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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39168

FusionGeneSummary for TP53_OSBPL10

check button Fusion gene summary
Fusion gene informationFusion gene name: TP53_OSBPL10
Fusion gene ID: 39168
HgeneTgene
Gene symbol

TP53

OSBPL10

Gene ID

7158

114884

Gene nametumor protein p53 binding protein 1oxysterol binding protein like 10
Synonyms53BP1|TDRD30|TP53|p202|p53BP1ORP10|OSBP9
Cytomap

15q15.3

3p23

Type of geneprotein-codingprotein-coding
DescriptionTP53-binding protein 1p53-binding protein 1tumor protein 53-binding protein, 1tumor suppressor p53-binding protein 1oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10
Modification date2018052720180523
UniProtAcc

P04637

Q9BXB5

Ensembl transtripts involved in fusion geneENST00000413465, ENST00000359597, 
ENST00000269305, ENST00000455263, 
ENST00000420246, ENST00000445888, 
ENST00000574684, 		ENST00000396556, 
ENST00000438237, ENST00000467647, 
Fusion gene scores* DoF score22 X 7 X 7=10786 X 3 X 4=72
# samples 215
** MAII scorelog2(21/1078*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TP53 [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP53

GO:0006303

double-strand break repair via nonhomologous end joining

23333306|23760478|28241136

HgeneTP53

GO:0006974

cellular response to DNA damage stimulus

17500065|28241136

HgeneTP53

GO:0045830

positive regulation of isotype switching

23345425

HgeneTP53

GO:0051260

protein homooligomerization

23345425

HgeneTP53

GO:2000042

negative regulation of double-strand break repair via homologous recombination

23333306|23345425


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA947588TP53chr17

7573268

+OSBPL10chr3

31964262

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000413465ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000413465ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000413465ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000359597ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000359597ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000359597ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000269305ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000269305ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000269305ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000455263ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000455263ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000455263ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000420246ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000420246ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000420246ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000445888ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000445888ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000445888ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000574684ENST00000396556TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000574684ENST00000438237TP53chr17

7573268

+OSBPL10chr3

31964262

+
intron-intronENST00000574684ENST00000467647TP53chr17

7573268

+OSBPL10chr3

31964262

+

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FusionProtFeatures for TP53_OSBPL10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TP53

P04637

OSBPL10

Q9BXB5

Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TP53_OSBPL10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TP53_OSBPL10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TP53_OSBPL10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTP53P04637DB01593ZincCellular tumor antigen p53small moleculeapproved|investigational
HgeneTP53P04637DB00945Acetylsalicylic acidCellular tumor antigen p53small moleculeapproved|vet_approved

