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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38964

FusionGeneSummary for TNRC18_TGS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC18_TGS1
Fusion gene ID: 38964
HgeneTgene
Gene symbol

TNRC18

TGS1

Gene ID

84629

286826

Gene nametrinucleotide repeat containing 18lin-9 DREAM MuvB core complex component
SynonymsCAGL79|TNRC18ABARA|BARPsv|Lin-9|TGS|TGS1|TGS2
Cytomap

7p22.1

1q42.12

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 proteinprotein lin-9 homologTUDOR gene similar proteinbeta subunit-associated regulator of apoptosislin-9 homologpRB-associated proteinrb related pathway actortype I interferon receptor beta chain-associated protein
Modification date2018052220180523
UniProtAcc

O15417

Q96RS0

Ensembl transtripts involved in fusion geneENST00000399537, ENST00000430969, 
ENST00000399434, 
ENST00000260129, 
Fusion gene scores* DoF score16 X 15 X 8=19203 X 4 X 3=36
# samples 253
** MAII scorelog2(25/1920*10)=-2.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC18 [Title/Abstract] AND TGS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-MP-A4T9-01ATNRC18chr7

5410006

-TGS1chr8

56723440

+
TCGALDLUADTCGA-MP-A4T9-01ATNRC18chr7

5410006

-TGS1chr8

56725614

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000399537ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56723440

+
Frame-shiftENST00000430969ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56723440

+
intron-3CDSENST00000399434ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56723440

+
Frame-shiftENST00000399537ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56725614

+
Frame-shiftENST00000430969ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56725614

+
intron-3CDSENST00000399434ENST00000260129TNRC18chr7

5410006

-TGS1chr8

56725614

+

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FusionProtFeatures for TNRC18_TGS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC18

O15417

TGS1

Q96RS0

Catalyzes the 2 serial methylation steps for theconversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs andsnoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure.The enzyme is specific for guanine, and N7 methylation mustprecede N2 methylation. Hypermethylation of the m7G cap of UsnRNAs leads to their concentration in nuclear foci, theircolocalization with coilin and the formation of canonical Cajalbodies (CBs). Plays a role in transcriptional regulation.{ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212,ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNRC18_TGS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNRC18_TGS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNRC18SOX2, HDAC1, EDA, KRAS, XRCC6, NIPSNAP1, SAP30, SIN3B, COPS7A, GATAD1, FAM60A, MDK, PRDM5, PES1, CAMKV, TRIM25TGS1EED, CREBBP, EP300, NCOA6, MED1, HNF4A, COIL, LIN28A, SNRPA1, FBL, FAM177A1, XPO1, SEPT7, CRY1, ERCC5, MYBPH, SEPT2, SORBS1, MAGED2, AFG3L2, DNAJB4, ZZEF1, SCRIB, RSRC1, ZMYM1, LSM10, SNCA, SSX2IP, LSM11, SEPT10, SNRPN, SNRPF, SNRPE, SNRPG, SNRNP70, TGS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC18_TGS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNRC18_TGS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource