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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38836

FusionGeneSummary for TNC_TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNC_TPM1
Fusion gene ID: 38836
HgeneTgene
Gene symbol

TNC

TPM1

Gene ID

7134

7168

Gene nametroponin C1, slow skeletal and cardiac typetropomyosin 1
SynonymsCMD1Z|CMH13|TN-C|TNC|TNNCC15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

3p21.1

15q22.2

Type of geneprotein-codingprotein-coding
Descriptiontroponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)tropomyosin alpha-1 chainalpha-tropomyosincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappatropomyosin 1 (alpha)
Modification date2018052320180523
UniProtAcc

P24821

P09493

Ensembl transtripts involved in fusion geneENST00000535648, ENST00000346706, 
ENST00000340094, ENST00000345230, 
ENST00000350763, ENST00000341037, 
ENST00000423613, ENST00000537320, 
ENST00000542877, ENST00000481475, 
ENST00000288398, ENST00000358278, 
ENST00000560445, ENST00000403994, 
ENST00000357980, ENST00000559556, 
ENST00000559397, ENST00000267996, 
ENST00000334895, ENST00000404484, 
ENST00000560959, ENST00000559281, 
ENST00000317516, 
Fusion gene scores* DoF score5 X 6 X 3=906 X 6 X 4=144
# samples 77
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNC [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNC

GO:0006937

regulation of muscle contraction

18092822

HgeneTNC

GO:0060048

cardiac muscle contraction

25771144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1Z24727TNCchr9

117810513

+TPM1chr15

63336262

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000535648ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000535648ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000535648ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000535648ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000535648ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000535648ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000535648ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000346706ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000346706ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000340094ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000340094ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000345230ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000345230ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000350763ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000350763ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000341037ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000341037ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000423613ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000423613ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000537320ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000537320ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000542877ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000542877ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000288398TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000358278TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000560445TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000403994TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000357980TNCchr9

117810513

+TPM1chr15

63336262

+
intron-3CDSENST00000481475ENST00000559556TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000559397TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000267996TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000334895TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000404484TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000560959TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000559281TNCchr9

117810513

+TPM1chr15

63336262

+
intron-intronENST00000481475ENST00000317516TNCchr9

117810513

+TPM1chr15

63336262

+

Top

FusionProtFeatures for TNC_TPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNC

P24821

TPM1

P09493

Extracellular matrix protein implicated in guidance ofmigrating neurons as well as axons during development, synapticplasticity as well as neuronal regeneration. Promotes neuriteoutgrowth from cortical neurons grown on a monolayer ofastrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1,alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulatesangiogenesis by elongation, migration and sprouting of endothelialcells (PubMed:19884327). {ECO:0000269|PubMed:19884327}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TNC_TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TNC_TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TNC_TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPM1P09493DB11638ArtenimolTropomyosin alpha-1 chainsmall moleculeapproved|investigational

Top

RelatedDiseases for TNC_TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNCC0004096Asthma1CTD_human
HgeneTNCC0014175Endometriosis1CTD_human
HgeneTNCC0025202melanoma1CTD_human
HgeneTNCC0032226Pleural Diseases1CTD_human
HgeneTNCC0042345Varicosity1CTD_human
HgeneTNCC0273115Lung Injury1CTD_human
HgeneTNCC3810170DEAFNESS, AUTOSOMAL DOMINANT 561UNIPROT
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)5CTD_human;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y2CTD_human;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human