C0006145Breast Diseases1CTD_human
HgeneTP63C0007137Squamous cell carcinoma1CTD_human
HgeneTP63C0007621Neoplastic Cell Transformation1CTD_human
HgeneTP63C0008924Cleft Lip1CTD_human;HPO;ORPHANET
HgeneTP63C0008925Cleft Palate1CTD_human;HPO
HgeneTP63C0009404Colorectal Neoplasms1CTD_human
HgeneTP63C0016508Congenital Foot Deformity1CTD_human
HgeneTP63C0018566Congenital Hand Deformities1CTD_human
HgeneTP63C0027627Neoplasm Metastasis1CTD_human
HgeneTP63C0030297Pancreatic Neoplasm1CTD_human
HgeneTP63C0037268Skin Abnormalities1CTD_human
HgeneTP63C0038987Sweat Gland Neoplasms1CTD_human
HgeneTP63C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneTP63C0206720Squamous Cell Neoplasms1CTD_human
HgeneTP63C0206762Limb Deformities, Congenital1CTD_human
HgeneTP63C0376634Craniofacial Abnormalities1CTD_human
HgeneTP63C0406704Rudiger syndrome 11CTD_human;ORPHANET
HgeneTP63C0919267ovarian neoplasm1CTD_human
HgeneTP63C1720887Female Urogenital Diseases1CTD_human
HgeneTP63C1863204ADULT SYNDROME1CTD_human;ORPHANET;UNIPROT
HgeneTP63C1863753LIMB-MAMMARY SYNDROME1CTD_human;ORPHANET