FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39048

FusionGeneSummary for TOM1L2_ANK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TOM1L2_ANK3
Fusion gene ID: 39048
HgeneTgene
Gene symbol

TOM1L2

ANK3

Gene ID

146691

288

Gene nametarget of myb1 like 2 membrane trafficking proteinankyrin 3
Synonyms-ANKYRIN-G|MRT37
Cytomap

17p11.2

10q21.2

Type of geneprotein-codingprotein-coding
DescriptionTOM1-like protein 2target of Myb-like protein 2target of myb1-like 2ankyrin-3ankyrin 3, node of Ranvier (ankyrin G)
Modification date2018051920180523
UniProtAcc

Q6ZVM7

Q12955

Ensembl transtripts involved in fusion geneENST00000581396, ENST00000379504, 
ENST00000318094, ENST00000395739, 
ENST00000535933, ENST00000540946, 
ENST00000542206, ENST00000478943, 
ENST00000577517, 
ENST00000280772, 
ENST00000373827, ENST00000355288, 
ENST00000503366, ENST00000510382, 
ENST00000460468, 
Fusion gene scores* DoF score8 X 7 X 6=33612 X 16 X 9=1728
# samples 918
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1728*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOM1L2 [Title/Abstract] AND ANK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOM1L2

GO:0007165

signal transduction

16479011

HgeneTOM1L2

GO:0045839

negative regulation of mitotic nuclear division

16479011


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1OZ-01ATOM1L2chr17

17875576

-ANK3chr10

62268383

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000581396ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000581396ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000581396ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000581396ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000581396ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000581396ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000379504ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000379504ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000379504ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000379504ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000379504ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000379504ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000318094ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000318094ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000318094ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000318094ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000318094ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000318094ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000395739ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000395739ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000395739ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000395739ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000395739ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000395739ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000535933ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000535933ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000535933ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000535933ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000535933ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000535933ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000540946ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000540946ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000540946ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000540946ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000540946ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000540946ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000542206ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000542206ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000542206ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000542206ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-5UTRENST00000542206ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
5CDS-intronENST00000542206ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000478943ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000478943ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000478943ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000478943ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-5UTRENST00000478943ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000478943ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000577517ENST00000280772TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000577517ENST00000373827TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000577517ENST00000355288TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000577517ENST00000503366TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-5UTRENST00000577517ENST00000510382TOM1L2chr17

17875576

-ANK3chr10

62268383

-
intron-intronENST00000577517ENST00000460468TOM1L2chr17

17875576

-ANK3chr10

62268383

-

Top

FusionProtFeatures for TOM1L2_ANK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOM1L2

Q6ZVM7

ANK3

Q12955

Probable role in protein transport. May regulate growthfactor-induced mitogenic signaling. {ECO:0000269|PubMed:16412388,ECO:0000269|PubMed:16479011}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TOM1L2_ANK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TOM1L2_ANK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TOM1L2TOLLIP, NEDD4, CLTC, APP, AHCYL1, LAGE3, IGBP1, SULT1A1, RCN1, SIN3A, S100A4, DSTN, DFFA, UBA2, S100A6, SRXN1, SERPINH1, UBC, LAPTM5, RNF11, MYO6, BAG3, MAP3K1, AGL, XPO1, SMURF1, CUEDC1, SZRD1, NDUFA6, WBP2ANK3KCNC1, SPTBN4, TIAM1, MAPK6, SMAD3, SMAD2, RNF2, DOK4, PALM2, C16orf70, SCN1B, SRPK2, TMEM17, KIF11, PCNA, MCM2, CDH1, CTDSPL, RAPGEF5, CHL1, MAPK8IP1, FEZ1, HIF1AN, UXS1, PWP1, NEXN, LILRB3, PROSER2, ARHGAP22, USP15, SPAG9, MCM4, MCM6, EPS15L1, IVNS1ABP, GTF3C4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TOM1L2_ANK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TOM1L2_ANK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANK3C0005586Bipolar Disorder7CTD_human;PSYGENET
TgeneANK3C0036341Schizophrenia3PSYGENET
TgeneANK3C0033975Psychotic Disorders2PSYGENET
TgeneANK3C0525045Mood Disorders2PSYGENET
TgeneANK3C0033300Progeria1CTD_human
TgeneANK3C0038220Status Epilepticus1CTD_human
TgeneANK3C0178417Anhedonia1PSYGENET
TgeneANK3C0349204Nonorganic psychosis1PSYGENET