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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38833

FusionGeneSummary for TNC_COG6

check button Fusion gene summary
Fusion gene informationFusion gene name: TNC_COG6
Fusion gene ID: 38833
HgeneTgene
Gene symbol

TNC

COG6

Gene ID

7134

57511

Gene nametroponin C1, slow skeletal and cardiac typecomponent of oligomeric golgi complex 6
SynonymsCMD1Z|CMH13|TN-C|TNC|TNNCCDG2L|COD2|SHNS
Cytomap

3p21.1

13q14.11

Type of geneprotein-codingprotein-coding
Descriptiontroponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)conserved oligomeric Golgi complex subunit 6COG complex subunit 6complexed with Dor1p 2conserved oligomeric Golgi complex protein 6testicular tissue protein Li 41
Modification date2018052320180523
UniProtAcc

P24821

Q9Y2V7

Ensembl transtripts involved in fusion geneENST00000535648, ENST00000346706, 
ENST00000340094, ENST00000345230, 
ENST00000350763, ENST00000341037, 
ENST00000423613, ENST00000537320, 
ENST00000542877, ENST00000481475, 
ENST00000416691, ENST00000455146, 
ENST00000465775, 
Fusion gene scores* DoF score5 X 6 X 3=901 X 1 X 1=1
# samples 71
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TNC [Title/Abstract] AND COG6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNC

GO:0006937

regulation of muscle contraction

18092822

HgeneTNC

GO:0060048

cardiac muscle contraction

25771144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG459123TNCchr9

117833116

-COG6chr13

40330485

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000535648ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000535648ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000535648ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000346706ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000346706ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000346706ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000340094ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000340094ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000340094ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000345230ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000345230ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000345230ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000350763ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000350763ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000350763ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000341037ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000341037ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000341037ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000423613ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000423613ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000423613ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000537320ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000537320ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000537320ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000542877ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000542877ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000542877ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000481475ENST00000416691TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000481475ENST00000455146TNCchr9

117833116

-COG6chr13

40330485

+
intron-intronENST00000481475ENST00000465775TNCchr9

117833116

-COG6chr13

40330485

+

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FusionProtFeatures for TNC_COG6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNC

P24821

COG6

Q9Y2V7

Extracellular matrix protein implicated in guidance ofmigrating neurons as well as axons during development, synapticplasticity as well as neuronal regeneration. Promotes neuriteoutgrowth from cortical neurons grown on a monolayer ofastrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1,alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulatesangiogenesis by elongation, migration and sprouting of endothelialcells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. Required for normal Golgi function. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TNC_COG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TNC_COG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TNC_COG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TNC_COG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNCC0004096Asthma1CTD_human
HgeneTNCC0014175Endometriosis1CTD_human
HgeneTNCC0025202melanoma1CTD_human
HgeneTNCC0032226Pleural Diseases1CTD_human
HgeneTNCC0042345Varicosity1CTD_human
HgeneTNCC0273115Lung Injury1CTD_human
HgeneTNCC3810170DEAFNESS, AUTOSOMAL DOMINANT 561UNIPROT
TgeneCOG6C3553230CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl1ORPHANET;UNIPROT