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Fusion gene ID: 38899 |
FusionGeneSummary for TNK2_CELF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TNK2_CELF1 | Fusion gene ID: 38899 | Hgene | Tgene | Gene symbol | TNK2 | CELF1 | Gene ID | 10188 | 10658 |
| Gene name | tyrosine kinase non receptor 2 | CUGBP Elav-like family member 1 | |
| Synonyms | ACK|ACK-1|ACK1|p21cdc42Hs | BRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50 | |
| Cytomap | 3q29 | 11p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | activated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2 | CUGBP Elav-like family member 150 kDa nuclear polyadenylated RNA-binding proteinCELF-1CUG RNA-binding proteinCUG triplet repeat RNA-binding protein 1CUG-BP- and ETR-3-like factor 1CUG-BP1EDEN-BP homologRNA-binding protein BRUNOL-2bruno-like 2bru | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q07912 | Q92879 | |
| Ensembl transtripts involved in fusion gene | ENST00000381916, ENST00000333602, ENST00000428187, ENST00000392400, ENST00000316664, ENST00000468819, | ENST00000395290, ENST00000358597, ENST00000395292, ENST00000310513, ENST00000361904, ENST00000539455, ENST00000531165, ENST00000532048, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 7 X 3=126 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TNK2 [Title/Abstract] AND CELF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNK2 | GO:0016310 | phosphorylation | 20333297|20979614 |
| Hgene | TNK2 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10587647 |
| Hgene | TNK2 | GO:2000369 | regulation of clathrin-dependent endocytosis | 18262180 |
| Tgene | CELF1 | GO:0006376 | mRNA splice site selection | 11158314 |
| Tgene | CELF1 | GO:0043484 | regulation of RNA splicing | 16946708 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF817488 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000381916 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000381916 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000381916 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000333602 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000333602 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000333602 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000428187 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000428187 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000428187 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000392400 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000392400 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000392400 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000316664 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000316664 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000316664 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000468819 | ENST00000395290 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000358597 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000395292 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000310513 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000361904 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000539455 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-3UTR | ENST00000468819 | ENST00000531165 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
| intron-intron | ENST00000468819 | ENST00000532048 | TNK2 | chr3 | 195597005 | - | CELF1 | chr11 | 47493282 | + |
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FusionProtFeatures for TNK2_CELF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNK2 | CELF1 |
| Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration,cell survival, cell growth and proliferation. Transducesextracellular signals to cytosolic and nuclear effectors.Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated intrafficking and clathrin-mediated endocytosis through binding toepidermal growth factor receptor (EGFR) and clathrin. Binds toboth poly- and mono-ubiquitin and regulates ligand-induceddegradation of EGFR, thereby contributing to the accumulation ofEGFR at the limiting membrane of early endosomes. Downstreameffector of CDC42 which mediates CDC42-dependent cell migrationvia phosphorylation of BCAR1. May be involved both in adultsynaptic function and plasticity and in brain development.Activates AKT1 by phosphorylating it on 'Tyr-176'. PhosphorylatesAR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment toandrogen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as aguanine nucleotide exchange factor (GEF) toward Rho familyproteins. Contributes to the control of AXL receptor levels.Confers metastatic properties on cancer cells and promotes tumorgrowth by negatively regulating tumor suppressor such as WWOX andpositively regulating pro-survival factors such as AKT1 and AR.Phosphorylates WASP (PubMed:20110370).{ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436,ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963,ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317,ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854,ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. | RNA-binding protein implicated in the regulation ofseveral post-transcriptional events. Involved in pre-mRNAalternative splicing, mRNA translation and stability. Mediatesexon inclusion and/or exclusion in pre-mRNA that are subject totissue-specific and developmentally regulated alternativesplicing. Specifically activates exon 5 inclusion of cardiacisoforms of TNNT2 during heart remodeling at the juvenile to adulttransition. Acts as both an activator and repressor of a pair ofcoregulated exons: promotes inclusion of the smooth muscle (SM)exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing therepressive effect of PTB. Promotes exclusion of exon 11 of theINSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor(IR) pre-mRNA exon 11 inclusion in myoblast. Increases translationand controls the choice of translation initiation codon of CEBPBmRNA. Increases mRNA translation of CEBPB in aging liver (Bysimilarity). Increases translation of CDKN1A mRNA by antagonizingthe repressive effect of CALR3. Mediates rapid cytoplasmic mRNAdeadenylation. Recruits the deadenylase PARN to the poly(A) tailof EDEN-containing mRNAs to promote their deadenylation. Requiredfor completion of spermatogenesis (By similarity). Binds to (CUG)ntriplet repeats in the 3'-UTR of transcripts such as DMPK and toBruno response elements (BREs). Binds to muscle-specific splicingenhancer (MSE) intronic sites flanking the alternative exon 5 ofTNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like)localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA.Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the5'-region of CEBPB mRNA in aging liver. May be a specificregulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing tomature miRNA (PubMed:28431233). {ECO:0000250,ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939,ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496,ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956,ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708,ECO:0000269|PubMed:28431233}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TNK2_CELF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TNK2_CELF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TNK2_CELF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNK2_CELF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TNK2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | TNK2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
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