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Fusion gene ID: 38993 |
FusionGeneSummary for TNRC6B_ZC3H7B |
Fusion gene summary |
Fusion gene information | Fusion gene name: TNRC6B_ZC3H7B | Fusion gene ID: 38993 | Hgene | Tgene | Gene symbol | TNRC6B | ZC3H7B | Gene ID | 23112 | 23264 |
Gene name | trinucleotide repeat containing 6B | zinc finger CCCH-type containing 7B | |
Synonyms | - | RoXaN | |
Cytomap | 22q13.1 | 22q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | trinucleotide repeat-containing gene 6B protein | zinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9UPQ9 | Q9UGR2 | |
Ensembl transtripts involved in fusion gene | ENST00000301923, ENST00000402203, ENST00000454349, ENST00000335727, ENST00000497559, | ENST00000352645, ENST00000351589, | |
Fusion gene scores | * DoF score | 19 X 13 X 12=2964 | 6 X 6 X 4=144 |
# samples | 23 | 7 | |
** MAII score | log2(23/2964*10)=-3.68783968136146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNRC6B [Title/Abstract] AND ZC3H7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-7659-01A | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000301923 | ENST00000352645 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
5UTR-3CDS | ENST00000301923 | ENST00000351589 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000402203 | ENST00000352645 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000402203 | ENST00000351589 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000454349 | ENST00000352645 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000454349 | ENST00000351589 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000335727 | ENST00000352645 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000335727 | ENST00000351589 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000497559 | ENST00000352645 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
intron-3CDS | ENST00000497559 | ENST00000351589 | TNRC6B | chr22 | 40441002 | + | ZC3H7B | chr22 | 41751473 | + |
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FusionProtFeatures for TNRC6B_ZC3H7B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TNRC6B | ZC3H7B |
Plays a role in RNA-mediated gene silencing by bothmicro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Requiredfor miRNA-dependent translational repression and siRNA-dependentendonucleolytic cleavage of complementary mRNAs by argonautefamily proteins. As scaffoldng protein associates with argonauteproteins bound to partially complementary mRNAs and simultaneouslycan recruit CCR4-NOT and PAN deadenylase complexes.{ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051,ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNRC6B_ZC3H7B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNRC6B_ZC3H7B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TNRC6B | AGO1, AGO2, GIGYF2, UBC, AGO3, AGO4, PABPC1, CUL3, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, UBQLN4, LATS2, SAV1, CARM1, APBA3, CSK, FBRS, GMPS, NUP155, FLAD1, CHEK1, GARS, TRIM65, PFAS, NXF1, BMI1, CNOT1, CNOT2, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT3, PAN3, BTRC, MED4, MED23, SSX2IP, OFD1, B9D2, MKS1, CEP97, CEP104, CEP120, CEP152, CNTROB, CEP128, CEP135, CEP44, CEP63, CNTRL, FBF1, NINL, NIN, NPHP1, ODF2, RPGRIP1L, SCLT1, SASS6, RPGRIP1, STIL, CENPJ, CLTC, KAT6A, GTSE1, RNASEH2B, G3BP1, BRCA1 | ZC3H7B | ATXN1, ATXN1L, ZYX, UBXN6, RC3H1, HSP90AA1, HECW2, MOV10, NXF1, TRIM25, G3BP1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNRC6B_ZC3H7B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNRC6B_ZC3H7B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TNRC6B | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |