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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38911

FusionGeneSummary for TNKS2_FAM107B

check button Fusion gene summary
Fusion gene informationFusion gene name: TNKS2_FAM107B
Fusion gene ID: 38911
HgeneTgene
Gene symbol

TNKS2

FAM107B

Gene ID

80351

83641

Gene nametankyrase 2family with sequence similarity 107 member B
SynonymsARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6C10orf45|HITS
Cytomap

10q23.32

10p13

Type of geneprotein-codingprotein-coding
Descriptiontankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Btankyrase IItankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2tankyrase-like protprotein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein
Modification date2018052320180519
UniProtAcc

Q9H2K2

Q9H098

Ensembl transtripts involved in fusion geneENST00000371627, ENST00000181796, 
ENST00000378470, ENST00000468747, 
ENST00000378467, ENST00000378465, 
ENST00000378458, ENST00000478076, 
ENST00000378462, ENST00000496330, 
ENST00000479731, ENST00000471815, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 7 X 6=378
# samples 59
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNKS2 [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS2

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS2

GO:0006471

protein ADP-ribosylation

11739745

HgeneTNKS2

GO:0070213

protein auto-ADP-ribosylation

19759537|21478859

HgeneTNKS2

GO:1904355

positive regulation of telomere capping

21531765


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-6456-01ATNKS2chr10

93602148

+FAM107Bchr10

14709690

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000371627ENST00000181796TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000378470TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000468747TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000378467TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000378465TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000378458TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000478076TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000378462TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000496330TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000479731TNKS2chr10

93602148

+FAM107Bchr10

14709690

-
5CDS-intronENST00000371627ENST00000471815TNKS2chr10

93602148

+FAM107Bchr10

14709690

-

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FusionProtFeatures for TNKS2_FAM107B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNKS2

Q9H2K2

FAM107B

Q9H098

Poly-ADP-ribosyltransferase involved in variousprocesses such as Wnt signaling pathway, telomere length andvesicle trafficking. Acts as an activator of the Wnt signalingpathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, whichmediates their ubiquitination and subsequent degradation. Alsomediates poly-ADP-ribosylation of BLZF1 and CASC3, followed byrecruitment of RNF146 and subsequent ubiquitination. Mediatespoly-ADP-ribosylation of TERF1, thereby contributing to theregulation of telomere length. May also regulate vesicletrafficking and modulate the subcellular distribution ofSLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.{ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774,ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859,ECO:0000269|PubMed:23622245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNKS2_FAM107B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNKS2_FAM107B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNKS2TERF1, TNKS1BP1, LNPEP, MAPK1, GRB14, FTCD, SH3BP2, CUL5, ZNF512B, BABAM1, EPN3, SLC35A5, AP2M1, RNF166, PTEN, TNKS2, HIF1AN, GMDS, SSSCA1, FAM117B, SH3BP5L, MAPK8IP3, LRP1, CHD1L, CELF5, NANOS2, TRIM25FAM107BELAVL1, BAG3, U2AF2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNKS2_FAM107B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNKS2_FAM107B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource