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Fusion gene ID: 39025 |
FusionGeneSummary for TNS3_ZNRF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNS3_ZNRF2 | Fusion gene ID: 39025 | Hgene | Tgene | Gene symbol | TNS3 | ZNRF2 | Gene ID | 64759 | 223082 |
| Gene name | tensin 3 | zinc and ring finger 2 | |
| Synonyms | TEM6|TENS1 | RNF202 | |
| Cytomap | 7p12.3 | 7p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6 | E3 ubiquitin-protein ligase ZNRF2RING finger protein 202RING-type E3 ubiquitin transferase ZNRF2protein Ells2zinc and ring finger 2, E3 ubiquitin protein ligasezinc finger/RING finger 2zinc/RING finger protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q68CZ2 | Q8NHG8 | |
| Ensembl transtripts involved in fusion gene | ENST00000311160, ENST00000355730, ENST00000398879, ENST00000442536, ENST00000458317, ENST00000474346, | ENST00000323037, ENST00000459998, | |
| Fusion gene scores | * DoF score | 15 X 13 X 9=1755 | 4 X 4 X 3=48 |
| # samples | 17 | 4 | |
| ** MAII score | log2(17/1755*10)=-3.36786437905422 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNS3 [Title/Abstract] AND ZNRF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AQ-A04L-01B | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000311160 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| 5CDS-intron | ENST00000311160 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| In-frame | ENST00000355730 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| 5CDS-intron | ENST00000355730 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| In-frame | ENST00000398879 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| 5CDS-intron | ENST00000398879 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| In-frame | ENST00000442536 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| 5CDS-intron | ENST00000442536 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| In-frame | ENST00000458317 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| 5CDS-intron | ENST00000458317 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| intron-3CDS | ENST00000474346 | ENST00000323037 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
| intron-intron | ENST00000474346 | ENST00000459998 | TNS3 | chr7 | 47474880 | - | ZNRF2 | chr7 | 30401993 | + |
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FusionProtFeatures for TNS3_ZNRF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNS3 | ZNRF2 |
| May play a role in actin remodeling. Involved in thedissociation of the integrin-tensin-actin complex. EGF activatesTNS4 and down-regulates TNS3 which results in capping the tail ofITGB1. Seems to be involved in mammary cell migration. May beinvolved in cell migration and bone development (By similarity).{ECO:0000250, ECO:0000269|PubMed:17643115}. | May play a role in the establishment and maintenance ofneuronal transmission and plasticity via its ubiquitin ligaseactivity. E3 ubiquitin ligases accept ubiquitin from an E2ubiquitin-conjugating enzyme in the form of a thioester and thendirectly transfer the ubiquitin to targeted substrates.{ECO:0000269|PubMed:14561866}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000311160 | - | 8 | 31 | 941_944 | 108 | 1446 | Compositional bias | Note=Poly-Ser |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000398879 | - | 8 | 31 | 941_944 | 108 | 1446 | Compositional bias | Note=Poly-Ser |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000442536 | - | 8 | 15 | 941_944 | 108 | 204 | Compositional bias | Note=Poly-Ser |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000458317 | - | 8 | 14 | 941_944 | 108 | 251 | Compositional bias | Note=Poly-Ser |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000311160 | - | 8 | 31 | 1172_1282 | 108 | 1446 | Domain | SH2 |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000311160 | - | 8 | 31 | 175_301 | 108 | 1446 | Domain | C2 tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000311160 | - | 8 | 31 | 1_170 | 108 | 1446 | Domain | Phosphatase tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000398879 | - | 8 | 31 | 1172_1282 | 108 | 1446 | Domain | SH2 |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000398879 | - | 8 | 31 | 175_301 | 108 | 1446 | Domain | C2 tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000398879 | - | 8 | 31 | 1_170 | 108 | 1446 | Domain | Phosphatase tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000442536 | - | 8 | 15 | 1172_1282 | 108 | 204 | Domain | SH2 |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000442536 | - | 8 | 15 | 175_301 | 108 | 204 | Domain | C2 tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000442536 | - | 8 | 15 | 1_170 | 108 | 204 | Domain | Phosphatase tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000458317 | - | 8 | 14 | 1172_1282 | 108 | 251 | Domain | SH2 |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000458317 | - | 8 | 14 | 175_301 | 108 | 251 | Domain | C2 tensin-type |
| Hgene | >TNS3 | chr7:47474880 | chr7:30401993 | ENST00000458317 | - | 8 | 14 | 1_170 | 108 | 251 | Domain | Phosphatase tensin-type |
| Tgene | ZNRF2 | chr7:47474880 | chr7:30401993 | ENST00000323037 | + | 2 | 5 | 124_127 | 223 | 289 | Compositional bias | Note=Poly-Gly |
| Tgene | ZNRF2 | chr7:47474880 | chr7:30401993 | ENST00000323037 | + | 2 | 5 | 36_40 | 223 | 289 | Compositional bias | Note=Poly-Gly |
| Tgene | ZNRF2 | chr7:47474880 | chr7:30401993 | ENST00000323037 | + | 2 | 5 | 41_97 | 223 | 289 | Compositional bias | Note=Ala-rich |
