FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38998

FusionGeneSummary for TNRC6C_RIN3

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6C_RIN3
Fusion gene ID: 38998
HgeneTgene
Gene symbol

TNRC6C

RIN3

Gene ID

57690

79890

Gene nametrinucleotide repeat containing 6CRas and Rab interactor 3
Synonyms--
Cytomap

17q25.3

14q32.12

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6C proteinras and Rab interactor 3RAB5 interacting protein 3ras interaction/interference protein 3
Modification date2018051920180522
UniProtAcc

Q9HCJ0

Q8TB24

Ensembl transtripts involved in fusion geneENST00000588847, ENST00000588061, 
ENST00000335749, ENST00000301624, 
ENST00000541771, ENST00000544502, 
ENST00000216487, ENST00000418924, 
ENST00000557762, 
Fusion gene scores* DoF score7 X 6 X 4=1687 X 8 X 5=280
# samples 810
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC6C [Title/Abstract] AND RIN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNRC6C

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

21984185

HgeneTNRC6C

GO:1900153

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

21984185


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI021858TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
ChiTaRS3.1BI021859TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000588847ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000588847ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000588847ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000588061ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000588061ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000588061ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000335749ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000335749ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000335749ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000301624ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000301624ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000301624ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000541771ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000541771ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000541771ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000544502ENST00000216487TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000544502ENST00000418924TNRC6Cchr17

76089913

-RIN3chr14

93097760

-
intron-intronENST00000544502ENST00000557762TNRC6Cchr17

76089913

-RIN3chr14

93097760

-

Top

FusionProtFeatures for TNRC6C_RIN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC6C

Q9HCJ0

RIN3

Q8TB24

Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translationalrepression of complementary mRNAs by argonaute family proteins. Asscaffoldng protein associates with argonaute proteins bound topartially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925,ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184,ECO:0000269|PubMed:21984185}. Ras effector protein that functions as a guaninenucleotide exchange (GEF) for RAB5B and RAB31, by exchanging boundGDP for free GTP. Required for normal RAB31 function.{ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TNRC6C_RIN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TNRC6C_RIN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TNRC6C_RIN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TNRC6C_RIN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRIN3C0029401Osteitis Deformans1CTD_human