![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 39168 |
FusionGeneSummary for TP53_OSBPL10 |
![]() |
Fusion gene information | Fusion gene name: TP53_OSBPL10 | Fusion gene ID: 39168 | Hgene | Tgene | Gene symbol | TP53 | OSBPL10 | Gene ID | 7158 | 114884 |
Gene name | tumor protein p53 binding protein 1 | oxysterol binding protein like 10 | |
Synonyms | 53BP1|TDRD30|TP53|p202|p53BP1 | ORP10|OSBP9 | |
Cytomap | 15q15.3 | 3p23 | |
Type of gene | protein-coding | protein-coding | |
Description | TP53-binding protein 1p53-binding protein 1tumor protein 53-binding protein, 1tumor suppressor p53-binding protein 1 | oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P04637 | Q9BXB5 | |
Ensembl transtripts involved in fusion gene | ENST00000413465, ENST00000359597, ENST00000269305, ENST00000455263, ENST00000420246, ENST00000445888, ENST00000574684, | ENST00000396556, ENST00000438237, ENST00000467647, | |
Fusion gene scores | * DoF score | 22 X 7 X 7=1078 | 6 X 3 X 4=72 |
# samples | 21 | 5 | |
** MAII score | log2(21/1078*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TP53 [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TP53 | GO:0006303 | double-strand break repair via nonhomologous end joining | 23333306|23760478|28241136 |
Hgene | TP53 | GO:0006974 | cellular response to DNA damage stimulus | 17500065|28241136 |
Hgene | TP53 | GO:0045830 | positive regulation of isotype switching | 23345425 |
Hgene | TP53 | GO:0051260 | protein homooligomerization | 23345425 |
Hgene | TP53 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 23333306|23345425 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA947588 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000413465 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000413465 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000413465 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000359597 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000359597 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000359597 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000269305 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000269305 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000269305 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000455263 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000455263 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000455263 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000420246 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000420246 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000420246 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000445888 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000445888 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000445888 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000574684 | ENST00000396556 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000574684 | ENST00000438237 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
intron-intron | ENST00000574684 | ENST00000467647 | TP53 | chr17 | 7573268 | + | OSBPL10 | chr3 | 31964262 | + |
Top |
FusionProtFeatures for TP53_OSBPL10 |
![]() |
Hgene | Tgene |
TP53 | OSBPL10 |
Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TP53_OSBPL10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TP53_OSBPL10 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TP53_OSBPL10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TP53 | P04637 | DB01593 | Zinc | Cellular tumor antigen p53 | small molecule | approved|investigational |
Hgene | TP53 | P04637 | DB00945 | Acetylsalicylic acid | Cellular tumor antigen p53 | small molecule | approved|vet_approved |
Top |
RelatedDiseases for TP53_OSBPL10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TP53 | C1835398 | LI-FRAUMENI SYNDROME 1 | 19 | CTD_human;UNIPROT |
Hgene | TP53 | C0009404 | Colorectal Neoplasms | 8 | CTD_human |
Hgene | TP53 | C0033578 | Prostatic Neoplasms | 6 | CTD_human;HPO |
Hgene | TP53 | C2239176 | Liver carcinoma | 6 | CTD_human;HPO |
Hgene | TP53 | C0024121 | Lung Neoplasms | 5 | CTD_human |
Hgene | TP53 | C1458155 | Mammary Neoplasms | 5 | CTD_human |
Hgene | TP53 | C0005695 | Bladder Neoplasm | 4 | CTD_human |
Hgene | TP53 | C0007134 | Renal Cell Carcinoma | 4 | CTD_human;HPO |
Hgene | TP53 | C0001418 | Adenocarcinoma | 3 | CTD_human |
Hgene | TP53 | C0007117 | Basal cell carcinoma | 3 | CTD_human |
Hgene | TP53 | C0007131 | Non-Small Cell Lung Carcinoma | 3 | CTD_human |
Hgene | TP53 | C0009375 | Colonic Neoplasms | 3 | CTD_human;HPO |
Hgene | TP53 | C0017638 | Glioma | 3 | CTD_human |
Hgene | TP53 | C0025202 | melanoma | 3 | CTD_human |
Hgene | TP53 | C0206686 | Adrenocortical carcinoma | 3 | CTD_human;HPO;ORPHANET |
Hgene | TP53 | C0001969 | Alcoholic Intoxication | 2 | PSYGENET |
Hgene | TP53 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | TP53 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
Hgene | TP53 | C0014859 | Esophageal Neoplasms | 2 | CTD_human |
Hgene | TP53 | C0016978 | gallbladder neoplasm | 2 | CTD_human |
Hgene | TP53 | C0023903 | Liver neoplasms | 2 | CTD_human |
Hgene | TP53 | C0036920 | Sezary Syndrome | 2 | CTD_human |
Hgene | TP53 | C0038356 | Stomach Neoplasms | 2 | CTD_human;HPO |
Hgene | TP53 | C0149925 | Small cell carcinoma of lung | 2 | CTD_human;ORPHANET |
Hgene | TP53 | C0311375 | Arsenic Poisoning | 2 | CTD_human |
Hgene | TP53 | C0001430 | Adenoma | 1 | CTD_human |
Hgene | TP53 | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Hgene | TP53 | C0004698 | Balkan Nephropathy | 1 | CTD_human |
Hgene | TP53 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | TP53 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
Hgene | TP53 | C0007273 | Carotid Artery Diseases | 1 | CTD_human |
Hgene | TP53 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | TP53 | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | TP53 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | TP53 | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Hgene | TP53 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | TP53 | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
Hgene | TP53 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Hgene | TP53 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | TP53 | C0021361 | Female infertility | 1 | CTD_human |
Hgene | TP53 | C0021364 | Male infertility | 1 | CTD_human |
Hgene | TP53 | C0022116 | Ischemia | 1 | CTD_human |
Hgene | TP53 | C0022593 | Keratosis | 1 | CTD_human |
Hgene | TP53 | C0022783 | Vulvar Lichen Sclerosus | 1 | CTD_human |
Hgene | TP53 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human;ORPHANET |
Hgene | TP53 | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human |
Hgene | TP53 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | TP53 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Hgene | TP53 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
Hgene | TP53 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | TP53 | C0029463 | Osteosarcoma | 1 | CTD_human;HPO |
Hgene | TP53 | C0030849 | Penile Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0032578 | Polyploidy | 1 | CTD_human |
Hgene | TP53 | C0033860 | Psoriasis | 1 | CTD_human |
Hgene | TP53 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | TP53 | C0037286 | Skin Neoplasms | 1 | CTD_human;HPO |
Hgene | TP53 | C0040100 | Thymoma | 1 | CTD_human |
Hgene | TP53 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Hgene | TP53 | C0042065 | Genitourinary Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0042076 | Urologic Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Hgene | TP53 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Hgene | TP53 | C0085136 | Central Nervous System Neoplasms | 1 | CTD_human |
Hgene | TP53 | C0085390 | Li-Fraumeni Syndrome | 1 | CTD_human;ORPHANET |
Hgene | TP53 | C0206681 | Adenocarcinoma, Clear Cell | 1 | CTD_human |
Hgene | TP53 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | TP53 | C0262584 | Carcinoma, Small Cell | 1 | CTD_human |
Hgene | TP53 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | TP53 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Hgene | TP53 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | TP53 | C0677886 | Epithelial ovarian cancer | 1 | CTD_human |
Hgene | TP53 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Hgene | TP53 | C1261473 | Sarcoma | 1 | CTD_human;HPO |
Hgene | TP53 | C1860789 | Leukemia, Megakaryoblastic, of Down Syndrome | 1 | CTD_human |
Hgene | TP53 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Hgene | TP53 | C2609414 | Acute kidney injury | 1 | CTD_human |
Hgene | TP53 | C2931713 | Chromosome 17 deletion | 1 | CTD_human |
Hgene | TP53 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |