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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38955

FusionGeneSummary for TNRC18_GLS

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC18_GLS
Fusion gene ID: 38955
HgeneTgene
Gene symbol

TNRC18

GLS

Gene ID

84629

27165

Gene nametrinucleotide repeat containing 18glutaminase 2
SynonymsCAGL79|TNRC18AGA|GLS|LGA|hLGA
Cytomap

7p22.1

12q13.3

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 proteinglutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminase
Modification date2018052220180523
UniProtAcc

O15417

O94925

Ensembl transtripts involved in fusion geneENST00000399537, ENST00000430969, 
ENST00000399434, 
ENST00000320717, 
ENST00000338435, ENST00000409626, 
ENST00000409428, ENST00000409215, 
ENST00000471443, 
Fusion gene scores* DoF score16 X 15 X 8=19208 X 7 X 3=168
# samples 258
** MAII scorelog2(25/1920*10)=-2.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC18 [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE179808TNRC18chr7

5437606

+GLSchr2

191762328

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000399537ENST00000320717TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399537ENST00000338435TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399537ENST00000409626TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399537ENST00000409428TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399537ENST00000409215TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399537ENST00000471443TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000320717TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000338435TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000409626TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000409428TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000409215TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000430969ENST00000471443TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000320717TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000338435TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000409626TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000409428TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000409215TNRC18chr7

5437606

+GLSchr2

191762328

-
intron-intronENST00000399434ENST00000471443TNRC18chr7

5437606

+GLSchr2

191762328

-

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FusionProtFeatures for TNRC18_GLS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNRC18

O15417

GLS

O94925

Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNRC18_GLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNRC18_GLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNRC18_GLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGLSO94925DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for TNRC18_GLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGLSC0000786Spontaneous abortion1CTD_human
TgeneGLSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGLSC0029408Degenerative polyarthritis1CTD_human
TgeneGLSC0036341Schizophrenia1PSYGENET