| Tgene | ZNRF2 | chr7:47474880 | chr7:30401993 | ENST00000323037 | + | 2 | 5 | 199_240 | 223 | 289 | Zinc finger | RING-type%3B atypical |
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FusionGeneSequence for TNS3_ZNRF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TNS3_ENST00000311160_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_127aa MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKA >In-frame_TNS3_ENST00000355730_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_127aa MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKA >In-frame_TNS3_ENST00000398879_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_127aa MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKA >In-frame_TNS3_ENST00000442536_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_127aa MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKA >In-frame_TNS3_ENST00000458317_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_127aa MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TNS3_ENST00000311160_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_382nt ATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTAC CTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGAC CTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCG CAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTG >In-frame_TNS3_ENST00000355730_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_382nt ATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTAC CTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGAC CTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCG CAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTG >In-frame_TNS3_ENST00000398879_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_382nt ATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTAC CTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGAC CTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCG CAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTG >In-frame_TNS3_ENST00000442536_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_382nt ATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTAC CTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGAC CTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCG CAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTG >In-frame_TNS3_ENST00000458317_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_382nt ATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTAC CTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGAC CTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCG CAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TNS3_ENST00000311160_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_2420nt AGCCAGCCAGGAGGACGGGCCCGCCCGCGCGCTACTCGGAGCCCAGCCTCGTTGCGGCCATCGCCCTGCCGGACCGCGCCTCAGGCTCCC CCAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAAACAAATTAT TGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGGTGTGCAAGT CCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAGTCCCACCAT GGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTACCT GCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGACCT TACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCGCA GGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCC CTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAA TCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACT GGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAA ATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGA TTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCA ACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAA ACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGA CTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATA ATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAAT CAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGG GTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAG GCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAAT TTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTA GATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAG AAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTA CAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGG TGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAAT TTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCA >In-frame_TNS3_ENST00000355730_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_2429nt AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT >In-frame_TNS3_ENST00000398879_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_2429nt AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT >In-frame_TNS3_ENST00000442536_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_2429nt AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT >In-frame_TNS3_ENST00000458317_chr7_47474880_-_ZNRF2_ENST00000323037_chr7_30401993_+_2429nt AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT |
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FusionGenePPI for TNS3_ZNRF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TNS3 | MAT2B, APOA1, ERBB2, ERBB3, PTPN12, DNPEP, GANAB, TRIM47, ENO1, MOV10, NXF1, EGFR, SRPK2, XPO1, CTNNAL1, DMD, DTNB, PYCR2, SNTB1, SNTB2, UTRN, EPHA4, TRIM25 | ZNRF2 | UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2N, ELAVL1, YWHAQ, ATP1A2, ZNRF1, UBE2E1, CCDC8, ATP1A1, UBC, XPO1, MTOR, RPTOR, MLST8, PPP6C, ANKRD28, PPP6R3, ATP6V0A2, LAMTOR1, WDR5B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNS3_ZNRF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNS3_ZNRF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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