|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 3917 |
FusionGeneSummary for BCAM_REG3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCAM_REG3A | Fusion gene ID: 3917 | Hgene | Tgene | Gene symbol | BCAM | REG3A | Gene ID | 4059 | 5068 |
| Gene name | basal cell adhesion molecule (Lutheran blood group) | regenerating family member 3 alpha | |
| Synonyms | AU|CD239|LU|MSK19 | HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3 | |
| Cytomap | 19q13.32 | 2p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | basal cell adhesion moleculeAuberger b antigenB-CAM cell surface glycoproteinB-cell adhesion moleculeF8/G253 antigenLutheran blood group variant LUGAbasal cell adhesion molecule (Lu and Au blood groups) | regenerating islet-derived protein 3-alphaPAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation- | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P50895 | Q06141 | |
| Ensembl transtripts involved in fusion gene | ENST00000589651, ENST00000270233, | ENST00000409839, ENST00000393878, ENST00000305165, | |
| Fusion gene scores | * DoF score | 9 X 9 X 4=324 | 4 X 4 X 2=32 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BCAM [Title/Abstract] AND REG3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-XR-A8TE-01A | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000589651 | ENST00000409839 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| intron-3CDS | ENST00000589651 | ENST00000393878 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| intron-3CDS | ENST00000589651 | ENST00000305165 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| 3UTR-3CDS | ENST00000270233 | ENST00000409839 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| 3UTR-3CDS | ENST00000270233 | ENST00000393878 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
| 3UTR-3CDS | ENST00000270233 | ENST00000305165 | BCAM | chr19 | 45324304 | + | REG3A | chr2 | 79385877 | - |
Top |
FusionProtFeatures for BCAM_REG3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCAM | REG3A |
| Laminin alpha-5 receptor. May mediate intracellularsignaling. {ECO:0000269|PubMed:9616226}. | Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Regulates keratinocyte proliferation and differentiation afterskin injury via activation of EXTL3-PI3K-AKT signaling pathway.{ECO:0000269|PubMed:16931762}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for BCAM_REG3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for BCAM_REG3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BCAM | LAMA5, UBE2I, KLHL2, LAMA4, ZSWIM2, ARNTL, EPHA7, ATP6V0A1, TMEM11, CDH8, PRCC, ATP6V0A2, ST8SIA4, ATP11C, TNPO2, MTCH2, TNPO3, LAMB1, CD79A | REG3A | SDC2, FN1, MDFI, ACTB, ACTA2, ACTBL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for BCAM_REG3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BCAM_REG3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|