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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39003

FusionGeneSummary for TNS1_FAP

check button Fusion gene summary
Fusion gene informationFusion gene name: TNS1_FAP
Fusion gene ID: 39003
HgeneTgene
Gene symbol

TNS1

FAP

Gene ID

7145

11146

Gene nametensin 1glomulin, FKBP associated protein
SynonymsMST091|MST122|MST127|MSTP091|MSTP122|MSTP127|MXRA6|PPP1R155|TNSFAP|FAP48|FAP68|FKBPAP|GLML|GVM|VMGLOM
Cytomap

2q35

1p22.1

Type of geneprotein-codingprotein-coding
Descriptiontensin-1Matrix-remodelling-associated protein 6matrix-remodelling associated 6protein phosphatase 1, regulatory subunit 155glomulinFK506-binding protein-associated proteinFKBP-associated protein
Modification date2018051920180523
UniProtAcc

Q9HBL0

Q12884

Ensembl transtripts involved in fusion geneENST00000171887, ENST00000419504, 
ENST00000430930, ENST00000310858, 
ENST00000480665, 
ENST00000188790, 
ENST00000443424, ENST00000493182, 
Fusion gene scores* DoF score9 X 7 X 6=3784 X 5 X 3=60
# samples 94
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNS1 [Title/Abstract] AND FAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAP

GO:0042130

negative regulation of T cell proliferation

12604780

TgeneFAP

GO:0042327

positive regulation of phosphorylation

11571281


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-18-3421-01ATNS1chr2

218843488

-FAPchr2

163100010

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000171887ENST00000188790TNS1chr2

218843488

-FAPchr2

163100010

-
intron-intronENST00000171887ENST00000443424TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000171887ENST00000493182TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000419504ENST00000188790TNS1chr2

218843488

-FAPchr2

163100010

-
intron-intronENST00000419504ENST00000443424TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000419504ENST00000493182TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000430930ENST00000188790TNS1chr2

218843488

-FAPchr2

163100010

-
intron-intronENST00000430930ENST00000443424TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000430930ENST00000493182TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000310858ENST00000188790TNS1chr2

218843488

-FAPchr2

163100010

-
intron-intronENST00000310858ENST00000443424TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000310858ENST00000493182TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000480665ENST00000188790TNS1chr2

218843488

-FAPchr2

163100010

-
intron-intronENST00000480665ENST00000443424TNS1chr2

218843488

-FAPchr2

163100010

-
intron-5UTRENST00000480665ENST00000493182TNS1chr2

218843488

-FAPchr2

163100010

-

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FusionProtFeatures for TNS1_FAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNS1

Q9HBL0

FAP

Q12884

Involved in fibrillar adhesion formation. May beinvolved in cell migration, cartilage development and in linkingsignal transduction pathways to the cytoskeleton.{ECO:0000269|PubMed:21768292}. Cell surface glycoprotein serine protease thatparticipates in extracellular matrix degradation and involved inmany cellular processes including tissue remodeling, fibrosis,wound healing, inflammation and tumor growth. Both plasma membraneand soluble forms exhibit post-proline cleaving endopeptidaseactivity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Alaconsensus sequences, on substrate such as alpha-2-antiplasminSERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769,PubMed:16480718, PubMed:16410248, PubMed:17381073,PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade alsogelatin, heat-denatured type I collagen, but not native collagentype I and IV, vibronectin, tenascin, laminin, fibronectin, fibrinor casein (PubMed:9065413, PubMed:2172980, PubMed:7923219,PubMed:10347120, PubMed:10455171, PubMed:12376466,PubMed:16223769, PubMed:16651416, PubMed:18095711). Have alsodipeptidyl peptidase activity, exhibiting the ability to hydrolyzethe prolyl bond two residues from the N-terminus of syntheticdipeptide substrates provided that the penultimate residue isproline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Proand Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601,PubMed:16223769, PubMed:16651416, PubMed:16410248,PubMed:17381073, PubMed:21314817, PubMed:24371721,PubMed:24717288). Natural neuropeptide hormones for dipeptidylpeptidase are the neuropeptide Y (NPY), peptide YY (PYY),substance P (TAC1) and brain natriuretic peptide 32 (NPPB)(PubMed:21314817). The plasma membrane form, in association witheither DPP4, PLAUR or integrins, is involved in the pericellularproteolysis of the extracellular matrix (ECM), and hence promotescell adhesion, migration and invasion through the ECM. Plays arole in tissue remodeling during development and wound healing.Participates in the cell invasiveness towards the ECM in malignantmelanoma cancers. Enhances tumor growth progression by increasingangiogenesis, collagen fiber degradation and apoptosis and byreducing antitumor response of the immune system. Promotes gliomacell invasion through the brain parenchyma by degrading theproteoglycan brevican. Acts as a tumor suppressor in melanocyticcells through regulation of cell proliferation and survival in aserine protease activity-independent manner.{ECO:0000250|UniProtKB:P97321, ECO:0000269|PubMed:10347120,ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10593948,ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14751930,ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16223769,ECO:0000269|PubMed:16410248, ECO:0000269|PubMed:16480718,ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646,ECO:0000269|PubMed:17381073, ECO:0000269|PubMed:18095711,ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:21288888,ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:2172980,ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:24717288,ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNS1_FAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNS1_FAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNS1BCAR1, NPHP1, YWHAZ, KLF10, OSGEP, PPP1CC, FRS3, BABAM1, BRCC3, CSK, CTNNAL1, DMD, DTNB, FAM175B, SNTB1, SNTB2, SORBS3, UTRN, TENC1FAPPLAUR, SH3KBP1, HUWE1, CORO1C, ADA, CAV1, DPP4, ERLIN2, STOM, PHB, PHB2, MSRB1, RBM4, THY1, TMEM109, RBM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNS1_FAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNS1_FAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource