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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39123

FusionGeneSummary for TOX3_ITFG1

check button Fusion gene summary
Fusion gene informationFusion gene name: TOX3_ITFG1
Fusion gene ID: 39123
HgeneTgene
Gene symbol

TOX3

ITFG1

Gene ID

27324

81533

Gene nameTOX high mobility group box family member 3integrin alpha FG-GAP repeat containing 1
SynonymsCAGF9|TNRC92310047C21Rik|CDA08|LNKN-1|TIP
Cytomap

16q12.1

16q12.1

Type of geneprotein-codingprotein-coding
DescriptionTOX high mobility group box family member 3CAG trinucleotide repeat-containing gene F9 proteintrinucleotide repeat-containing gene 9 proteinT-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1
Modification date2018052220180519
UniProtAcc

O15405

Q8TB96

Ensembl transtripts involved in fusion geneENST00000407228, ENST00000219746, 
ENST00000568047, ENST00000320640, 
ENST00000544001, 
Fusion gene scores* DoF score7 X 5 X 4=1406 X 3 X 5=90
# samples 85
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOX3 [Title/Abstract] AND ITFG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOX3

GO:0042981

regulation of apoptotic process

21172805

HgeneTOX3

GO:0043524

negative regulation of neuron apoptotic process

21172805

HgeneTOX3

GO:0045893

positive regulation of transcription, DNA-templated

21172805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24K-01ATOX3chr16

52479906

-ITFG1chr16

47196575

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000407228ENST00000568047TOX3chr16

52479906

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000407228ENST00000320640TOX3chr16

52479906

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000407228ENST00000544001TOX3chr16

52479906

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000219746ENST00000568047TOX3chr16

52479906

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000219746ENST00000320640TOX3chr16

52479906

-ITFG1chr16

47196575

-
5CDS-5UTRENST00000219746ENST00000544001TOX3chr16

52479906

-ITFG1chr16

47196575

-

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FusionProtFeatures for TOX3_ITFG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOX3

O15405

ITFG1

Q8TB96

Transcriptional coactivator of the p300/CBP-mediatedtranscription complex. Activates transactivation through cAMPresponse element (CRE) sites. Protects against cell death byinducing antiapoptotic and repressing pro-apoptotic transcripts.Stimulates transcription from the estrogen-responsive or BCL-2promoters. Required for depolarization-induced transcriptionactivation of the C-FOS promoter in neurons. Associates withchromatin to the estrogen-responsive C3 promoter region.{ECO:0000269|PubMed:21172805}. Modulator of T-cell function. Has a protective effect ingraft versus host disease model (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TOX3_ITFG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TOX3_ITFG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOX3ODF2, TMEM67ITFG1HMOX2, MRPL44, CDC73, SERBP1, TAF1D, NUDT3, FAM118B, TNFRSF14, FBXO6, HLA-DPA1, CD1B, CEACAM21, HLA-C, PCDHGB1, TMEM30B, CDH5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TOX3_ITFG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TOX3_ITFG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTOX3C0242788Breast Neoplasms, Male1CTD_human
HgeneTOX3C1458155Mammary Neoplasms1CTD_human