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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39054

FusionGeneSummary for TOM1L2_SREBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TOM1L2_SREBF1
Fusion gene ID: 39054
HgeneTgene
Gene symbol

TOM1L2

SREBF1

Gene ID

146691

6720

Gene nametarget of myb1 like 2 membrane trafficking proteinsterol regulatory element binding transcription factor 1
Synonyms-SREBP1|bHLHd1
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
DescriptionTOM1-like protein 2target of Myb-like protein 2target of myb1-like 2sterol regulatory element-binding protein 1class D basic helix-loop-helix protein 1
Modification date2018051920180522
UniProtAcc

Q6ZVM7

P36956

Ensembl transtripts involved in fusion geneENST00000581396, ENST00000379504, 
ENST00000318094, ENST00000395739, 
ENST00000535933, ENST00000540946, 
ENST00000542206, ENST00000478943, 
ENST00000577517, 
ENST00000338854, 
ENST00000395757, ENST00000355815, 
ENST00000261646, ENST00000435530, 
ENST00000583732, 
Fusion gene scores* DoF score8 X 7 X 6=3365 X 4 X 4=80
# samples 95
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOM1L2 [Title/Abstract] AND SREBF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOM1L2

GO:0007165

signal transduction

16479011

HgeneTOM1L2

GO:0045839

negative regulation of mitotic nuclear division

16479011

TgeneSREBF1

GO:0045944

positive regulation of transcription by RNA polymerase II

26437365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A3IK-01ATOM1L2chr17

17875576

-SREBF1chr17

17723835

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000581396ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000581396ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000581396ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000581396ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000581396ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000581396ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000379504ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000379504ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000379504ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000379504ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000379504ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000379504ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000318094ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000318094ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000318094ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000318094ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000318094ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000318094ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000395739ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000395739ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000395739ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000395739ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000395739ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000395739ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000535933ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000535933ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000535933ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000535933ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000535933ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000535933ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000540946ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000540946ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000540946ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000540946ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000540946ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000540946ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
Frame-shitENST00000542206ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000542206ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000542206ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000542206ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-intronENST00000542206ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
5CDS-5UTRENST00000542206ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-3CDSENST00000478943ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000478943ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000478943ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000478943ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000478943ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-5UTRENST00000478943ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-3CDSENST00000577517ENST00000338854TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000577517ENST00000395757TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000577517ENST00000355815TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000577517ENST00000261646TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-intronENST00000577517ENST00000435530TOM1L2chr17

17875576

-SREBF1chr17

17723835

-
intron-5UTRENST00000577517ENST00000583732TOM1L2chr17

17875576

-SREBF1chr17

17723835

-

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FusionProtFeatures for TOM1L2_SREBF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOM1L2

Q6ZVM7

SREBF1

P36956

Probable role in protein transport. May regulate growthfactor-induced mitogenic signaling. {ECO:0000269|PubMed:16412388,ECO:0000269|PubMed:16479011}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TOM1L2_SREBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TOM1L2_SREBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOM1L2TOLLIP, NEDD4, CLTC, APP, AHCYL1, LAGE3, IGBP1, SULT1A1, RCN1, SIN3A, S100A4, DSTN, DFFA, UBA2, S100A6, SRXN1, SERPINH1, UBC, LAPTM5, RNF11, MYO6, BAG3, MAP3K1, AGL, XPO1, SMURF1, CUEDC1, SZRD1, NDUFA6, WBP2SREBF1LMNA, TWIST2, UBE2I, CREBBP, YY1, SP1, NR0B1, MAPK3, MAPK1, FBXW7, KLF13, EP300, AR, MED15, MED23, MED7, MED13, MED12, MED1, MED14, MED24, MED26, MED6, HNF4A, TRRAP, KAT2A, ATM, GCN1L1, TADA2B, TADA3, RUVBL2, SIRT1, MED25, MED17, MED21, CDK8, USF1, GSK3B, ZBTB7C, SREBF2, SREBF1, ZBTB7A, SCAP, INSIG1, INSIG2, EGF, ATXN1, ATXN1L, HSP90AA1, SMARCD3, ERLIN2, KLF5, ID2, ID3, PRMT5, PVALB, SORL1, MTNR1B, PLK1, TRIM25, POLR2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TOM1L2_SREBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TOM1L2_SREBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSREBF1C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneSREBF1C0400966Non-alcoholic Fatty Liver Disease2CTD_human
TgeneSREBF1C2239176Liver carcinoma2CTD_human
TgeneSREBF1C0015695Fatty Liver1CTD_human
TgeneSREBF1C0021655Insulin Resistance1CTD_human
TgeneSREBF1C0022661Kidney Failure, Chronic1CTD_human
TgeneSREBF1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSREBF1C0028754Obesity1CTD_human
TgeneSREBF1C0036341Schizophrenia1PSYGENET