FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38873

FusionGeneSummary for TNFSF10_SREBF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFSF10_SREBF2
Fusion gene ID: 38873
HgeneTgene
Gene symbol

TNFSF10

SREBF2

Gene ID

8743

6721

Gene nameTNF superfamily member 10sterol regulatory element binding transcription factor 2
SynonymsAPO2L|Apo-2L|CD253|TL2|TNLG6A|TRAILSREBP-2|SREBP2|bHLHd2
Cytomap

3q26.31

22q13.2

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superfsterol regulatory element-binding protein 2class D basic helix-loop-helix protein 2
Modification date2018052220180522
UniProtAcc

P50591

Q12772

Ensembl transtripts involved in fusion geneENST00000241261, ENST00000420541, 
ENST00000361204, ENST00000491541, 
Fusion gene scores* DoF score6 X 5 X 3=9012 X 12 X 5=720
# samples 614
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNFSF10 [Title/Abstract] AND SREBF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNFSF10

GO:0043065

positive regulation of apoptotic process

21525171

HgeneTNFSF10

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

21459798|21525171|22266862

HgeneTNFSF10

GO:0090200

positive regulation of release of cytochrome c from mitochondria

22266862

HgeneTNFSF10

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

20097879|21525171|22266862

TgeneSREBF2

GO:0000122

negative regulation of transcription by RNA polymerase II

15358760|19098903

TgeneSREBF2

GO:0010886

positive regulation of cholesterol storage

15358760

TgeneSREBF2

GO:0045944

positive regulation of transcription by RNA polymerase II

12242332|12446768

TgeneSREBF2

GO:0072368

regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter

15358760

TgeneSREBF2

GO:0090370

negative regulation of cholesterol efflux

15358760


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA951173TNFSF10chr3

172232702

-SREBF2chr22

42318720

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000241261ENST00000361204TNFSF10chr3

172232702

-SREBF2chr22

42318720

+
intron-intronENST00000241261ENST00000491541TNFSF10chr3

172232702

-SREBF2chr22

42318720

+
intron-intronENST00000420541ENST00000361204TNFSF10chr3

172232702

-SREBF2chr22

42318720

+
intron-intronENST00000420541ENST00000491541TNFSF10chr3

172232702

-SREBF2chr22

42318720

+

Top

FusionProtFeatures for TNFSF10_SREBF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNFSF10

P50591

SREBF2

Q12772

Cytokine that binds to TNFRSF10A/TRAILR1,TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andpossibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).Induces apoptosis. Its activity may be modulated by binding to thedecoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andTNFRSF11B/OPG that cannot induce apoptosis.{ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. Transcriptional activator required for lipidhomeostasis. Regulates transcription of the LDL receptor gene aswell as the cholesterol and to a lesser degree the fatty acidsynthesis pathway (By similarity). Binds the sterol regulatoryelement 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking regionof the LDRL and HMG-CoA synthase genes. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TNFSF10_SREBF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TNFSF10_SREBF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TNFSF10_SREBF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TNFSF10_SREBF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNFSF10C0033578Prostatic Neoplasms4CTD_human
HgeneTNFSF10C0017638Glioma2CTD_human
HgeneTNFSF10C0027659Neoplasms, Experimental2CTD_human
HgeneTNFSF10C0027686Pathologic Neovascularization2CTD_human
HgeneTNFSF10C0000786Spontaneous abortion1CTD_human
HgeneTNFSF10C0007134Renal Cell Carcinoma1CTD_human
HgeneTNFSF10C0009375Colonic Neoplasms1CTD_human
HgeneTNFSF10C0009404Colorectal Neoplasms1CTD_human
HgeneTNFSF10C0014170Endometrial Neoplasms1CTD_human
HgeneTNFSF10C0017636Glioblastoma1CTD_human
HgeneTNFSF10C0021400Influenza1CTD_human
HgeneTNFSF10C0022665Kidney Neoplasm1CTD_human
HgeneTNFSF10C0023418leukemia1CTD_human
HgeneTNFSF10C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneTNFSF10C0023903Liver neoplasms1CTD_human
HgeneTNFSF10C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneTNFSF10C0027627Neoplasm Metastasis1CTD_human
HgeneTNFSF10C0027819Neuroblastoma1CTD_human
HgeneTNFSF10C0030297Pancreatic Neoplasm1CTD_human
HgeneTNFSF10C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneTNFSF10C0919267ovarian neoplasm1CTD_human
HgeneTNFSF10C1458155Mammary Neoplasms1CTD_human
HgeneTNFSF10C2239176Liver carcinoma1CTD_human
TgeneSREBF2C0021655Insulin Resistance1CTD_human
TgeneSREBF2C0022661Kidney Failure, Chronic1CTD_human
TgeneSREBF2C0036341Schizophrenia1PSYGENET
TgeneSREBF2C0038356Stomach Neoplasms1CTD_human
TgeneSREBF2C2239176Liver carcinoma1CTD_human