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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38853

FusionGeneSummary for TNFRSF10B_LOXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFRSF10B_LOXL2
Fusion gene ID: 38853
HgeneTgene
Gene symbol

TNFRSF10B

LOXL2

Gene ID

8795

4017

Gene nameTNF receptor superfamily member 10blysyl oxidase like 2
SynonymsCD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9LOR|LOR2|WS9-14
Cytomap

8p21.3

8p21.3

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor receptor superfamily member 10BFas-like proteinTNF-related apoptosis-inducing ligand receptor 2apoptosis inducing protein TRICK2A/2Bapoptosis inducing receptor TRAIL-R2cytotoxic TRAIL receptor-2death domain containing receptor lysyl oxidase homolog 2lysyl oxidase related 2lysyl oxidase-like 2 delta e13lysyl oxidase-like 2 proteinlysyl oxidase-like protein 2lysyl oxidase-related protein 2lysyl oxidase-related protein WS9-14
Modification date2018052720180523
UniProtAcc

O14763

Q9Y4K0

Ensembl transtripts involved in fusion geneENST00000276431, ENST00000347739, 
ENST00000542226, ENST00000519910, 
ENST00000389131, ENST00000518472, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 4=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNFRSF10B [Title/Abstract] AND LOXL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNFRSF10B

GO:0034976

response to endoplasmic reticulum stress

15322075

TgeneLOXL2

GO:0000122

negative regulation of transcription by RNA polymerase II

25959397

TgeneLOXL2

GO:0001837

epithelial to mesenchymal transition

16096638

TgeneLOXL2

GO:0006464

cellular protein modification process

23319596

TgeneLOXL2

GO:0018057

peptidyl-lysine oxidation

25959397|27735137

TgeneLOXL2

GO:0045892

negative regulation of transcription, DNA-templated

16096638

TgeneLOXL2

GO:0046688

response to copper ion

23319596


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-7056-01ATNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000276431ENST00000389131TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
5CDS-intronENST00000276431ENST00000518472TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
5CDS-5UTRENST00000347739ENST00000389131TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
5CDS-intronENST00000347739ENST00000518472TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
5UTR-5UTRENST00000542226ENST00000389131TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
5UTR-intronENST00000542226ENST00000518472TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
intron-5UTRENST00000519910ENST00000389131TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-
intron-intronENST00000519910ENST00000518472TNFRSF10Bchr8

22926264

-LOXL2chr8

23225947

-

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FusionProtFeatures for TNFRSF10B_LOXL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNFRSF10B

