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Fusion gene ID: 39003 |
FusionGeneSummary for TNS1_FAP |
Fusion gene summary |
Fusion gene information | Fusion gene name: TNS1_FAP | Fusion gene ID: 39003 | Hgene | Tgene | Gene symbol | TNS1 | FAP | Gene ID | 7145 | 11146 |
Gene name | tensin 1 | glomulin, FKBP associated protein | |
Synonyms | MST091|MST122|MST127|MSTP091|MSTP122|MSTP127|MXRA6|PPP1R155|TNS | FAP|FAP48|FAP68|FKBPAP|GLML|GVM|VMGLOM | |
Cytomap | 2q35 | 1p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tensin-1Matrix-remodelling-associated protein 6matrix-remodelling associated 6protein phosphatase 1, regulatory subunit 155 | glomulinFK506-binding protein-associated proteinFKBP-associated protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HBL0 | Q12884 | |
Ensembl transtripts involved in fusion gene | ENST00000171887, ENST00000419504, ENST00000430930, ENST00000310858, ENST00000480665, | ENST00000188790, ENST00000443424, ENST00000493182, | |
Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 4 X 5 X 3=60 |
# samples | 9 | 4 | |
** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNS1 [Title/Abstract] AND FAP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FAP | GO:0042130 | negative regulation of T cell proliferation | 12604780 |
Tgene | FAP | GO:0042327 | positive regulation of phosphorylation | 11571281 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-18-3421-01A | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000171887 | ENST00000188790 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-intron | ENST00000171887 | ENST00000443424 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000171887 | ENST00000493182 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000419504 | ENST00000188790 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-intron | ENST00000419504 | ENST00000443424 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000419504 | ENST00000493182 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000430930 | ENST00000188790 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-intron | ENST00000430930 | ENST00000443424 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000430930 | ENST00000493182 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000310858 | ENST00000188790 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-intron | ENST00000310858 | ENST00000443424 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000310858 | ENST00000493182 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000480665 | ENST00000188790 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-intron | ENST00000480665 | ENST00000443424 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
intron-5UTR | ENST00000480665 | ENST00000493182 | TNS1 | chr2 | 218843488 | - | FAP | chr2 | 163100010 | - |
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FusionProtFeatures for TNS1_FAP |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TNS1 | FAP |
Involved in fibrillar adhesion formation. May beinvolved in cell migration, cartilage development and in linkingsignal transduction pathways to the cytoskeleton.{ECO:0000269|PubMed:21768292}. | Cell surface glycoprotein serine protease thatparticipates in extracellular matrix degradation and involved inmany cellular processes including tissue remodeling, fibrosis,wound healing, inflammation and tumor growth. Both plasma membraneand soluble forms exhibit post-proline cleaving endopeptidaseactivity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Alaconsensus sequences, on substrate such as alpha-2-antiplasminSERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769,PubMed:16480718, PubMed:16410248, PubMed:17381073,PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade alsogelatin, heat-denatured type I collagen, but not native collagentype I and IV, vibronectin, tenascin, laminin, fibronectin, fibrinor casein (PubMed:9065413, PubMed:2172980, PubMed:7923219,PubMed:10347120, PubMed:10455171, PubMed:12376466,PubMed:16223769, PubMed:16651416, PubMed:18095711). Have alsodipeptidyl peptidase activity, exhibiting the ability to hydrolyzethe prolyl bond two residues from the N-terminus of syntheticdipeptide substrates provided that the penultimate residue isproline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Proand Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601,PubMed:16223769, PubMed:16651416, PubMed:16410248,PubMed:17381073, PubMed:21314817, PubMed:24371721,PubMed:24717288). Natural neuropeptide hormones for dipeptidylpeptidase are the neuropeptide Y (NPY), peptide YY (PYY),substance P (TAC1) and brain natriuretic peptide 32 (NPPB)(PubMed:21314817). The plasma membrane form, in association witheither DPP4, PLAUR or integrins, is involved in the pericellularproteolysis of the extracellular matrix (ECM), and hence promotescell adhesion, migration and invasion through the ECM. Plays arole in tissue remodeling during development and wound healing.Participates in the cell invasiveness towards the ECM in malignantmelanoma cancers. Enhances tumor growth progression by increasingangiogenesis, collagen fiber degradation and apoptosis and byreducing antitumor response of the immune system. Promotes gliomacell invasion through the brain parenchyma by degrading theproteoglycan brevican. Acts as a tumor suppressor in melanocyticcells through regulation of cell proliferation and survival in aserine protease activity-independent manner.{ECO:0000250|UniProtKB:P97321, ECO:0000269|PubMed:10347120,ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10593948,ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14751930,ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16223769,ECO:0000269|PubMed:16410248, ECO:0000269|PubMed:16480718,ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646,ECO:0000269|PubMed:17381073, ECO:0000269|PubMed:18095711,ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:21288888,ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:2172980,ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:24717288,ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNS1_FAP |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNS1_FAP |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNS1 | BCAR1, NPHP1, YWHAZ, KLF10, OSGEP, PPP1CC, FRS3, BABAM1, BRCC3, CSK, CTNNAL1, DMD, DTNB, FAM175B, SNTB1, SNTB2, SORBS3, UTRN, TENC1 | FAP | PLAUR, SH3KBP1, HUWE1, CORO1C, ADA, CAV1, DPP4, ERLIN2, STOM, PHB, PHB2, MSRB1, RBM4, THY1, TMEM109, RBM3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNS1_FAP |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNS1_FAP |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |