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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38884

FusionGeneSummary for TNIK_DGCR8

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIK_DGCR8
Fusion gene ID: 38884
HgeneTgene
Gene symbol

TNIK

DGCR8

Gene ID

23043

54487

Gene nameTRAF2 and NCK interacting kinaseDGCR8, microprocessor complex subunit
SynonymsMRT54C22orf12|DGCRK6|Gy1|pasha
Cytomap

3q26.2-q26.31

22q11.21

Type of geneprotein-codingprotein-coding
DescriptionTRAF2 and NCK-interacting protein kinasemicroprocessor complex subunit DGCR8DiGeorge syndrome critical region 8DiGeorge syndrome critical region gene 8
Modification date2018052320180522
UniProtAcc

Q9UKE5

Q8WYQ5

Ensembl transtripts involved in fusion geneENST00000436636, ENST00000538048, 
ENST00000369326, ENST00000341852, 
ENST00000284483, ENST00000470834, 
ENST00000460047, ENST00000475336, 
ENST00000488470, ENST00000357327, 
ENST00000464785, ENST00000465393, 
ENST00000351989, ENST00000383024, 
ENST00000407755, 
Fusion gene scores* DoF score6 X 5 X 5=1506 X 5 X 4=120
# samples 58
** MAII scorelog2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNIK [Title/Abstract] AND DGCR8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIK

GO:0006468

protein phosphorylation

10521462|15342639|22797597

HgeneTNIK

GO:0007256

activation of JNKK activity

15342639

HgeneTNIK

GO:0031532

actin cytoskeleton reorganization

15342639

HgeneTNIK

GO:0035556

intracellular signal transduction

10521462

HgeneTNIK

GO:0046777

protein autophosphorylation

10521462|15342639

HgeneTNIK

GO:0048814

regulation of dendrite morphogenesis

20159449

TgeneDGCR8

GO:0031053

primary miRNA processing

15531877|15574589|24449907|24910438


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TM-A84B-01ATNIKchr3

170841385

-DGCR8chr22

20093700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000436636ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000436636ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000436636ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000538048ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000538048ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000538048ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000369326ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000369326ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000369326ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000341852ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000341852ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000341852ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000284483ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000284483ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000284483ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000470834ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000470834ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000470834ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000460047ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000460047ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000460047ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000475336ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000475336ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000475336ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000488470ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000488470ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000488470ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000357327ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000357327ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
Frame-shiftENST00000357327ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000464785ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000464785ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000464785ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000465393ENST00000351989TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000465393ENST00000383024TNIKchr3

170841385

-DGCR8chr22

20093700

+
intron-3CDSENST00000465393ENST00000407755TNIKchr3

170841385

-DGCR8chr22

20093700

+

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FusionProtFeatures for TNIK_DGCR8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNIK

Q9UKE5

DGCR8

Q8WYQ5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNIK_DGCR8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNIK_DGCR8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNIKTRAF2, NEDD4, DISC1, DST, SYNE1, TNKS, SOS1, SPTBN1, MACF1, PDE4DIP, GOLGA4, SRGAP3, ANK2, TRIM2, DPYSL3, HARS, WWC1, TIAM2, TUBB2A, AKAP9, CLU, DPYSL2, NEFM, AGTPBP1, CNKSR2, NCOR2, DYNC1H1, PPP1R13B, SNX6, GSE1, ACTG1, PAFAH1B1, PPM1E, SMARCE1, NCK2, LTBR, CEP63, TMEM17, XPO1, SMURF1, EGFR, KBTBD7, IL20RA, MRPS11, UBE2A, TRAF6, MAP3K7, TAB2, IKBKBDGCR8NCL, HSPA5, HSPA8, HNRNPR, DDX5, DDX17, FUS, HNRNPH1, DHX9, HNRNPU, ILF3, DROSHA, CUL3, APP, PRPF4, MAPRE2, NAT10, PLEK2, RPRD2, FLII, CDT1, SRPK1, SRPK2, CDKN2A, ERH, MAPK1, PRMT1, PYCRL, RAE1, MEOX2, BMI1, EWSR1, HNRNPUL1, KIF11, SYN1, CTR9, TFG, ZWINT, KLF8, FANCI, FAM46A, SMC6, KIF15, TLN2, RRP8, ZNF7, PABPC4L, CENPI, ITGB3BP, CENPO, SHQ1, CENPC, CENPN, CENPU, ZNF189, PAPD5, ZNF70, CENPQ, ZNF483, ZNF800, NSA2, WHSC1, GNL2, UPF1, BEND7, NMNAT1, RPL26L1, DKC1, TTF1, DDX31, KNOP1, BRIX1, RALY, GTPBP4, MPHOSPH10, ZNF324B, DDX24, CCDC137, ZNF689, NOP2, GLYR1, ZFP62, DDX27, REXO4, DDX10, MECP2, UTP23, ZCCHC7, RPF2, ZBTB48, FTSJ3, LARP1, ZNF22, RPL17, MAK16, STAU2, LARP1B, RBM28, DNTTIP2, ZNF771, NVL, ZC3HAV1, MOV10, DDX18, KIAA0020, SURF6, FCF1, PINX1, SPTY2D1, ZNF646, PAK1IP1, RPLP2, CENPH, ZNF777, CTCF, DHX30, NOL10, RPS13, REPIN1, PRKRA, RPL7A, HIST2H2AB, RPL10A, WDR12, ZNF668, DDX56, NIFK, DDX54, POP1, RPS8, HERC5, NOC3L, NR2E1, KHSRP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNIK_DGCR8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNIK_DGCR8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNIKC0036341Schizophrenia1PSYGENET
HgeneTNIKC0037274Dermatologic disorders1CTD_human
HgeneTNIKC0311375Arsenic Poisoning1CTD_human
HgeneTNIKC3495559Juvenile arthritis1CTD_human
TgeneDGCR8C0036341Schizophrenia3PSYGENET
TgeneDGCR8C0004936Mental disorders1CTD_human
TgeneDGCR8C0011570Mental Depression1PSYGENET
TgeneDGCR8C0011581Depressive disorder1PSYGENET
TgeneDGCR8C0033975Psychotic Disorders1PSYGENET
TgeneDGCR8C0349204Nonorganic psychosis1PSYGENET