O14763

LOXL2

Q9Y4K0

Receptor for the cytotoxic ligand TNFSF10/TRAIL(PubMed:10549288). The adapter molecule FADD recruits caspase-8 tothe activated receptor. The resulting death-inducing signalingcomplex (DISC) performs caspase-8 proteolytic activation whichinitiates the subsequent cascade of caspases (aspartate-specificcysteine proteases) mediating apoptosis. Promotes the activationof NF-kappa-B. Essential for ER stress-induced apoptosis.{ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288,ECO:0000269|PubMed:15322075}. Mediates the post-translational oxidative deamination oflysine residues on target proteins leading to the formation ofdeaminated lysine (allysine) (PubMed:27735137). Acts as atranscription corepressor and specifically mediates deamination oftrimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag forepigenetic transcriptional activation (PubMed:27735137). Shows noactivity against histone H3 when it is trimethylated on 'Lys-9'(H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated(H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Alsomediates deamination of methylated TAF10, a member of thetranscription factor IID (TFIID) complex, which induces release ofTAF10 from promoters, leading to inhibition of TFIID-dependenttranscription (PubMed:25959397). LOXL2-mediated deamination ofTAF10 results in transcriptional repression of genes required forembryonic stem cell pluripotency including POU5F1/OCT4, NANOG,KLF4 and SOX2 (By similarity). Involved in epithelial tomesenchymal transition (EMT) via interaction with SNAI1 andparticipates in repression of E-cadherin CDH1, probably bymediating deamination of histone H3 (PubMed:16096638,PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1in negatively regulating pericentromeric heterochromatintranscription (PubMed:24239292). SNAI1 recruits LOXL2 topericentromeric regions to oxidize histone H3 and represstranscription which leads to release of heterochromatin componentCBX5/HP1A, enabling chromatin reorganization and acquisition ofmesenchymal traits (PubMed:24239292). Interacts with theendoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1pathway of the unfolded protein response, leading to expression ofseveral transcription factors involved in EMT and subsequent EMTinduction (PubMed:28332555). Involved in E-cadherin repressionfollowing hypoxia, a hallmark of EMT believed to amplify tumoraggressiveness, suggesting that it may play a role in tumorprogression (PubMed:20026874). When secreted into theextracellular matrix, promotes cross-linking of extracellularmatrix proteins by mediating oxidative deamination of peptidyllysine residues in precursors to fibrous collagen and elastin(PubMed:20306300). Acts as a regulator of sprouting angiogenesis,probably via collagen IV scaffolding (PubMed:21835952). Acts as aregulator of chondrocyte differentiation, probably by regulatingexpression of factors that control chondrocyte differentiation (Bysimilarity). {ECO:0000250|UniProtKB:P58022,ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20026874,ECO:0000269|PubMed:20306300, ECO:0000269|PubMed:21835952,ECO:0000269|PubMed:24239292, ECO:0000269|PubMed:24414204,ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:27735137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNFRSF10B_LOXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNFRSF10B_LOXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TNFRSF10BBID, EZR, FADD, FAS, FASLG, MAPK8, MSN, CASP10, CASP8, RHOA, ARHGDIA, TNFRSF1A, TIMM50, TNFSF10, CFLAR, TRADD, RIPK1, CBL, ITCH, TNFRSF10A, TNFAIP3, TRAF2, CUL3, EGFR, TSPAN3, TMEM231, GINM1, MICA, LTBR, LSR, NDFIP1, FLVCR1, MFAP3, TMEM214, SLC15A4, PTRH2, SCAMP1, REEP5, CKAP4, STX12, LAPTM4B, RNF149, FGFR1, PRAF2, UGCG, STX3, IFNGR1, VAMP3, HEPACAM2, TMEM17, ASIC1, DDR1, LRRIQ1, SLC20A1, ARRDC3, TMEM223, TNFRSF13B, RNF11, IL1R1, FYN, SLC1A1, TRIM25, CBLBLOXL2PDIA3, MTA1, MTA2, RBBP4, RBBP7, SIN3A, HDAC1, EZH2, HIST1H3A, KLK11, TAZ, KLK5, IDS, PLAUR, TMEM25, IL12RB1, TINAGL1, LYZL2, RBM14-RBM4, OS9, DEFA1, WNT7A, PSG8, ADAMTS4, SCGB2A2, INSL5, LRP1, IK, DEFA5, FBXO7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNFRSF10B_LOXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNFRSF10B_LOXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNFRSF10BC0023904Liver Neoplasms, Experimental1CTD_human
HgeneTNFRSF10BC0030297Pancreatic Neoplasm1CTD_human
TgeneLOXL2C1458155Mammary Neoplasms2CTD_human
TgeneLOXL2C0007621Neoplastic Cell Transformation1CTD_human
TgeneLOXL2C0019163Hepatitis B1CTD_human
TgeneLOXL2C0019196Hepatitis C1CTD_human
TgeneLOXL2C0019202Hepatolenticular Degeneration1CTD_human
TgeneLOXL2C0023892Biliary cirrhosis1CTD_human
TgeneLOXL2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLOXL2C0027626Neoplasm Invasiveness1CTD_human
TgeneLOXL2C0279626Squamous cell carcinoma of esophagus1CTD_human