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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38915

FusionGeneSummary for TNKS_GPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: TNKS_GPC3
Fusion gene ID: 38915
HgeneTgene
Gene symbol

TNKS

GPC3

Gene ID

8658

2719

Gene nametankyraseglypican 3
SynonymsARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5DGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1
Cytomap

8p23.1

Xq26.2

Type of geneprotein-codingprotein-coding
Descriptiontankyrase-1ADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerase 1poly [ADP-ribose] polymerase 5Atankyrase Itankyrase, TRF1-interacting ankyrin-related ADP-ribose polymeraseglypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3
Modification date2018052320180527
UniProtAcc

O95271

P51654

Ensembl transtripts involved in fusion geneENST00000520408, ENST00000310430, 
ENST00000518281, ENST00000522110, 
ENST00000518027, 
ENST00000370818, 
ENST00000394299, ENST00000543339, 
Fusion gene scores* DoF score6 X 5 X 6=1807 X 6 X 4=168
# samples 67
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNKS [Title/Abstract] AND GPC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS

GO:0006471

protein ADP-ribosylation

9822378|15133513|21270334

HgeneTNKS

GO:0018105

peptidyl-serine phosphorylation

17026964

HgeneTNKS

GO:0018107

peptidyl-threonine phosphorylation

17026964

HgeneTNKS

GO:0032212

positive regulation of telomere maintenance via telomerase

12782650|18221737

HgeneTNKS

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366

HgeneTNKS

GO:0051973

positive regulation of telomerase activity

12782650

HgeneTNKS

GO:0070212

protein poly-ADP-ribosylation

9822378|16076287

HgeneTNKS

GO:0070213

protein auto-ADP-ribosylation

9822378|15133513|19759537|21478859

HgeneTNKS

GO:1904355

positive regulation of telomere capping

21531765

HgeneTNKS

GO:1904743

negative regulation of telomeric DNA binding

9822378


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1R64084TNKSchr8

9637105

+GPC3chrX

132669842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000520408ENST00000370818TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000520408ENST00000394299TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-intronENST00000520408ENST00000543339TNKSchr8

9637105

+GPC3chrX

132669842

-
3UTR-3UTRENST00000310430ENST00000370818TNKSchr8

9637105

+GPC3chrX

132669842

-
3UTR-3UTRENST00000310430ENST00000394299TNKSchr8

9637105

+GPC3chrX

132669842

-
3UTR-intronENST00000310430ENST00000543339TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000518281ENST00000370818TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000518281ENST00000394299TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-intronENST00000518281ENST00000543339TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000522110ENST00000370818TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000522110ENST00000394299TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-intronENST00000522110ENST00000543339TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000518027ENST00000370818TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-3UTRENST00000518027ENST00000394299TNKSchr8

9637105

+GPC3chrX

132669842

-
intron-intronENST00000518027ENST00000543339TNKSchr8

9637105

+GPC3chrX

132669842

-

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FusionProtFeatures for TNKS_GPC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNKS

O95271

GPC3

P51654

Poly-ADP-ribosyltransferase involved in variousprocesses such as Wnt signaling pathway, telomere length andvesicle trafficking. Acts as an activator of the Wnt signalingpathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1and AXIN2, 2 key components of the beta-catenin destructioncomplex: poly-ADP-ribosylated target proteins are recognized byRNF146, which mediates their ubiquitination and subsequentdegradation. Also mediates PARsylation of BLZF1 and CASC3,followed by recruitment of RNF146 and subsequent ubiquitination.Mediates PARsylation of TERF1, thereby contributing to theregulation of telomere length. Involved in centrosome maturationduring prometaphase by mediating PARsylation of HEPACAM2/MIKI. Mayalso regulate vesicle trafficking and modulate the subcellulardistribution of SLC2A4/GLUT4-vesicles. May be involved in spindlepole assembly through PARsylation of NUMA1. Stimulates 26Sproteasome activity. {ECO:0000269|PubMed:10988299,ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287,ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859,ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245}. Cell surface proteoglycan that bears heparan sulfate.Inhibits the dipeptidyl peptidase activity of DPP4. May beinvolved in the suppression/modulation of growth in thepredominantly mesodermal tissues and organs. May play a role inthe modulation of IGF2 interactions with its receptor and therebymodulate its function. May regulate growth and tumorpredisposition. {ECO:0000269|PubMed:17549790}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNKS_GPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNKS_GPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNKS_GPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNKS_GPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPC3C0025500Mesothelioma1CTD_human
TgeneGPC3C0796154SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 11CTD_human;ORPHANET;UNIPROT
TgeneGPC3C2239176Liver carcinoma1CTD_human