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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38901

FusionGeneSummary for TNK2_RNF187

check button Fusion gene summary
Fusion gene informationFusion gene name: TNK2_RNF187
Fusion gene ID: 38901
HgeneTgene
Gene symbol

TNK2

RNF187

Gene ID

10188

149603

Gene nametyrosine kinase non receptor 2ring finger protein 187
SynonymsACK|ACK-1|ACK1|p21cdc42HsRACO-1|RACO1
Cytomap

3q29

1q42.13

Type of geneprotein-codingprotein-coding
Descriptionactivated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2E3 ubiquitin-protein ligase RNF187RING domain AP1 coactivator 1RING-type E3 ubiquitin transferase RNF187protein RNF187ring domain AP-1 co-activator 1
Modification date2018052320180519
UniProtAcc

Q07912

Q5TA31

Ensembl transtripts involved in fusion geneENST00000381916, ENST00000333602, 
ENST00000428187, ENST00000392400, 
ENST00000316664, ENST00000468819, 
ENST00000305943, ENST00000482739, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TNK2 [Title/Abstract] AND RNF187 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNK2

GO:0016310

phosphorylation

20333297|20979614

HgeneTNK2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10587647

HgeneTNK2

GO:2000369

regulation of clathrin-dependent endocytosis

18262180

TgeneRNF187

GO:0051865

protein autoubiquitination

20852630


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ713023TNK2chr3

195599151

-RNF187chr1

228682475

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000381916ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000381916ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000333602ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000333602ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000428187ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000428187ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000392400ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000392400ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000316664ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
5CDS-3UTRENST00000316664ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+
intron-3UTRENST00000468819ENST00000305943TNK2chr3

195599151

-RNF187chr1

228682475

+
intron-3UTRENST00000468819ENST00000482739TNK2chr3

195599151

-RNF187chr1

228682475

+

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FusionProtFeatures for TNK2_RNF187


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNK2

Q07912

RNF187

Q5TA31

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration,cell survival, cell growth and proliferation. Transducesextracellular signals to cytosolic and nuclear effectors.Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated intrafficking and clathrin-mediated endocytosis through binding toepidermal growth factor receptor (EGFR) and clathrin. Binds toboth poly- and mono-ubiquitin and regulates ligand-induceddegradation of EGFR, thereby contributing to the accumulation ofEGFR at the limiting membrane of early endosomes. Downstreameffector of CDC42 which mediates CDC42-dependent cell migrationvia phosphorylation of BCAR1. May be involved both in adultsynaptic function and plasticity and in brain development.Activates AKT1 by phosphorylating it on 'Tyr-176'. PhosphorylatesAR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment toandrogen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as aguanine nucleotide exchange factor (GEF) toward Rho familyproteins. Contributes to the control of AXL receptor levels.Confers metastatic properties on cancer cells and promotes tumorgrowth by negatively regulating tumor suppressor such as WWOX andpositively regulating pro-survival factors such as AKT1 and AR.Phosphorylates WASP (PubMed:20110370).{ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436,ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963,ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317,ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854,ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. E3 ubiquitin-protein ligase that acts as a coactivatorof JUN-mediated gene activation in response to growth factorsignaling via the MAP3K1 pathway, independently from MAPK8.{ECO:0000269|PubMed:20852630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNK2_RNF187


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNK2_RNF187


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNK2_RNF187


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNK2_RNF187


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNK2C0023903Liver neoplasms1CTD_human
HgeneTNK2C0032927Precancerous Conditions1CTD_human