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RelatedDiseases for TP53_OSBPL10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTP53C1835398LI-FRAUMENI SYNDROME 119CTD_human;UNIPROT
HgeneTP53C0009404Colorectal Neoplasms8CTD_human
HgeneTP53C0033578Prostatic Neoplasms6CTD_human;HPO
HgeneTP53C2239176Liver carcinoma6CTD_human;HPO
HgeneTP53C0024121Lung Neoplasms5CTD_human
HgeneTP53C1458155Mammary Neoplasms5CTD_human
HgeneTP53C0005695Bladder Neoplasm4CTD_human
HgeneTP53C0007134Renal Cell Carcinoma4CTD_human;HPO
HgeneTP53C0001418Adenocarcinoma3CTD_human
HgeneTP53C0007117Basal cell carcinoma3CTD_human
HgeneTP53C0007131Non-Small Cell Lung Carcinoma3CTD_human
HgeneTP53C0009375Colonic Neoplasms3CTD_human;HPO
HgeneTP53C0017638Glioma3CTD_human
HgeneTP53C0025202melanoma3CTD_human
HgeneTP53C0206686Adrenocortical carcinoma3CTD_human;HPO;ORPHANET
HgeneTP53C0001969Alcoholic Intoxication2PSYGENET
HgeneTP53C0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneTP53C0007137Squamous cell carcinoma2CTD_human
HgeneTP53C0014859Esophageal Neoplasms2CTD_human
HgeneTP53C0016978gallbladder neoplasm2CTD_human
HgeneTP53C0023903Liver neoplasms2CTD_human
HgeneTP53C0036920Sezary Syndrome2CTD_human
HgeneTP53C0038356Stomach Neoplasms2CTD_human;HPO
HgeneTP53C0149925Small cell carcinoma of lung2CTD_human;ORPHANET
HgeneTP53C0311375Arsenic Poisoning2CTD_human
HgeneTP53C0001430Adenoma1CTD_human
HgeneTP53C0001624Adrenal Gland Neoplasms1CTD_human
HgeneTP53C0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneTP53C0004698Balkan Nephropathy1CTD_human
HgeneTP53C0007138Carcinoma, Transitional Cell1CTD_human
HgeneTP53C0007194Hypertrophic Cardiomyopathy1CTD_human
HgeneTP53C0007273Carotid Artery Diseases1CTD_human
HgeneTP53C0007621Neoplastic Cell Transformation1CTD_human
HgeneTP53C0007786Brain Ischemia1CTD_human
HgeneTP53C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneTP53C0011303Demyelinating Diseases1CTD_human
HgeneTP53C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneTP53C0013990Pathological accumulation of air in tissues1CTD_human
HgeneTP53C0018923Hemangiosarcoma1CTD_human
HgeneTP53C0020538Hypertensive disease1CTD_human
HgeneTP53C0021361Female infertility1CTD_human
HgeneTP53C0021364Male infertility1CTD_human
HgeneTP53C0022116Ischemia1CTD_human
HgeneTP53C0022593Keratosis1CTD_human
HgeneTP53C0022783Vulvar Lichen Sclerosus1CTD_human
HgeneTP53C0023434Chronic Lymphocytic Leukemia1CTD_human;ORPHANET
HgeneTP53C0023897Liver Diseases, Parasitic1CTD_human
HgeneTP53C0023904Liver Neoplasms, Experimental1CTD_human
HgeneTP53C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneTP53C0024809Marijuana Abuse1PSYGENET
HgeneTP53C0026640Mouth Neoplasms1CTD_human
HgeneTP53C0027627Neoplasm Metastasis1CTD_human
HgeneTP53C0029463Osteosarcoma1CTD_human;HPO
HgeneTP53C0030849Penile Neoplasms1CTD_human
HgeneTP53C0032578Polyploidy1CTD_human
HgeneTP53C0033860Psoriasis1CTD_human
HgeneTP53C0036341Schizophrenia1CTD_human
HgeneTP53C0037286Skin Neoplasms1CTD_human;HPO
HgeneTP53C0040100Thymoma1CTD_human
HgeneTP53C0040136Thyroid Neoplasm1CTD_human
HgeneTP53C0042065Genitourinary Neoplasms1CTD_human
HgeneTP53C0042076Urologic Neoplasms1CTD_human
HgeneTP53C0079772T-Cell Lymphoma1CTD_human
HgeneTP53C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneTP53C0085136Central Nervous System Neoplasms1CTD_human
HgeneTP53C0085390Li-Fraumeni Syndrome1CTD_human;ORPHANET
HgeneTP53C0206681Adenocarcinoma, Clear Cell1CTD_human
HgeneTP53C0206698Cholangiocarcinoma1CTD_human
HgeneTP53C0262584Carcinoma, Small Cell1CTD_human
HgeneTP53C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneTP53C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneTP53C0345967Malignant mesothelioma1CTD_human
HgeneTP53C0677886Epithelial ovarian cancer1CTD_human
HgeneTP53C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneTP53C1261473Sarcoma1CTD_human;HPO
HgeneTP53C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
HgeneTP53C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneTP53C2609414Acute kidney injury1CTD_human
HgeneTP53C2931713Chromosome 17 deletion1CTD_human
HgeneTP53C2931822Nasopharyngeal carcinoma1CTD_human