|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38908 |
FusionGeneSummary for TNKS2_BTBD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNKS2_BTBD2 | Fusion gene ID: 38908 | Hgene | Tgene | Gene symbol | TNKS2 | BTBD2 | Gene ID | 80351 | 55643 |
| Gene name | tankyrase 2 | BTB domain containing 2 | |
| Synonyms | ARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6 | - | |
| Cytomap | 10q23.32 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Btankyrase IItankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2tankyrase-like prot | BTB/POZ domain-containing protein 2BTB (POZ) domain containing 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H2K2 | Q9BX70 | |
| Ensembl transtripts involved in fusion gene | ENST00000371627, | ENST00000255608, ENST00000590646, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 5 X 3 X 4=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNKS2 [Title/Abstract] AND BTBD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNKS2 | GO:0000209 | protein polyubiquitination | 19759537|21478859 |
| Hgene | TNKS2 | GO:0006471 | protein ADP-ribosylation | 11739745 |
| Hgene | TNKS2 | GO:0070213 | protein auto-ADP-ribosylation | 19759537|21478859 |
| Hgene | TNKS2 | GO:1904355 | positive regulation of telomere capping | 21531765 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC023218 | TNKS2 | chr10 | 93608181 | + | BTBD2 | chr19 | 1985500 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000371627 | ENST00000255608 | TNKS2 | chr10 | 93608181 | + | BTBD2 | chr19 | 1985500 | - |
| 5CDS-intron | ENST00000371627 | ENST00000590646 | TNKS2 | chr10 | 93608181 | + | BTBD2 | chr19 | 1985500 | - |
Top |
FusionProtFeatures for TNKS2_BTBD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNKS2 | BTBD2 |
| Poly-ADP-ribosyltransferase involved in variousprocesses such as Wnt signaling pathway, telomere length andvesicle trafficking. Acts as an activator of the Wnt signalingpathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, whichmediates their ubiquitination and subsequent degradation. Alsomediates poly-ADP-ribosylation of BLZF1 and CASC3, followed byrecruitment of RNF146 and subsequent ubiquitination. Mediatespoly-ADP-ribosylation of TERF1, thereby contributing to theregulation of telomere length. May also regulate vesicletrafficking and modulate the subcellular distribution ofSLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.{ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774,ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859,ECO:0000269|PubMed:23622245}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TNKS2_BTBD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TNKS2_BTBD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TNKS2_BTBD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TNKS2_BTBD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|