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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38896

FusionGeneSummary for TNIP1_VIM-AS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIP1_VIM-AS1
Fusion gene ID: 38896
HgeneTgene
Gene symbol

TNIP1

VIM-AS1

Gene ID

10318

100507347

Gene nameTNFAIP3 interacting protein 1VIM antisense RNA 1
SynonymsABIN-1|NAF1|VAN|nip40-1-
Cytomap

5q33.1

10p13

Type of geneprotein-codingncRNA
DescriptionTNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein-
Modification date2018052220180421
UniProtAcc

Q15025

Ensembl transtripts involved in fusion geneENST00000520931, ENST00000389378, 
ENST00000523338, ENST00000315050, 
ENST00000522226, ENST00000518977, 
ENST00000521591, ENST00000524280, 
ENST00000523200, ENST00000521423, 
ENST00000437232, ENST00000605833, 
Fusion gene scores* DoF score7 X 4 X 4=1127 X 6 X 1=42
# samples 57
** MAII scorelog2(5/112*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TNIP1 [Title/Abstract] AND VIM-AS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIP1

GO:0009101

glycoprotein biosynthetic process

9923610

HgeneTNIP1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

16684768

HgeneTNIP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

12220502

HgeneTNIP1

GO:0085032

modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

20010814

HgeneTNIP1

GO:1903003

positive regulation of protein deubiquitination

16684768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA368174TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000520931ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000520931ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000389378ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000389378ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000523338ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000523338ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000315050ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000315050ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000522226ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000522226ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000518977ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000518977ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000521591ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000521591ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000524280ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000524280ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000523200ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000523200ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-intronENST00000521423ENST00000437232TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+
intron-5UTRENST00000521423ENST00000605833TNIP1chr5

150409573

+VIM-AS1chr10

17271771

+

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FusionProtFeatures for TNIP1_VIM-AS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNIP1

Q15025

VIM-AS1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNIP1_VIM-AS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNIP1_VIM-AS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNIP1TTF2, MAGEB18, TNFAIP3, MAPK1, TNF, IKBKG, UBC, TAX1BP1, IKBKE, TBK1, TRAF3, RARA, RARG, NFKB1, MYD88, SELPLG, PIK3R1, PIK3CD, RBFOX1, RNF11, CCNG1, GIT2, OPTN, ADH6, CDKN1A, EFEMP1, FUS, GTF2H1, PIN1, MAPK10, SUMO2, TNIP1, RABAC1, NME7, BYSL, EHHADH, GTF2B, KIFC3, TCEA2, ZBTB25, AP1M1, MORF4L2, NDC80, ZNHIT1, RALBP1, MORF4L1, PNKP, GABARAPL2, FAM168A, GABARAPL1, VPS33B, MAGEH1, CDIP1, SNIP1, TNIP3, MAP1LC3B, FAM161A, NIFK, MAP1LC3A, MOB1B, TCEANC2, SYT6, MOB3C, CCDC112, TXLNA, CFAP53, HDDC3, MAP3K1, CRHBP, GRAP2, SSX2IP, OFD1, PCM1, CEP97, CEP152, CEP135, CEP44, FBF1, NINL, ODF2, CENPJ, MCM10, TYRO3, CCDC121, ABHD17A, XPO1, TRAF1, ABI2, IKBIP, PIGT, SYNC, SAMD4A, HAO2, POTEF, ERP44, NAB2, EXOC1, CORO6VIM-AS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNIP1_VIM-AS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNIP1_VIM-AS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNIP1C0024141Lupus Erythematosus, Systemic2CTD_human
HgeneTNIP1C0033860Psoriasis2CTD_human
HgeneTNIP1C0036421Systemic Scleroderma1CTD_human
HgeneTNIP1C1458155Mammary Neoplasms1CTD_human
HgeneTNIP1C1527336Sjogren's Syndrome1CTD_human