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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39014

FusionGeneSummary for TNS3_ELMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNS3_ELMO1
Fusion gene ID: 39014
HgeneTgene
Gene symbol

TNS3

ELMO1

Gene ID

64759

9844

Gene nametensin 3engulfment and cell motility 1
SynonymsTEM6|TENS1CED-12|CED12|ELMO-1
Cytomap

7p12.3

7p14.2-p14.1

Type of geneprotein-codingprotein-coding
Descriptiontensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6engulfment and cell motility protein 1ced-12 homolog 1
Modification date2018051920180519
UniProtAcc

Q68CZ2

Q92556

Ensembl transtripts involved in fusion geneENST00000311160, ENST00000355730, 
ENST00000398879, ENST00000442536, 
ENST00000458317, ENST00000474346, 
ENST00000341056, ENST00000396045, 
ENST00000310758, ENST00000396040, 
ENST00000442504, ENST00000448602, 
ENST00000479447, 
Fusion gene scores* DoF score15 X 13 X 9=175510 X 7 X 7=490
# samples 1712
** MAII scorelog2(17/1755*10)=-3.36786437905422
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/490*10)=-2.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNS3 [Title/Abstract] AND ELMO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-8615-01ATNS3chr7

47451325

-ELMO1chr7

36934622

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311160ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000311160ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000311160ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000311160ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000311160ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000311160ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-intronENST00000311160ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-
Frame-shiftENST00000355730ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000355730ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000355730ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000355730ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000355730ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000355730ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-intronENST00000355730ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-
Frame-shiftENST00000398879ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000398879ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000398879ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000398879ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000398879ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000398879ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-intronENST00000398879ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-
Frame-shiftENST00000442536ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000442536ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000442536ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000442536ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000442536ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000442536ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-intronENST00000442536ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-
Frame-shiftENST00000458317ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000458317ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000458317ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000458317ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000458317ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-5UTRENST00000458317ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
5CDS-intronENST00000458317ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-3CDSENST00000474346ENST00000341056TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-5UTRENST00000474346ENST00000396045TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-5UTRENST00000474346ENST00000310758TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-5UTRENST00000474346ENST00000396040TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-5UTRENST00000474346ENST00000442504TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-5UTRENST00000474346ENST00000448602TNS3chr7

47451325

-ELMO1chr7

36934622

-
intron-intronENST00000474346ENST00000479447TNS3chr7

47451325

-ELMO1chr7

36934622

-

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FusionProtFeatures for TNS3_ELMO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNS3

Q68CZ2

ELMO1

Q92556

May play a role in actin remodeling. Involved in thedissociation of the integrin-tensin-actin complex. EGF activatesTNS4 and down-regulates TNS3 which results in capping the tail ofITGB1. Seems to be involved in mammary cell migration. May beinvolved in cell migration and bone development (By similarity).{ECO:0000250, ECO:0000269|PubMed:17643115}. Involved in cytoskeletal rearrangements required forphagocytosis of apoptotic cells and cell motility. Acts inassociation with DOCK1 and CRK. Was initially proposed to berequired in complex with DOCK1 to activate Rac Rho small GTPases.May enhance the guanine nucleotide exchange factor (GEF) activityof DOCK1. {ECO:0000269|PubMed:11595183,ECO:0000269|PubMed:12134158}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNS3_ELMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNS3_ELMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNS3MAT2B, APOA1, ERBB2, ERBB3, PTPN12, DNPEP, GANAB, TRIM47, ENO1, MOV10, NXF1, EGFR, SRPK2, XPO1, CTNNAL1, DMD, DTNB, PYCR2, SNTB1, SNTB2, UTRN, EPHA4, TRIM25ELMO1HCK, DOCK1, BAG3, PTGS2, TRIM54, ZNF398, DOCK4, DOCK3, USP4, MED31, DOCK5, TTC19, ELMO2, CALML3, NTRK1, RHOG, DOCK2, BAI1, BAI3, ARL4A, CDC27, ARHGEF16, ELMO3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNS3_ELMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNS3_ELMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELMO1C0011881Diabetic Nephropathy1CTD_human
TgeneELMO1C0038325Stevens-Johnson Syndrome1CTD_human
TgeneELMO1C0279628Adenocarcinoma Of Esophagus1CTD_human